The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion

The neuronal damage and accompanied functional deficits induced by cerebral ischemia are among the most common causes of disabilities in adults. Activation of subtypes of peroxisome proliferator-activated receptors (PPARs); PPAR-α and PPAR-γ have shown neuroprotective effects in different neurodegen...

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Veröffentlicht in:	Life sciences (1973) 2020-07, Vol.252, p.117679-10, Article 117679
Hauptverfasser:	Shehata, Alaa H.F., Ahmed, Al-Shaimaa F., Abdelrehim, Amany B., Heeba, Gehan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Apoptosis Behavioral deficits Carotid artery Cerebral blood flow Cerebral cortex Cerebral infarction Cerebral ischemia reperfusion Cortex (somatosensory) Disabilities Fenofibrate Inflammation Ischemia Ladder test Markers Neurodegenerative diseases Neuroprotection Occlusion Open field test Oxidative stress Peroxisome proliferator-activated receptors Pioglitazone Pretreatment Reperfusion Rodents Tape removal test
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