Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis

Osteoarthritis (OA), a disease of the entire joint, is characterized by abnormal bone remodeling and coalescent degradation of articular cartilage. We have previously found that elevated levels of H‐type vessels in subchondral bone correlate with OA and that focal adhesion kinase (FAK) is critical f...

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Veröffentlicht in:	Journal of cellular physiology 2020-11, Vol.235 (11), p.8653-8666
Hauptverfasser:	Wu, Hangtian, Xu, Ting, Chen, Zhigang, Wang, Yutian, Li, Kaiqun, Chen, Pei‐Sheng, Yao, Zilong, Su, Jianwen, Cheng, Caiyu, Wu, Xiaohu, Zhang, Hongan, Chai, Yu, Zhang, Xianrong, Hu, Yanjun, Yu, Bin, Cui, Zhuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alendronate - pharmacology Angiogenesis Animals Anterior cruciate ligament Anterior Cruciate Ligament - pathology Antibodies Arthritis Biomedical materials Blood vessels Bone and Bones - pathology Bone growth Bone remodeling Bone Remodeling - drug effects Bone Remodeling - physiology Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - metabolism Chondrocytes Chondrocytes - metabolism Degeneration Disease Models, Animal Endothelial cells Endothelial Cells - drug effects FAK Focal adhesion kinase Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - drug effects Focal Adhesion Protein-Tyrosine Kinases - metabolism Growth factors H‐type vessels Kinases Male Mesenchyme Ossification (ectopic) Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - pathology Osteogenesis Osteoporosis Pathogenesis Protein kinase Proteins Rats, Sprague-Dawley Signaling Stem cell transplantation Stem cells Subchondral bone Vascular endothelial growth factor Y15
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