Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes

ObjectiveBacterial translocation to various organs including human adipose tissue (AT) due to increased intestinal permeability remains poorly understood. We hypothesised that: (1) bacterial presence is highly tissue specific and (2) related in composition and quantity to immune inflammatory and met...

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Veröffentlicht in:	Gut 2020-10, Vol.69 (10), p.1796-1806
Hauptverfasser:	Massier, Lucas, Chakaroun, Rima, Tabei, Shirin, Crane, Alyce, Didt, Konrad David, Fallmann, Jörg, von Bergen, Martin, Haange, Sven-Bastiaan, Heyne, Henrike, Stumvoll, Michael, Gericke, Martin, Dietrich, Arne, Blüher, Matthias, Musat, Niculina, Kovacs, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Adipose Tissue - immunology Adipose Tissue - microbiology Antibiotics Bacteria bacterial translocation Bacterial Translocation - immunology Body fat Cells, Cultured Complications Contaminants Deoxyribonucleic acid Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology DNA DNA, Bacterial - isolation & purification Female Firmicutes - isolation & purification Fluorescence in situ hybridization Gastrointestinal surgery Gut microbiota Humans Inflammation Inflammation - immunology Insulin resistance Interleukin 6 Interleukin-6 - metabolism Intestinal Mucosa - metabolism intestinal permeability Intestine Male Metabolic disorders Microbiota Middle Aged Obesity Obesity - complications Obesity - immunology obesity surgery Permeability Proteobacteria - isolation & purification RNA, Ribosomal, 16S - blood rRNA 16S Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF
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