pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy
To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which thei...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-05, Vol.15 (11), p.1097-1112 |
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| container_title | Nanomedicine (London, England) |
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| creator | Zhang, Guiyang Gou, Huilin Liu, Yanfeng Xi, Kai Jiang, Dechen Jia, Xudong |
| description | To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy.
The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated.
The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues.
The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option. |
| doi_str_mv | 10.2217/nnm-2020-0022 |
| format | Article |
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The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated.
The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues.
The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2020-0022</identifier><identifier>PMID: 32326820</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Acids ; Biocompatibility ; Cancer therapies ; Cell Line, Tumor ; Chitosan ; Combination therapy ; Ethanol ; Ferric Compounds ; Heat ; Hydrogen-Ion Concentration ; Iron ; iron oxide ; Lasers ; low-power laser ; Nanoparticles ; PDT/PTT ; PEG ; Photochemotherapy ; Photosensitizing Agents - therapeutic use ; Phototherapy ; self-assembly</subject><ispartof>Nanomedicine (London, England), 2020-05, Vol.15 (11), p.1097-1112</ispartof><rights>2020 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd May 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-fbf1519ea000b12cf7b6c13c484af173f47a048a485c38758e35ac0b24e997943</citedby><cites>FETCH-LOGICAL-c371t-fbf1519ea000b12cf7b6c13c484af173f47a048a485c38758e35ac0b24e997943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32326820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Guiyang</creatorcontrib><creatorcontrib>Gou, Huilin</creatorcontrib><creatorcontrib>Liu, Yanfeng</creatorcontrib><creatorcontrib>Xi, Kai</creatorcontrib><creatorcontrib>Jiang, Dechen</creatorcontrib><creatorcontrib>Jia, Xudong</creatorcontrib><title>pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy.
The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated.
The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues.
The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.</description><subject>Acids</subject><subject>Biocompatibility</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Chitosan</subject><subject>Combination therapy</subject><subject>Ethanol</subject><subject>Ferric Compounds</subject><subject>Heat</subject><subject>Hydrogen-Ion Concentration</subject><subject>Iron</subject><subject>iron oxide</subject><subject>Lasers</subject><subject>low-power laser</subject><subject>Nanoparticles</subject><subject>PDT/PTT</subject><subject>PEG</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Phototherapy</subject><subject>self-assembly</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kT1vFDEQhq2IiHxAmRatRENjzl-7tksUQoIUKVccteX1jXWOdu3F3iW5f48vFyiQqDzWPPNqNA9CV5R8ZozKVYwjZoQRTAhjJ-icSqFwpzv-5qXmuFVKn6GLUh4JaRWj5C0644yzTjFyjuJ0hzOUKcUSfkGzvrnFbhfmVGxchZxik57DFprdvs9h20Qbky0Fxn4IUBqfcjOkJzylJ8hNbYQyw7ZZf92s1ptN49LYh2jnUGPmHWQ77d-hU2-HAu9f30v049vN5voO3z_cfr_-co8dl3TGvve0pRosIaSnzHnZd45yJ5SwnkruhbREKCtU67iSrQLeWkd6JkBrqQW_RJ-OuVNOPxcosxlDcTAMNkJaimFcCyW7VnYV_fgP-piWHOt2hlVGcK0UqRQ-Ui6nUjJ4M-Uw2rw3lJiDCFNFmIMIcxBR-Q-vqUs_wvYv_efyFdBHwC_zUg24ANGBOf7qRHAhwn_CfwPNdZdu</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Zhang, Guiyang</creator><creator>Gou, Huilin</creator><creator>Liu, Yanfeng</creator><creator>Xi, Kai</creator><creator>Jiang, Dechen</creator><creator>Jia, Xudong</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy</title><author>Zhang, Guiyang ; Gou, Huilin ; Liu, Yanfeng ; Xi, Kai ; Jiang, Dechen ; Jia, Xudong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-fbf1519ea000b12cf7b6c13c484af173f47a048a485c38758e35ac0b24e997943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Biocompatibility</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Chitosan</topic><topic>Combination therapy</topic><topic>Ethanol</topic><topic>Ferric Compounds</topic><topic>Heat</topic><topic>Hydrogen-Ion Concentration</topic><topic>Iron</topic><topic>iron oxide</topic><topic>Lasers</topic><topic>low-power laser</topic><topic>Nanoparticles</topic><topic>PDT/PTT</topic><topic>PEG</topic><topic>Photochemotherapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Phototherapy</topic><topic>self-assembly</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Guiyang</creatorcontrib><creatorcontrib>Gou, Huilin</creatorcontrib><creatorcontrib>Liu, Yanfeng</creatorcontrib><creatorcontrib>Xi, Kai</creatorcontrib><creatorcontrib>Jiang, Dechen</creatorcontrib><creatorcontrib>Jia, Xudong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Guiyang</au><au>Gou, Huilin</au><au>Liu, Yanfeng</au><au>Xi, Kai</au><au>Jiang, Dechen</au><au>Jia, Xudong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>15</volume><issue>11</issue><spage>1097</spage><epage>1112</epage><pages>1097-1112</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy.
The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated.
The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues.
The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>32326820</pmid><doi>10.2217/nnm-2020-0022</doi><tpages>16</tpages></addata></record> |
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| subjects | Acids Biocompatibility Cancer therapies Cell Line, Tumor Chitosan Combination therapy Ethanol Ferric Compounds Heat Hydrogen-Ion Concentration Iron iron oxide Lasers low-power laser Nanoparticles PDT/PTT PEG Photochemotherapy Photosensitizing Agents - therapeutic use Phototherapy self-assembly |
| title | pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy |
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