Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI
Background and purpose Imaging-based diagnostic systems play important roles in hepatocellular carcinoma (HCC). We aimed to compare the diagnostic performance of recently updated imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced magnetic resonance imaging (MRI). Methods 493 nodules...
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| Veröffentlicht in: | Hepatology international 2020-07, Vol.14 (4), p.534-543 |
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| description | Background and purpose
Imaging-based diagnostic systems play important roles in hepatocellular carcinoma (HCC). We aimed to compare the diagnostic performance of recently updated imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced magnetic resonance imaging (MRI).
Methods
493 nodules (399 HCCs, 24 other malignancies, 70 benign) 1.0–3.0 cm from 400 patients, including 322 male (mean age 59.3 ± 9.4 years) and 78 female (mean age 61.2 ± 9.0 years), at risk for HCC who underwent gadoxetate disodium-enhanced MRI between July 2015 and December 2016 were retrospectively evaluated. Final diagnosis was determined histopathologically or clinically. The sensitivity and specificity in diagnosing HCC of the latest versions of four imaging criteria [Liver Imaging Reporting and Data System (LI-RADS), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), Korean Liver Cancer Association-National Cancer Center (KLCA-NCC)] were compared using generalized estimating equations.
Results
In 331 only pathologically diagnosed nodules, the sensitivities of both the APASL (86.8%) and KLCA-NCC criteria (85.4%) were significantly higher than the sensitivities of the EASL (71.8%) and LR-5 (71.1%) criteria (
p
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| doi_str_mv | 10.1007/s12072-020-10040-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2393039950</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2424465095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-2127662e974aacc1d613d0586c2f0dd5a77c3ece2024c905a0d56d7f8f78c6c13</originalsourceid><addsrcrecordid>eNp9kU9uGyEUh1GVqnbdXqCLCimbbiZ5wACeZTTKPylRpCpdIwrMBMszODAjxbtsc4sucpIeJScprhNHyiIb4Ol9fA_xQ-gbgQMCIA8ToSBpARSKXJdQ0A9oSiomCuAl2dudGZugzyktADgXRHxCE0YZKYkkU7SuQ7fS0afQ49Dg4cZh63XbhzR4g1cuNiF2ujdu0_Wdbn3fYhP94KLXODfxWV2np_uHp4fHvLID-PvHdDjbWm3DnRv0sDGmYP3YFa6_2bgsvvx5_gV9bPQyua_P-wz9Ojm-rs-Ki6vT8_roojBM8qGghEohqKtkqbUxxArCLPC5MLQBa7mW0jBnHAVamgq4BsuFlc28kXMjDGEz9GPrXcVwO7o0qM4n45ZL3bswJkVZxYBVFYeM7r9BF2GMfX6doiUtS8Gh4pmiW8rEkFJ0jVrF_DNxrQioTTBqG4zKwaj_weQZM_T9WT3-7pzdXXlJIgNsC6Tc6lsXX2e_o_0Hx_KbXQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2424465095</pqid></control><display><type>article</type><title>Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Byun, Jieun ; Choi, Sang Hyun ; Byun, Jae Ho ; Lee, So Jung ; Kim, So Yeon ; Won, Hyung Jin ; Shin, Yong Moon ; Kim, Pyo-Nyun</creator><creatorcontrib>Byun, Jieun ; Choi, Sang Hyun ; Byun, Jae Ho ; Lee, So Jung ; Kim, So Yeon ; Won, Hyung Jin ; Shin, Yong Moon ; Kim, Pyo-Nyun</creatorcontrib><description>Background and purpose
Imaging-based diagnostic systems play important roles in hepatocellular carcinoma (HCC). We aimed to compare the diagnostic performance of recently updated imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced magnetic resonance imaging (MRI).
Methods
493 nodules (399 HCCs, 24 other malignancies, 70 benign) 1.0–3.0 cm from 400 patients, including 322 male (mean age 59.3 ± 9.4 years) and 78 female (mean age 61.2 ± 9.0 years), at risk for HCC who underwent gadoxetate disodium-enhanced MRI between July 2015 and December 2016 were retrospectively evaluated. Final diagnosis was determined histopathologically or clinically. The sensitivity and specificity in diagnosing HCC of the latest versions of four imaging criteria [Liver Imaging Reporting and Data System (LI-RADS), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), Korean Liver Cancer Association-National Cancer Center (KLCA-NCC)] were compared using generalized estimating equations.
Results
In 331 only pathologically diagnosed nodules, the sensitivities of both the APASL (86.8%) and KLCA-NCC criteria (85.4%) were significantly higher than the sensitivities of the EASL (71.8%) and LR-5 (71.1%) criteria (
p
< 0.001 for each pairwise comparison). However, the specificity of LR-5 was significantly higher than that of APASL (92.2% vs. 70.6%, respectively;
p
= 0.011) but did not differ significantly from the specificities of EASL (84.3%;
p
= 0.634) and KLCA-NCC (78.4%;
p
= 0.107).
