Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women
Background and Objective Thyrotoxicosis is associated with accelerated bone turnover and increases the risk of fractures and osteoporosis. Graves' disease is the most common cause of hyperthyroidism. However, studies that examined risk factors associated with fragility fractures only in patient...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2020-08, Vol.93 (2), p.204-211 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 211 |
|---|---|
| container_issue | 2 |
| container_start_page | 204 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 93 |
| creator | Takedani, Kai Notsu, Masakazu Yamauchi, Mika Nawata, Kiyoko Sugimoto, Toshitsugu Kanasaki, Keizo |
| description | Background and Objective
Thyrotoxicosis is associated with accelerated bone turnover and increases the risk of fractures and osteoporosis. Graves' disease is the most common cause of hyperthyroidism. However, studies that examined risk factors associated with fragility fractures only in patients with Graves' disease are limited. Here, we investigated whether the risk of vertebral fracture (VF) of postmenopausal Graves' disease patients is high and tried to identify the risk factors for VF in that population.
Design and Methods
Forty‐three postmenopausal women with Graves' disease were enrolled. Physical and biochemical indices, thyroid indices and bone mineral density (BMD) were measured, and lateral X‐rays were obtained to evaluate VFs. Age‐ and sex‐matched healthy individuals were enrolled as the control group (n = 86).
Results
The prevalence of VFs (35% vs 17%, P |
| doi_str_mv | 10.1111/cen.14208 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2394243861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2424637396</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4198-fd24d54d72cfc60f3e5eafc19a2f3b1422f09466d58676c1cc7320bcdb941dbc3</originalsourceid><addsrcrecordid>eNp1kDtOxDAQhi0EguVRcAFkiQaKgF9xEjq0Wh7SCiigobEcewyBbBLshBUd1-B6nATDAgUS04xG-ubXzIfQNiUHNNahgeaACkbyJTSiXKYJYzJdRiPCCUmIlGINrYfwQAhJc5KtojXOOBMsz0fo9tTrZwjvr2_YVgF0AKwbi5_B91B6XWPntekHD0f4qg2hKmvAne7v2ztoKoPrqnnEVYO7NvQzaNpODyEuzds4bKIVp-sAW999A92cTK7HZ8n08vR8fDxNjKBFnjjLhE2FzZhxRhLHIQXtDC00c7yMbzFHCiGlTXOZSUONyTgjpbFlIagtDd9Ae4vczrdPA4RezapgoK51A-0QFOOFYILnkkZ09w_60A6-idep6ENInvFCRmp_QRkfX_bgVOermfYvihL1KVxF4epLeGR3vhOHcgb2l_wxHIHDBTCvanj5P0mNJxeLyA9Xy4sz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424637396</pqid></control><display><type>article</type><title>Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Takedani, Kai ; Notsu, Masakazu ; Yamauchi, Mika ; Nawata, Kiyoko ; Sugimoto, Toshitsugu ; Kanasaki, Keizo</creator><creatorcontrib>Takedani, Kai ; Notsu, Masakazu ; Yamauchi, Mika ; Nawata, Kiyoko ; Sugimoto, Toshitsugu ; Kanasaki, Keizo</creatorcontrib><description>Background and Objective
Thyrotoxicosis is associated with accelerated bone turnover and increases the risk of fractures and osteoporosis. Graves' disease is the most common cause of hyperthyroidism. However, studies that examined risk factors associated with fragility fractures only in patients with Graves' disease are limited. Here, we investigated whether the risk of vertebral fracture (VF) of postmenopausal Graves' disease patients is high and tried to identify the risk factors for VF in that population.
Design and Methods
Forty‐three postmenopausal women with Graves' disease were enrolled. Physical and biochemical indices, thyroid indices and bone mineral density (BMD) were measured, and lateral X‐rays were obtained to evaluate VFs. Age‐ and sex‐matched healthy individuals were enrolled as the control group (n = 86).
Results
The prevalence of VFs (35% vs 17%, P < .05), osteoporosis (63% vs 33%, P < .01) and severe osteoporosis (40% vs 17%, P < .01) was significantly higher in the Graves' disease group. Although there was no significant difference in either thyroid hormone levels or the positive ratio of thyroid antibodies, the prevalence of thyroid‐stimulating antibody (TSAb) was significantly higher in Graves' disease patients with VF compared to without (100% vs 68%, P < .05). Multivariate logistic regression analyses adjusted for age identified Graves' disease as being associated with the presence of VFs (OR 2.72, 95% CI: 1.13‐6.54, P < .05) in postmenopausal women.
