Brain bases of recovery following cognitive rehabilitation for traumatic brain injury: a preliminary study
Many patients with traumatic brain injury (TBI) have persistent cognitive deficits, including decreased attention and working memory. This preliminary study examined fMRI data from a clinical trial implementing a 4-week virtual reality driving intervention to assess how sustained training can improv...
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| Veröffentlicht in: | Brain imaging and behavior 2021-02, Vol.15 (1), p.410-420 |
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| creator | Gimbel, Sarah I. Ettenhofer, Mark L. Cordero, Evelyn Roy, Michael Chan, Leighton |
| description | Many patients with traumatic brain injury (TBI) have persistent cognitive deficits, including decreased attention and working memory. This preliminary study examined fMRI data from a clinical trial implementing a 4-week virtual reality driving intervention to assess how sustained training can improve deficits related to traumatic brain injury. Previously-reported behavioral findings showed improvements in working memory and processing speed in those who received the intervention; this report explores the brain bases of these effects by comparing neural activity related to working memory (n-back task) and resting state connectivity before and after the intervention. In the baseline visit (n = 24), working memory activity was prominent in bilateral DLPFC and prefrontal cortex, anterior insula, medial superior frontal gyrus, left thalamus, bilateral supramarginal / angular gyrus, precuneus, and left posterior middle temporal gyrus. Following intervention, participants showed less global activation on the n-back task, with regions of activity only in the bilateral middle frontal cortex, posterior middle frontal gyrus, and supramarginal gyrus. Activity related to working memory load was reduced for the group that went through the intervention (n = 7) compared to the waitlist control group (n = 4). These results suggest that successful cognitive rehabilitation of working memory in TBI may be associated with increased efficiency of brain networks, evidenced by reduced activation of brain activity during cognitive processing. These results highlight the importance of examining brain activity related to cognitive rehabilitation of attention and working memory after brain injury. |
| doi_str_mv | 10.1007/s11682-020-00269-8 |
| format | Article |
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This preliminary study examined fMRI data from a clinical trial implementing a 4-week virtual reality driving intervention to assess how sustained training can improve deficits related to traumatic brain injury. Previously-reported behavioral findings showed improvements in working memory and processing speed in those who received the intervention; this report explores the brain bases of these effects by comparing neural activity related to working memory (n-back task) and resting state connectivity before and after the intervention. In the baseline visit (n = 24), working memory activity was prominent in bilateral DLPFC and prefrontal cortex, anterior insula, medial superior frontal gyrus, left thalamus, bilateral supramarginal / angular gyrus, precuneus, and left posterior middle temporal gyrus. Following intervention, participants showed less global activation on the n-back task, with regions of activity only in the bilateral middle frontal cortex, posterior middle frontal gyrus, and supramarginal gyrus. Activity related to working memory load was reduced for the group that went through the intervention (n = 7) compared to the waitlist control group (n = 4). These results suggest that successful cognitive rehabilitation of working memory in TBI may be associated with increased efficiency of brain networks, evidenced by reduced activation of brain activity during cognitive processing. 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This preliminary study examined fMRI data from a clinical trial implementing a 4-week virtual reality driving intervention to assess how sustained training can improve deficits related to traumatic brain injury. Previously-reported behavioral findings showed improvements in working memory and processing speed in those who received the intervention; this report explores the brain bases of these effects by comparing neural activity related to working memory (n-back task) and resting state connectivity before and after the intervention. In the baseline visit (n = 24), working memory activity was prominent in bilateral DLPFC and prefrontal cortex, anterior insula, medial superior frontal gyrus, left thalamus, bilateral supramarginal / angular gyrus, precuneus, and left posterior middle temporal gyrus. Following intervention, participants showed less global activation on the n-back task, with regions of activity only in the bilateral middle frontal cortex, posterior middle frontal gyrus, and supramarginal gyrus. Activity related to working memory load was reduced for the group that went through the intervention (n = 7) compared to the waitlist control group (n = 4). These results suggest that successful cognitive rehabilitation of working memory in TBI may be associated with increased efficiency of brain networks, evidenced by reduced activation of brain activity during cognitive processing. 