Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke
Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps toward...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2020-04, Vol.21 (8), p.2845, Article 2845 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | 2845 |
| container_title | International journal of molecular sciences |
| container_volume | 21 |
| creator | Brown, John Park, You Jeong Lee, Jea-Young Chase, Thomas N. Koga, Minako Borlongan, Cesar V. |
| description | Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells' ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials. |
| doi_str_mv | 10.3390/ijms21082845 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2394876752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_80918867d05f478781e39550efdf7fa3</doaj_id><sourcerecordid>2394876752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-4916c5f038b26d32538d901887b6fb638c62328aefe0549f29cce63411d87d093</originalsourceid><addsrcrecordid>eNqNkUtvEzEUhUcIREthxxqNxAYJBvx-bJDa4VWphEXL2nI8163DZBzsmVT99zhJiVJWrHx1_fnc43uq6iVG7ynV6ENYLDPBSBHF-KPqGDNCGoSEfHxQH1XPcl4gRCjh-ml1RDeFwvS4mp3FAervNqV423yCFNbQ1bP2skG4bqHvc33are3goLb1LK6h33abM5sLd3UDya7uah9TfTmm-AueV0-87TO8uD9Pqp9fPl-135qLH1_P29OLxjGpxoZpLBz3iKo5EV3xQlWnEVZKzoWfC6qcKA6VBQ-IM-2Jdg4EZRh3SnZI05PqfKfbRbswqxSWNt2ZaIPZNmK6NjaNwfVgFNJFWJRn3JfhUmGgmnMEvvPSW1q0Pu60VtN8CZ2DYUy2fyD68GYIN-Y6ro0kmFO2EXhzL5Di7wnyaJYhu7ImO0CcsiFUMyWF5KSgr_9BF3FKQ1nVlmKMaCoL9W5HuRRzTuD3ZjAym9DNYegFf3X4gT38N-UCvN0BtzCPPrsAJdA9hhDilHPBKSoRbKar_6fbMNoxxKGN0zDSP-oSxQI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2394442937</pqid></control><display><type>article</type><title>Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke</title><source>MEDLINE</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Brown, John ; Park, You Jeong ; Lee, Jea-Young ; Chase, Thomas N. ; Koga, Minako ; Borlongan, Cesar V.</creator><creatorcontrib>Brown, John ; Park, You Jeong ; Lee, Jea-Young ; Chase, Thomas N. ; Koga, Minako ; Borlongan, Cesar V.</creatorcontrib><description>Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells' ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21082845</identifier><identifier>PMID: 32325813</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Animals ; basic fibroblast growth factor ; Biochemistry & Molecular Biology ; Biomarkers ; Bone marrow ; Brain Ischemia - complications ; Cell Line ; Cell lines ; Cell- and Tissue-Based Therapy - methods ; Cerebral blood flow ; cerebral ischemia ; Chemistry ; Chemistry, Multidisciplinary ; Clinical trials ; Consortia ; Cytokines - metabolism ; Deprivation ; Disease Models, Animal ; FDA approval ; Fibroblast growth factor 2 ; Filopodia ; Glucose ; Growth factors ; Humans ; Inflammation ; Interleukin 6 ; Ischemia ; Kinases ; Life Sciences & Biomedicine ; Mesenchymal Stem Cell Transplantation - methods ; mesenchymal stem cells ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; Mesenchyme ; middle cerebral artery occlusion ; Mitochondria ; Neural stem cells ; Occlusion ; Physical Sciences ; Progenitor cells ; Recovery of function ; regenerative medicine ; Review ; Science & Technology ; Stem cell transplantation ; Stem cells ; Stroke ; Stroke - etiology ; Stroke - metabolism ; Stroke - therapy ; Studies ; Transplantation</subject><ispartof>International journal of molecular sciences, 2020-04, Vol.21 (8), p.2845, Article 2845</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000535565300187</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c478t-4916c5f038b26d32538d901887b6fb638c62328aefe0549f29cce63411d87d093</citedby><cites>FETCH-LOGICAL-c478t-4916c5f038b26d32538d901887b6fb638c62328aefe0549f29cce63411d87d093</cites><orcidid>0000-0002-2966-9782 ; 0000-0001-5270-3224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215343/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215343/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32325813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, John</creatorcontrib><creatorcontrib>Park, You Jeong</creatorcontrib><creatorcontrib>Lee, Jea-Young</creatorcontrib><creatorcontrib>Chase, Thomas N.