Conclusion
Of the four international imaging criteria, LI-RADS and EASL showed high specificity but suboptimal sensitivity for diagnosing HCCs ≤ 3 cm. However, APASL and KLCA-NCC had a higher sensitivity but a lower specificity than LI-RADS and EASL.</description><identifier>ISSN: 1936-0533</identifier><identifier>EISSN: 1936-0541</identifier><identifier>DOI: 10.1007/s12072-020-10040-2</identifier><identifier>PMID: 32314171</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - diagnostic imaging ; Colorectal Surgery ; Contrast Media ; Criteria ; Diagnostic systems ; Female ; Gadolinium DTPA ; Hepatocellular carcinoma ; Hepatology ; Humans ; Liver ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Nodules ; Original Article ; Reproducibility of Results ; Sensitivity and Specificity ; Surgery</subject><ispartof>Hepatology international, 2020-07, Vol.14 (4), p.534-543</ispartof><rights>Asian Pacific Association for the Study of the Liver 2020</rights><rights>Asian Pacific Association for the Study of the Liver 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2127662e974aacc1d613d0586c2f0dd5a77c3ece2024c905a0d56d7f8f78c6c13</citedby><cites>FETCH-LOGICAL-c375t-2127662e974aacc1d613d0586c2f0dd5a77c3ece2024c905a0d56d7f8f78c6c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12072-020-10040-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12072-020-10040-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32314171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byun, Jieun</creatorcontrib><creatorcontrib>Choi, Sang Hyun</creatorcontrib><creatorcontrib>Byun, Jae Ho</creatorcontrib><creatorcontrib>Lee, So Jung</creatorcontrib><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Won, Hyung Jin</creatorcontrib><creatorcontrib>Shin, Yong Moon</creatorcontrib><creatorcontrib>Kim, Pyo-Nyun</creatorcontrib><title>Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI</title><title>Hepatology international</title><addtitle>Hepatol Int</addtitle><addtitle>Hepatol Int</addtitle><description>Background and purpose
Imaging-based diagnostic systems play important roles in hepatocellular carcinoma (HCC). We aimed to compare the diagnostic performance of recently updated imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced magnetic resonance imaging (MRI).
Methods
493 nodules (399 HCCs, 24 other malignancies, 70 benign) 1.0–3.0 cm from 400 patients, including 322 male (mean age 59.3 ± 9.4 years) and 78 female (mean age 61.2 ± 9.0 years), at risk for HCC who underwent gadoxetate disodium-enhanced MRI between July 2015 and December 2016 were retrospectively evaluated. Final diagnosis was determined histopathologically or clinically. The sensitivity and specificity in diagnosing HCC of the latest versions of four imaging criteria [Liver Imaging Reporting and Data System (LI-RADS), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), Korean Liver Cancer Association-National Cancer Center (KLCA-NCC)] were compared using generalized estimating equations.
Results
In 331 only pathologically diagnosed nodules, the sensitivities of both the APASL (86.8%) and KLCA-NCC criteria (85.4%) were significantly higher than the sensitivities of the EASL (71.8%) and LR-5 (71.1%) criteria (
p
< 0.001 for each pairwise comparison). However, the specificity of LR-5 was significantly higher than that of APASL (92.2% vs. 70.6%, respectively;
p
= 0.011) but did not differ significantly from the specificities of EASL (84.3%;
p
= 0.634) and KLCA-NCC (78.4%;
p
= 0.107).
