The molecular functions of common and atypical MLL fusion protein complexes

Mixed-lineage leukemia (MLL) fuses with a variety of partners to produce a functionally altered MLL complex that is not expressed in normal cells, which transforms normal hematopoietic progenitors into leukemia cells. Because more than 80 fusion partners have been identified to date, the molecular f...

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Veröffentlicht in:	Biochimica et biophysica acta. Gene regulatory mechanisms 2020-07, Vol.1863 (7), p.194548-194548, Article 194548
Hauptverfasser:	Takahashi, Satoshi, Yokoyama, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Histone acetyltransferase Histone methyltransferase Leukemia MLL Protein complex Transcription
Online-Zugang:	Volltext
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