</creatorcontrib><creatorcontrib>Koga, Minako</creatorcontrib><creatorcontrib>Borlongan, Cesar V.</creatorcontrib><title>Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke</title><title>International journal of molecular sciences</title><addtitle>INT J MOL SCI</addtitle><addtitle>Int J Mol Sci</addtitle><description>Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells' ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials.</description><subject>Animals</subject><subject>basic fibroblast growth factor</subject><subject>Biochemistry & Molecular Biology</subject><subject>Biomarkers</subject><subject>Bone marrow</subject><subject>Brain Ischemia - complications</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Cerebral blood flow</subject><subject>cerebral ischemia</subject><subject>Chemistry</subject><subject>Chemistry, Multidisciplinary</subject><subject>Clinical trials</subject><subject>Consortia</subject><subject>Cytokines - metabolism</subject><subject>Deprivation</subject><subject>Disease Models, Animal</subject><subject>FDA approval</subject><subject>Fibroblast growth factor 2</subject><subject>Filopodia</subject><subject>Glucose</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Life Sciences & Biomedicine</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Mesenchyme</subject><subject>middle cerebral artery occlusion</subject><subject>Mitochondria</subject><subject>Neural stem cells</subject><subject>Occlusion</subject><subject>Physical Sciences</subject><subject>Progenitor cells</subject><subject>Recovery of function</subject><subject>regenerative medicine</subject><subject>Review</subject><subject>Science & Technology</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Stroke - metabolism</subject><subject>Stroke - therapy</subject><subject>Studies</subject><subject>Transplantation</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNqNkUtvEzEUhUcIREthxxqNxAYJBvx-bJDa4VWphEXL2nI8163DZBzsmVT99zhJiVJWrHx1_fnc43uq6iVG7ynV6ENYLDPBSBHF-KPqGDNCGoSEfHxQH1XPcl4gRCjh-ml1RDeFwvS4mp3FAervNqV423yCFNbQ1bP2skG4bqHvc33are3goLb1LK6h33abM5sLd3UDya7uah9TfTmm-AueV0-87TO8uD9Pqp9fPl-135qLH1_P29OLxjGpxoZpLBz3iKo5EV3xQlWnEVZKzoWfC6qcKA6VBQ-IM-2Jdg4EZRh3SnZI05PqfKfbRbswqxSWNt2ZaIPZNmK6NjaNwfVgFNJFWJRn3JfhUmGgmnMEvvPSW1q0Pu60VtN8CZ2DYUy2fyD68GYIN-Y6ro0kmFO2EXhzL5Di7wnyaJYhu7ImO0CcsiFUMyWF5KSgr_9BF3FKQ1nVlmKMaCoL9W5HuRRzTuD3ZjAym9DNYegFf3X4gT38N-UCvN0BtzCPPrsAJdA9hhDilHPBKSoRbKar_6fbMNoxxKGN0zDSP-oSxQI</recordid><startdate>20200419</startdate><enddate>20200419</enddate><creator>Brown, John</creator><creator>Park, You Jeong</creator><creator>Lee, Jea-Young</creator><creator>Chase, Thomas N.</creator><creator>Koga, Minako</creator><creator>Borlongan, Cesar V.</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2966-9782</orcidid><orcidid>https://orcid.org/0000-0001-5270-3224</orcidid></search><sort><creationdate>20200419</creationdate><title>Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke</title><author>Brown, John ; Park, You Jeong ; Lee, Jea-Young ; Chase, Thomas N. ; Koga, Minako ; Borlongan, Cesar V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-4916c5f038b26d32538d901887b6fb638c62328aefe0549f29cce63411d87d093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>basic fibroblast growth factor</topic><topic>Biochemistry & Molecular Biology</topic><topic>Biomarkers</topic><topic>Bone marrow</topic><topic>Brain Ischemia - complications</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell- and Tissue-Based Therapy - methods</topic><topic>Cerebral blood flow</topic><topic>cerebral