How does temperature play a role in the storage of extracellular vesicles?
Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of...
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| Veröffentlicht in: | Journal of cellular physiology 2020-11, Vol.235 (11), p.7663-7680 |
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| container_title | Journal of cellular physiology |
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| creator | Qin, Bo Zhang, Qi Hu, Xi‐min Mi, Tuo‐yang Yu, Hai‐yang Liu, Shen‐shen Zhang, Bin Tang, Mu Huang, Ju‐fang Xiong, Kun |
| description | Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. This review summarizes the storage practices of EVs in recent years, and explains the impact of temperature on the quality and stability of EVs during storage based on current research, and explains the potential mechanisms involved in this effect as much as possible.
Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. Here, we briefly review EVs' biogenesis, contents, subtypes and effect of storage temperature on its quality and stability, as well as application of cryoprotectants in EVs cryopreservation, and specifically focus on the mechanism by which storage temperature affects the quality and stability of EVs. |
| doi_str_mv | 10.1002/jcp.29700 |
| format | Article |
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Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. Here, we briefly review EVs' biogenesis, contents, subtypes and effect of storage temperature on its quality and stability, as well as application of cryoprotectants in EVs cryopreservation, and specifically focus on the mechanism by which storage temperature affects the quality and stability of EVs.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29700</identifier><identifier>PMID: 32324279</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Cryopreservation - methods ; cryoprotectants ; exosomes ; Extracellular vesicles ; Extracellular Vesicles - chemistry ; Extracellular Vesicles - metabolism ; Humans ; Lipids ; Nucleic acids ; Protein Stability ; Shelf life ; storage ; Temperature ; Temperature effects ; Vesicles</subject><ispartof>Journal of cellular physiology, 2020-11, Vol.235 (11), p.7663-7680</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-1e90ddb1a97da51693aae788c5dcf71331196532e7728b3949be06e1d39c66af3</citedby><cites>FETCH-LOGICAL-c3530-1e90ddb1a97da51693aae788c5dcf71331196532e7728b3949be06e1d39c66af3</cites><orcidid>0000-0002-7525-9207</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.29700$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.29700$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32324279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Bo</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Hu, Xi‐min</creatorcontrib><creatorcontrib>Mi, Tuo‐yang</creatorcontrib><creatorcontrib>Yu, Hai‐yang</creatorcontrib><creatorcontrib>Liu, Shen‐shen</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Tang, Mu</creatorcontrib><creatorcontrib>Huang, Ju‐fang</creatorcontrib><creatorcontrib>Xiong, Kun</creatorcontrib><title>How does temperature play a role in the storage of extracellular vesicles?</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. This review summarizes the storage practices of EVs in recent years, and explains the impact of temperature on the quality and stability of EVs during storage based on current research, and explains the potential mechanisms involved in this effect as much as possible.
Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. Here, we briefly review EVs' biogenesis, contents, subtypes and effect of storage temperature on its quality and stability, as well as application of cryoprotectants in EVs cryopreservation, and specifically focus on the mechanism by which storage temperature affects the quality and stability of EVs.</description><subject>Animals</subject><subject>Cryopreservation - methods</subject><subject>cryoprotectants</subject><subject>exosomes</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - chemistry</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Humans</subject><subject>Lipids</subject><subject>Nucleic acids</subject><subject>Protein Stability</subject><subject>Shelf life</subject><subject>storage</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>Vesicles</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQJRYY0vorcTwhVAGlqgQDzJaTXCBVWgc7ofTf4xJgQGK64Z5779WD0CklY0oImyzzZsyUJGQPDSlRMhJJzPbRMOxopGJBB-jI-yUhRCnOD9GAM84Ek2qI5jO7wYUFj1tYNeBM2znATW222GBna8DVGrevgH1rnXkBbEsMH60zOdR1VxuH38FXeQ3-6hgdlKb2cPI9R-j59uZpOosWD3f30-tFlPOYk4iCIkWRUaNkYWKaKG4MyDTN4yIvJeWcUpXEnIGULM24EioDkgAtuMqTxJR8hC763MbZtw58q1eV39Uxa7Cd1yzcMMHTlAX0_A-6tJ1bh3aaCSFkeB6rQF32VO6s9w5K3bhqZdxWU6J3gnUQrL8EB_bsO7HLVlD8kj9GAzDpgU1Vw_b_JD2fPvaRn3JDgwo</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Qin, Bo</creator><creator>Zhang, Qi</creator><creator>Hu, Xi‐min</creator><creator>Mi, Tuo‐yang</creator><creator>Yu, Hai‐yang</creator><creator>Liu, Shen‐shen</creator><creator>Zhang, Bin</creator><creator>Tang, Mu</creator><creator>Huang, Ju‐fang</creator><creator>Xiong, Kun</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7525-9207</orcidid></search><sort><creationdate>202011</creationdate><title>How does temperature play a role in the storage of extracellular vesicles?</title><author>Qin, Bo ; 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Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. Here, we briefly review EVs' biogenesis, contents, subtypes and effect of storage temperature on its quality and stability, as well as application of cryoprotectants in EVs cryopreservation, and specifically focus on the mechanism by which storage temperature affects the quality and stability of EVs.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32324279</pmid><doi>10.1002/jcp.29700</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-7525-9207</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Cryopreservation - methods cryoprotectants exosomes Extracellular vesicles Extracellular Vesicles - chemistry Extracellular Vesicles - metabolism Humans Lipids Nucleic acids Protein Stability Shelf life storage Temperature Temperature effects Vesicles |
| title | How does temperature play a role in the storage of extracellular vesicles? |
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