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diagnostic imaging</topic><topic>Brain Injuries, Traumatic - diagnostic imaging</topic><topic>Brain mapping</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Computer applications</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Cortex (temporal)</topic><topic>Frontal gyrus</topic><topic>Functional magnetic resonance imaging</topic><topic>Head injuries</topic><topic>Humans</topic><topic>Information processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Memory</topic><topic>Memory, Short-Term</topic><topic>Mental task performance</topic><topic>Neural networks</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Prefrontal cortex</topic><topic>Psychiatry</topic><topic>Recovery (Medical)</topic><topic>Rehabilitation</topic><topic>Short term memory</topic><topic>Temporal gyrus</topic><topic>Thalamus</topic><topic>Traumatic brain injury</topic><topic>Virtual reality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gimbel, Sarah I.</creatorcontrib><creatorcontrib>Ettenhofer, Mark L.</creatorcontrib><creatorcontrib>Cordero, Evelyn</creatorcontrib><creatorcontrib>Roy, Michael</creatorcontrib><creatorcontrib>Chan, Leighton</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gimbel, Sarah I.</au><au>Ettenhofer, Mark L.</au><au>Cordero, Evelyn</au><au>Roy, Michael</au><au>Chan, Leighton</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain bases of recovery following cognitive rehabilitation for traumatic brain injury: a preliminary study</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>15</volume><issue>1</issue><spage>410</spage><epage>420</epage><pages>410-420</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>Many patients with traumatic brain injury (TBI) have persistent cognitive deficits, including decreased attention and working memory. This preliminary study examined fMRI data from a clinical trial implementing a 4-week virtual reality driving intervention to assess how sustained training can improve deficits related to traumatic brain injury. Previously-reported behavioral findings showed improvements in working memory and processing speed in those who received the intervention; this report explores the brain bases of these effects by comparing neural activity related to working memory (n-back task) and resting state connectivity before and after the intervention. In the baseline visit (n = 24), working memory activity was prominent in bilateral DLPFC and prefrontal cortex, anterior insula, medial superior frontal gyrus, left thalamus, bilateral supramarginal / angular gyrus, precuneus, and left posterior middle temporal gyrus. Following intervention, participants showed less global activation on the n-back task, with regions of activity only in the bilateral middle frontal cortex, posterior middle frontal gyrus, and supramarginal gyrus. Activity related to working memory load was reduced for the group that went through the intervention (n = 7) compared to the waitlist control group (n = 4). These results suggest that successful cognitive rehabilitation of working memory in TBI may be associated with increased efficiency of brain networks, evidenced by reduced activation of brain activity during cognitive processing. These results highlight the importance of examining brain activity related to cognitive rehabilitation of attention and working memory after brain injury.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32328915</pmid><doi>10.1007/s11682-020-00269-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9381-7578</orcidid><orcidid>https://orcid.org/0000-0002-1636-9641</orcidid></addata></record> |
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| subjects | Attention Biomedical and Life Sciences Biomedicine Brain Brain - diagnostic imaging Brain Injuries, Traumatic - diagnostic imaging Brain mapping Cognition Cognitive ability Computer applications Cortex (frontal) Cortex (parietal) Cortex (temporal) Frontal gyrus Functional magnetic resonance imaging Head injuries Humans Information processing Magnetic Resonance Imaging Memory Memory, Short-Term Mental task performance Neural networks Neuropsychology Neuroradiology Neurosciences Original Research Prefrontal cortex Psychiatry Recovery (Medical) Rehabilitation Short term memory Temporal gyrus Thalamus Traumatic brain injury Virtual reality |
| title | Brain bases of recovery following cognitive rehabilitation for traumatic brain injury: a preliminary study |
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