Molecular dissection of ALS‐linked TDP‐43 – involvement of the Gly‐rich domain in interaction with G‐quadruplex mRNA

TDP‐43 is the major pathogenic protein of amyotrophic lateral sclerosis (ALS). Previously, we identified that TDP‐43 interacts with G‐quadruplex (G4)‐containing RNA and is involved in their long‐distance transport in neurons. For the molecular dissection of the TDP‐43 and G4‐RNA interaction, we anal...

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