Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery
Objective The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PN...
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| Veröffentlicht in: | General thoracic and cardiovascular surgery 2020-10, Vol.68 (10), p.1163-1171 |
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| creator | Hayasaka, Kazuki Shiono, Satoshi Suzuki, Katsuyuki Endoh, Makoto Okada, Yoshinori |
| description | Objective
The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor.
Methods
Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. Pre-PNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis.
Results
We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (
P
|
| doi_str_mv | 10.1007/s11748-020-01366-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2394885886</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2394885886</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-438d2c6d5e972807f620fe50f3f14af3e3c3e336c9096af8b2417eb18905bad53</originalsourceid><addsrcrecordid>eNp9kctOAyEUhonR2Fp9AReGxI2bUS4zXJam8ZaY6ELXhDLQTDOFCjPGvr3UqdW4cAGccL7zczg_AKcYXWKE-FXCmJeiQAQVCFPGCr4HxlgwWjCO6f4uRtUIHKW0QKhiAleHYEQJJUJKOgaL55C6sLJRd827hasY5j7fNAb6votN1wSvW9j42n5AnaD-TThtuhChdp2N0AdfpKVuW2hs3trez6HR3uRU6uPcxvUxOHC6TfZke07A6-3Ny_S-eHy6e5hePxaGStkVJRU1MayurOREIO4YQc5WyFGHS-2opSYvyoxEkmknZqTE3M6wkKia6bqiE3Ax6OZW33qbOrVs0qYp7W3okyJUlkJUIg9nAs7_oIvQx_zjTEkseIkRkZkiA2ViSClap1axWeq4VhipjRNqcEJlJ9SXE4rnorOtdD9b2npX8j36DNABSDnl84B-3v5H9hMJJ5T4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918741029</pqid></control><display><type>article</type><title>Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>ProQuest Central</source><creator>Hayasaka, Kazuki ; Shiono, Satoshi ; Suzuki, Katsuyuki ; Endoh, Makoto ; Okada, Yoshinori</creator><creatorcontrib>Hayasaka, Kazuki ; Shiono, Satoshi ; Suzuki, Katsuyuki ; Endoh, Makoto ; Okada, Yoshinori</creatorcontrib><description>Objective
The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor.
Methods
Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. Pre-PNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis.
Results
We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (
P
< 0.001), 92.0%/74.8% (
P
= 0.001), and 80.5%/55.3% (
P
< 0.001). respectively. Multivariate analysis showed that the post-PNI was a significant prognostic factor (
P
< 0.001). We further revealed the equivalent OS with “low pre-PNI and high post-PNI” patients or “high pre-PNI and high post-PNI” patients.
Conclusions
Post-PNI status was a significant prognostic factor and perioperative PNI changes could play a significant role in the survival of patients with NSCLC after surgery.</description><identifier>ISSN: 1863-6705</identifier><identifier>EISSN: 1863-6713</identifier><identifier>DOI: 10.1007/s11748-020-01366-7</identifier><identifier>PMID: 32328993</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Aged ; Body mass index ; Cancer surgery ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - surgery ; Cardiac Surgery ; Cardiology ; Chemotherapy ; Female ; Follow-Up Studies ; Humans ; Lung cancer ; Lung Neoplasms - mortality ; Lung Neoplasms - surgery ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Nutrition Assessment ; Nutritional Status ; Original Article ; Ostomy ; Outpatient care facilities ; Patients ; Postoperative Complications ; Postoperative Period ; Prognosis ; ROC Curve ; Surgical Oncology ; Surveillance ; Survival Analysis ; Thoracic Surgery</subject><ispartof>General thoracic and cardiovascular surgery, 2020-10, Vol.68 (10), p.1163-1171</ispartof><rights>The Japanese Association for Thoracic Surgery 2020</rights><rights>The Japanese Association for Thoracic Surgery 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-438d2c6d5e972807f620fe50f3f14af3e3c3e336c9096af8b2417eb18905bad53</citedby><cites>FETCH-LOGICAL-c399t-438d2c6d5e972807f620fe50f3f14af3e3c3e336c9096af8b2417eb18905bad53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11748-020-01366-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918741029?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,33722,41464,42533,43781,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32328993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayasaka, Kazuki</creatorcontrib><creatorcontrib>Shiono, Satoshi</creatorcontrib><creatorcontrib>Suzuki, Katsuyuki</creatorcontrib><creatorcontrib>Endoh, Makoto</creatorcontrib><creatorcontrib>Okada, Yoshinori</creatorcontrib><title>Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery</title><title>General thoracic and cardiovascular surgery</title><addtitle>Gen Thorac Cardiovasc Surg</addtitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><description>Objective
The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor.
Methods
Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. Pre-PNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis.
Results
We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (
P
< 0.001), 92.0%/74.8% (
P
= 0.001), and 80.5%/55.3% (
P
< 0.001). respectively. Multivariate analysis showed that the post-PNI was a significant prognostic factor (
P
< 0.001). We further revealed the equivalent OS with “low pre-PNI and high post-PNI” patients or “high pre-PNI and high post-PNI” patients.
