Determination of amphenicol antibiotics and their glucuronide metabolites in urine samples using liquid chromatography with quadrupole time-of-flight mass spectrometry

•Amphenicol antibiotics are determined in human urine samples.•Free antibiotics are mainly excreted from the body in the urine as glucuronide conjugates.•An enzymatic hydrolysis allowed discrimination between free and conjugated forms.•The use of LC avoids derivatization of the amphenicols.•The high...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2020-06, Vol.1146, p.122122-122122, Article 122122
Hauptverfasser:	Pastor-Belda, Marta, Campillo, Natalia, Arroyo-Manzanares, Natalia, Hernández-Córdoba, Manuel, Viñas, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphenicols Dispersive liquid-liquid microextraction Glucuronide Human urine Liquid chromatography Quadrupole time-of-flight mass spectrometry
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