Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion

Ischemia-reperfusion injury (IRI) is harmful to patients following kidney transplantation. Hypothermic machine perfusion (HMP) can be adopted to preserve grafts and reduce consequential injury. We hypothesized that aldehyde dehydrogenase 2 (ALDH2) partly mitigates kidney IRI via regulating excessive...

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Veröffentlicht in:Life sciences (1973) 2020-07, Vol.253, p.117705-9, Article 117705
Hauptverfasser: Lin, Danni, Xiang, Tao, Qiu, Qiangmin, Leung, Junto, Xu, Junjie, Zhou, Wei, Hu, Qianchao, Lan, Jianan, Liu, Zhongzhong, Zhong, Zibiao, Wang, Yanfeng, Ye, Qifa
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Sprache:eng
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