Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene
The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome‐wide asso...
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| Veröffentlicht in: | New directions for child and adolescent development 2020-01, Vol.2020 (169), p.131-155 |
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| container_title | New directions for child and adolescent development |
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| creator | Rakhlin, Natalia Landi, Nicole Lee, Maria Magnuson, James S. Naumova, Oxana Yu Ovchinnikova, Irina V. Grigorenko, Elena L. |
| description | The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome‐wide association study of DLD in a geographically isolated population, and brain network‐based endophenotypes of functional intracortical coherence between major language‐related brain areas. We analyzed electroencephalogram (EEG) data from thirty‐nine children (twenty‐three with, sixteen without DLD) aged 7.17–15.83 years acquired during an auditory picture–word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p = .00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1. |
| doi_str_mv | 10.1002/cad.20331 |
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| source | Wiley Online Library Journals Frontfile Complete; Sociological Abstracts; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adolescents Auditory Stimuli Brain Brain Hemisphere Functions Children Coherence Correlation Developmental Delays Developmental Disabilities Diagnostic Tests Electroencephalography Etiology Genetics Genomics Geographic Isolation Language disorders Language Impairments Pictorial Stimuli Polymorphism Social cohesion Task Analysis Vocabulary |
| title | Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene |
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