Conclusions
Post-PNI status was a significant prognostic factor and perioperative PNI changes could play a significant role in the survival of patients with NSCLC after surgery.</description><subject>Aged</subject><subject>Body mass index</subject><subject>Cancer surgery</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - surgery</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Original Article</subject><subject>Ostomy</subject><subject>Outpatient care facilities</subject><subject>Patients</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>ROC Curve</subject><subject>Surgical Oncology</subject><subject>Surveillance</subject><subject>Survival Analysis</subject><subject>Thoracic Surgery</subject><issn>1863-6705</issn><issn>1863-6713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctOAyEUhonR2Fp9AReGxI2bUS4zXJam8ZaY6ELXhDLQTDOFCjPGvr3UqdW4cAGccL7zczg_AKcYXWKE-FXCmJeiQAQVCFPGCr4HxlgwWjCO6f4uRtUIHKW0QKhiAleHYEQJJUJKOgaL55C6sLJRd827hasY5j7fNAb6votN1wSvW9j42n5AnaD-TThtuhChdp2N0AdfpKVuW2hs3trez6HR3uRU6uPcxvUxOHC6TfZke07A6-3Ny_S-eHy6e5hePxaGStkVJRU1MayurOREIO4YQc5WyFGHS-2opSYvyoxEkmknZqTE3M6wkKia6bqiE3Ax6OZW33qbOrVs0qYp7W3okyJUlkJUIg9nAs7_oIvQx_zjTEkseIkRkZkiA2ViSClap1axWeq4VhipjRNqcEJlJ9SXE4rnorOtdD9b2npX8j36DNABSDnl84B-3v5H9hMJJ5T4</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Hayasaka, Kazuki</creator><creator>Shiono, Satoshi</creator><creator>Suzuki, Katsuyuki</creator><creator>Endoh, Makoto</creator><creator>Okada, Yoshinori</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery</title><author>Hayasaka, Kazuki ; Shiono, Satoshi ; Suzuki, Katsuyuki ; Endoh, Makoto ; Okada, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-438d2c6d5e972807f620fe50f3f14af3e3c3e336c9096af8b2417eb18905bad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Body mass index</topic><topic>Cancer surgery</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - surgery</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Original Article</topic><topic>Ostomy</topic><topic>Outpatient care facilities</topic><topic>Patients</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>ROC Curve</topic><topic>Surgical Oncology</topic><topic>Surveillance</topic><topic>Survival Analysis</topic><topic>Thoracic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayasaka, Kazuki</creatorcontrib><creatorcontrib>Shiono, Satoshi</creatorcontrib><creatorcontrib>Suzuki, Katsuyuki</creatorcontrib><creatorcontrib>Endoh, Makoto</creatorcontrib><creatorcontrib>Okada, Yoshinori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>General thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayasaka, Kazuki</au><au>Shiono, Satoshi</au><au>Suzuki, Katsuyuki</au><au>Endoh, Makoto</au><au>Okada, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery</atitle><jtitle>General thoracic and cardiovascular surgery</jtitle><stitle>Gen Thorac Cardiovasc Surg</stitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>68</volume><issue>10</issue><spage>1163</spage><epage>1171</epage><pages>1163-1171</pages><issn>1863-6705</issn><eissn>1863-6713</eissn><abstract>Objective
The prognostic nutritional index (PNI) is an immunonutrition index. Although preoperative PNI (pre-PNI) has been reported as a prognostic factor for patients with surgically resected non-small cell lung cancer (NSCLC), it is unclear whether postoperative PNI (post-PNI) and perioperative PNI change is a prognostic factor.
Methods
Clinicopathological data from 262 consecutive patients who underwent lobectomy for NSCLC were collected. Pre-PNI and post-PNI were calculated within 1 month before surgery and at 1 month after surgery, respectively. We investigated which clinicopathological factors contributed to the post-PNI, the differences in prognosis according to the post-PNI status, and the impact of perioperative PNI change on prognosis.
Results
We set 50 and 45 as an optimal cutoff value of pre-PNI and post-PNI for OS using a receiver operating characteristic curve. Patients who were older and male and who had lower pre-PNI, larger thoracotomy size, longer operative duration, larger blood loss during surgery, and postoperative pulmonary complications showed significantly lower post-PNI. The 5-year overall survival (OS), lung cancer-specific survival, and recurrence-free survival rates for the high/low post-PNI groups were 87.4%/58.4% (
P
< 0.001), 92.0%/74.8% (
P
= 0.001), and 80.5%/55.3% (
P
< 0.001). respectively. Multivariate analysis showed that the post-PNI was a significant prognostic factor (
P
< 0.001). We further revealed the equivalent OS with “low pre-PNI and high post-PNI” patients or “high pre-PNI and high post-PNI” patients.
Conclusions
Post-PNI status was a significant prognostic factor and perioperative PNI changes could play a significant role in the survival of patients with NSCLC after surgery.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32328993</pmid><doi>10.1007/s11748-020-01366-7</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; ProQuest Central |
| subjects | Aged Body mass index Cancer surgery Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - surgery Cardiac Surgery Cardiology Chemotherapy Female Follow-Up Studies Humans Lung cancer Lung Neoplasms - mortality Lung Neoplasms - surgery Male Medical prognosis Medicine Medicine & Public Health Middle Aged Nutrition Assessment Nutritional Status Original Article Ostomy Outpatient care facilities Patients Postoperative Complications Postoperative Period Prognosis ROC Curve Surgical Oncology Surveillance Survival Analysis Thoracic Surgery |
| title | Postoperative prognostic nutritional index as a prognostic factor after non-small cell lung cancer surgery |
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