Conclusions
Postmenopausal Graves' disease patients had high risks of VF and severe osteoporosis. TSAb could be involved as a risk factor for VF in postmenopausal Graves' disease.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.14208</identifier><identifier>PMID: 32324288</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>bone ; Bone mineral density ; Bone turnover ; disease ; Fractures ; Graves ; Graves disease ; Health risk assessment ; Hyperthyroidism ; immunoglobulins ; menopause ; Osteoporosis ; Post-menopause ; Risk factors ; Thyroid ; Thyroid gland ; thyroid‐stimulating ; Thyrotoxicosis ; Vertebrae</subject><ispartof>Clinical endocrinology (Oxford), 2020-08, Vol.93 (2), p.204-211</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4198-fd24d54d72cfc60f3e5eafc19a2f3b1422f09466d58676c1cc7320bcdb941dbc3</citedby><cites>FETCH-LOGICAL-c4198-fd24d54d72cfc60f3e5eafc19a2f3b1422f09466d58676c1cc7320bcdb941dbc3</cites><orcidid>0000-0002-8326-8154 ; 0000-0002-1525-325X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.14208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.14208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32324288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takedani, Kai</creatorcontrib><creatorcontrib>Notsu, Masakazu</creatorcontrib><creatorcontrib>Yamauchi, Mika</creatorcontrib><creatorcontrib>Nawata, Kiyoko</creatorcontrib><creatorcontrib>Sugimoto, Toshitsugu</creatorcontrib><creatorcontrib>Kanasaki, Keizo</creatorcontrib><title>Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Background and Objective
Thyrotoxicosis is associated with accelerated bone turnover and increases the risk of fractures and osteoporosis. Graves' disease is the most common cause of hyperthyroidism. However, studies that examined risk factors associated with fragility fractures only in patients with Graves' disease are limited. Here, we investigated whether the risk of vertebral fracture (VF) of postmenopausal Graves' disease patients is high and tried to identify the risk factors for VF in that population.
Design and Methods
Forty‐three postmenopausal women with Graves' disease were enrolled. Physical and biochemical indices, thyroid indices and bone mineral density (BMD) were measured, and lateral X‐rays were obtained to evaluate VFs. Age‐ and sex‐matched healthy individuals were enrolled as the control group (n = 86).
Results
The prevalence of VFs (35% vs 17%, P < .05), osteoporosis (63% vs 33%, P < .01) and severe osteoporosis (40% vs 17%, P < .01) was significantly higher in the Graves' disease group. Although there was no significant difference in either thyroid hormone levels or the positive ratio of thyroid antibodies, the prevalence of thyroid‐stimulating antibody (TSAb) was significantly higher in Graves' disease patients with VF compared to without (100% vs 68%, P < .05). Multivariate logistic regression analyses adjusted for age identified Graves' disease as being associated with the presence of VFs (OR 2.72, 95% CI: 1.13‐6.54, P < .05) in postmenopausal women.
Conclusions
Postmenopausal Graves' disease patients had high risks of VF and severe osteoporosis. TSAb could be involved as a risk factor for VF in postmenopausal Graves' disease.</description><subject>bone</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>disease</subject><subject>Fractures</subject><subject>Graves</subject><subject>Graves disease</subject><subject>Health risk assessment</subject><subject>Hyperthyroidism</subject><subject>immunoglobulins</subject><subject>menopause</subject><subject>Osteoporosis</subject><subject>Post-menopause</subject><subject>Risk factors</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>thyroid‐stimulating</subject><subject>Thyrotoxicosis</subject><subject>Vertebrae</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kDtOxDAQhi0EguVRcAFkiQaKgF9xEjq0Wh7SCiigobEcewyBbBLshBUd1-B6nATDAgUS04xG-ubXzIfQNiUHNNahgeaACkbyJTSiXKYJYzJdRiPCCUmIlGINrYfwQAhJc5KtojXOOBMsz0fo9tTrZwjvr2_YVgF0AKwbi5_B91B6XWPntekHD0f4qg2hKmvAne7v2ztoKoPrqnnEVYO7NvQzaNpODyEuzds4bKIVp-sAW999A92cTK7HZ8n08vR8fDxNjKBFnjjLhE2FzZhxRhLHIQXtDC00c7yMbzFHCiGlTXOZSUONyTgjpbFlIagtDd9Ae4vczrdPA4RezapgoK51A-0QFOOFYILnkkZ09w_60A6-idep6ENInvFCRmp_QRkfX_bgVOermfYvihL1KVxF4epLeGR3vhOHcgb2l_wxHIHDBTCvanj5P0mNJxeLyA9Xy4sz</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Takedani, Kai</creator><creator>Notsu, Masakazu</creator><creator>Yamauchi, Mika</creator><creator>Nawata, Kiyoko</creator><creator>Sugimoto, Toshitsugu</creator><creator>Kanasaki, Keizo</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8326-8154</orcidid><orcidid>https://orcid.org/0000-0002-1525-325X</orcidid></search><sort><creationdate>202008</creationdate><title>Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women</title><author>Takedani, Kai ; Notsu, Masakazu ; Yamauchi, Mika ; Nawata, Kiyoko ; Sugimoto, Toshitsugu ; Kanasaki, Keizo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4198-fd24d54d72cfc60f3e5eafc19a2f3b1422f09466d58676c1cc7320bcdb941dbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>bone</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>disease</topic><topic>Fractures</topic><topic>Graves</topic><topic>Graves disease</topic><topic>Health risk assessment</topic><topic>Hyperthyroidism</topic><topic>immunoglobulins</topic><topic>menopause</topic><topic>Osteoporosis</topic><topic>Post-menopause</topic><topic>Risk factors</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>thyroid‐stimulating</topic><topic>Thyrotoxicosis</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takedani, Kai</creatorcontrib><creatorcontrib>Notsu, Masakazu</creatorcontrib><creatorcontrib>Yamauchi, Mika</creatorcontrib><creatorcontrib>Nawata, Kiyoko</creatorcontrib><creatorcontrib>Sugimoto, Toshitsugu</creatorcontrib><creatorcontrib>Kanasaki, Keizo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takedani, Kai</au><au>Notsu, Masakazu</au><au>Yamauchi, Mika</au><au>Nawata, Kiyoko</au><au>Sugimoto, Toshitsugu</au><au>Kanasaki, Keizo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2020-08</date><risdate>2020</risdate><volume>93</volume><issue>2</issue><spage>204</spage><epage>211</epage><pages>204-211</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Background and Objective
Thyrotoxicosis is associated with accelerated bone turnover and increases the risk of fractures and osteoporosis. Graves' disease is the most common cause of hyperthyroidism. However, studies that examined risk factors associated with fragility fractures only in patients with Graves' disease are limited. Here, we investigated whether the risk of vertebral fracture (VF) of postmenopausal Graves' disease patients is high and tried to identify the risk factors for VF in that population.
Design and Methods
Forty‐three postmenopausal women with Graves' disease were enrolled. Physical and biochemical indices, thyroid indices and bone mineral density (BMD) were measured, and lateral X‐rays were obtained to evaluate VFs. Age‐ and sex‐matched healthy individuals were enrolled as the control group (n = 86).
Results
The prevalence of VFs (35% vs 17%, P < .05), osteoporosis (63% vs 33%, P < .01) and severe osteoporosis (40% vs 17%, P < .01) was significantly higher in the Graves' disease group. Although there was no significant difference in either thyroid hormone levels or the positive ratio of thyroid antibodies, the prevalence of thyroid‐stimulating antibody (TSAb) was significantly higher in Graves' disease patients with VF compared to without (100% vs 68%, P < .05). Multivariate logistic regression analyses adjusted for age identified Graves' disease as being associated with the presence of VFs (OR 2.72, 95% CI: 1.13‐6.54, P < .05) in postmenopausal women.
Conclusions
Postmenopausal Graves' disease patients had high risks of VF and severe osteoporosis. TSAb could be involved as a risk factor for VF in postmenopausal Graves' disease.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32324288</pmid><doi>10.1111/cen.14208</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8326-8154</orcidid><orcidid>https://orcid.org/0000-0002-1525-325X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2020-08, Vol.93 (2), p.204-211 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2394243861 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | bone Bone mineral density Bone turnover disease Fractures Graves Graves disease Health risk assessment Hyperthyroidism immunoglobulins menopause Osteoporosis Post-menopause Risk factors Thyroid Thyroid gland thyroid‐stimulating Thyrotoxicosis Vertebrae |
| title | Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T01%3A44%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Graves%E2%80%99%20disease%20and%20vertebral%20fracture:%20Possible%20pathogenic%20link%20in%20postmenopausal%20women&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Takedani,%20Kai&rft.date=2020-08&rft.volume=93&rft.issue=2&rft.spage=204&rft.epage=211&rft.pages=204-211&rft.issn=0300-0664&rft.eissn=1365-2265&rft_id=info:doi/10.1111/cen.14208&rft_dat=%3Cproquest_cross%3E2424637396%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2424637396&rft_id=info:pmid/32324288&rfr_iscdi=true |