Neuroprotective effect of melatonin on radiation‐induced oxidative stress and apoptosis in the brainstem of rats

This study aimed to determine the effects of melatonin on irradiation‐induced apoptosis and oxidative stress in the brainstem region of Wistar rats. Therefore, the animals underwent whole‐brain X‐radiation with a single dose of 25 Gy in the presence or absence of melatonin pretreatment at a concentr...

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Veröffentlicht in:	Journal of cellular physiology 2020-11, Vol.235 (11), p.8791-8798
Hauptverfasser:	Motallebzadeh, Elham, Tameh, Abolfazl Azami, Zavareh, Sayyed Alireza Talaei, Farhood, Bagher, Aliasgharzedeh, Akbar, Mohseni, Mehran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Brain stem Brain Stem - drug effects Brain Stem - metabolism brainstem Caspase Catalase Clinical trials Enzymatic activity Glutathione Glutathione peroxidase Glutathione Peroxidase - drug effects Glutathione Peroxidase - metabolism ionizing radiation Irradiation Male Malondialdehyde Malondialdehyde - metabolism Melatonin Melatonin - therapeutic use Neuroprotection Neuroprotective Agents - pharmacology Nitric oxide Oxidative stress Oxidative Stress - drug effects Peroxidase Pretreatment Radiation dosage Rats, Wistar Superoxide dismutase Superoxide Dismutase - metabolism X-rays
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