ischemia</topic><topic>Chemistry</topic><topic>Chemistry, Multidisciplinary</topic><topic>Clinical trials</topic><topic>Consortia</topic><topic>Cytokines - metabolism</topic><topic>Deprivation</topic><topic>Disease Models, Animal</topic><topic>FDA approval</topic><topic>Fibroblast growth factor 2</topic><topic>Filopodia</topic><topic>Glucose</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Life Sciences & Biomedicine</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>Mesenchyme</topic><topic>middle cerebral artery occlusion</topic><topic>Mitochondria</topic><topic>Neural stem cells</topic><topic>Occlusion</topic><topic>Physical Sciences</topic><topic>Progenitor cells</topic><topic>Recovery of function</topic><topic>regenerative medicine</topic><topic>Review</topic><topic>Science & Technology</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stroke</topic><topic>Stroke - etiology</topic><topic>Stroke - metabolism</topic><topic>Stroke - therapy</topic><topic>Studies</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, John</creatorcontrib><creatorcontrib>Park, You Jeong</creatorcontrib><creatorcontrib>Lee, Jea-Young</creatorcontrib><creatorcontrib>Chase, Thomas N.</creatorcontrib><creatorcontrib>Koga, Minako</creatorcontrib><creatorcontrib>Borlongan, Cesar V.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, John</au><au>Park, You Jeong</au><au>Lee, Jea-Young</au><au>Chase, Thomas N.</au><au>Koga, Minako</au><au>Borlongan, Cesar V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke</atitle><jtitle>International journal of molecular sciences</jtitle><stitle>INT J MOL SCI</stitle><addtitle>Int J Mol Sci</addtitle><date>2020-04-19</date><risdate>2020</risdate><volume>21</volume><issue>8</issue><spage>2845</spage><pages>2845-</pages><artnum>2845</artnum><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells' ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32325813</pmid><doi>10.3390/ijms21082845</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2966-9782</orcidid><orcidid>https://orcid.org/0000-0001-5270-3224</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2020-04, Vol.21 (8), p.2845, Article 2845 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2394876752 |
| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals basic fibroblast growth factor Biochemistry & Molecular Biology Biomarkers Bone marrow Brain Ischemia - complications Cell Line Cell lines Cell- and Tissue-Based Therapy - methods Cerebral blood flow cerebral ischemia Chemistry Chemistry, Multidisciplinary Clinical trials Consortia Cytokines - metabolism Deprivation Disease Models, Animal FDA approval Fibroblast growth factor 2 Filopodia Glucose Growth factors Humans Inflammation Interleukin 6 Ischemia Kinases Life Sciences & Biomedicine Mesenchymal Stem Cell Transplantation - methods mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme middle cerebral artery occlusion Mitochondria Neural stem cells Occlusion Physical Sciences Progenitor cells Recovery of function regenerative medicine Review Science & Technology Stem cell transplantation Stem cells Stroke Stroke - etiology Stroke - metabolism Stroke - therapy Studies Transplantation |
| title | Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T12%3A32%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20Marrow-Derived%20NCS-01%20Cells%20Advance%20a%20Novel%20Cell-Based%20Therapy%20for%20Stroke&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Brown,%20John&rft.date=2020-04-19&rft.volume=21&rft.issue=8&rft.spage=2845&rft.pages=2845-&rft.artnum=2845&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms21082845&rft_dat=%3Cproquest_pubme%3E2394876752%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2394442937&rft_id=info:pmid/32325813&rft_doaj_id=oai_doaj_org_article_80918867d05f478781e39550efdf7fa3&rfr_iscdi=true |