Conclusion
Of the four international imaging criteria, LI-RADS and EASL showed high specificity but suboptimal sensitivity for diagnosing HCCs ≤ 3 cm. However, APASL and KLCA-NCC had a higher sensitivity but a lower specificity than LI-RADS and EASL.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Colorectal Surgery</subject><subject>Contrast Media</subject><subject>Criteria</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nodules</subject><subject>Original Article</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><issn>1936-0533</issn><issn>1936-0541</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9uGyEUh1GVqnbdXqCLCimbbiZ5wACeZTTKPylRpCpdIwrMBMszODAjxbtsc4sucpIeJScprhNHyiIb4Ol9fA_xQ-gbgQMCIA8ToSBpARSKXJdQ0A9oSiomCuAl2dudGZugzyktADgXRHxCE0YZKYkkU7SuQ7fS0afQ49Dg4cZh63XbhzR4g1cuNiF2ujdu0_Wdbn3fYhP94KLXODfxWV2np_uHp4fHvLID-PvHdDjbWm3DnRv0sDGmYP3YFa6_2bgsvvx5_gV9bPQyua_P-wz9Ojm-rs-Ki6vT8_roojBM8qGghEohqKtkqbUxxArCLPC5MLQBa7mW0jBnHAVamgq4BsuFlc28kXMjDGEz9GPrXcVwO7o0qM4n45ZL3bswJkVZxYBVFYeM7r9BF2GMfX6doiUtS8Gh4pmiW8rEkFJ0jVrF_DNxrQioTTBqG4zKwaj_weQZM_T9WT3-7pzdXXlJIgNsC6Tc6lsXX2e_o_0Hx_KbXQ</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Byun, Jieun</creator><creator>Choi, Sang Hyun</creator><creator>Byun, Jae Ho</creator><creator>Lee, So Jung</creator><creator>Kim, So Yeon</creator><creator>Won, Hyung Jin</creator><creator>Shin, Yong Moon</creator><creator>Kim, Pyo-Nyun</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20200701</creationdate><title>Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI</title><author>Byun, Jieun ; Choi, Sang Hyun ; Byun, Jae Ho ; Lee, So Jung ; Kim, So Yeon ; Won, Hyung Jin ; Shin, Yong Moon ; Kim, Pyo-Nyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-2127662e974aacc1d613d0586c2f0dd5a77c3ece2024c905a0d56d7f8f78c6c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Colorectal Surgery</topic><topic>Contrast Media</topic><topic>Criteria</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nodules</topic><topic>Original Article</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byun, Jieun</creatorcontrib><creatorcontrib>Choi, Sang Hyun</creatorcontrib><creatorcontrib>Byun, Jae Ho</creatorcontrib><creatorcontrib>Lee, So Jung</creatorcontrib><creatorcontrib>Kim, So Yeon</creatorcontrib><creatorcontrib>Won, Hyung Jin</creatorcontrib><creatorcontrib>Shin, Yong Moon</creatorcontrib><creatorcontrib>Kim, Pyo-Nyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byun, Jieun</au><au>Choi, Sang Hyun</au><au>Byun, Jae Ho</au><au>Lee, So Jung</au><au>Kim, So Yeon</au><au>Won, Hyung Jin</au><au>Shin, Yong Moon</au><au>Kim, Pyo-Nyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI</atitle><jtitle>Hepatology international</jtitle><stitle>Hepatol Int</stitle><addtitle>Hepatol Int</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>14</volume><issue>4</issue><spage>534</spage><epage>543</epage><pages>534-543</pages><issn>1936-0533</issn><eissn>1936-0541</eissn><abstract>Background and purpose
Imaging-based diagnostic systems play important roles in hepatocellular carcinoma (HCC). We aimed to compare the diagnostic performance of recently updated imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced magnetic resonance imaging (MRI).
Methods
493 nodules (399 HCCs, 24 other malignancies, 70 benign) 1.0–3.0 cm from 400 patients, including 322 male (mean age 59.3 ± 9.4 years) and 78 female (mean age 61.2 ± 9.0 years), at risk for HCC who underwent gadoxetate disodium-enhanced MRI between July 2015 and December 2016 were retrospectively evaluated. Final diagnosis was determined histopathologically or clinically. The sensitivity and specificity in diagnosing HCC of the latest versions of four imaging criteria [Liver Imaging Reporting and Data System (LI-RADS), European Association for the Study of the Liver (EASL), Asian Pacific Association for the Study of the Liver (APASL), Korean Liver Cancer Association-National Cancer Center (KLCA-NCC)] were compared using generalized estimating equations.
Results
In 331 only pathologically diagnosed nodules, the sensitivities of both the APASL (86.8%) and KLCA-NCC criteria (85.4%) were significantly higher than the sensitivities of the EASL (71.8%) and LR-5 (71.1%) criteria (
p
< 0.001 for each pairwise comparison). However, the specificity of LR-5 was significantly higher than that of APASL (92.2% vs. 70.6%, respectively;
p
= 0.011) but did not differ significantly from the specificities of EASL (84.3%;
p
= 0.634) and KLCA-NCC (78.4%;
p
= 0.107).
Conclusion
Of the four international imaging criteria, LI-RADS and EASL showed high specificity but suboptimal sensitivity for diagnosing HCCs ≤ 3 cm. However, APASL and KLCA-NCC had a higher sensitivity but a lower specificity than LI-RADS and EASL.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>32314171</pmid><doi>10.1007/s12072-020-10040-2</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnostic imaging Colorectal Surgery Contrast Media Criteria Diagnostic systems Female Gadolinium DTPA Hepatocellular carcinoma Hepatology Humans Liver Liver cancer Liver Neoplasms - diagnostic imaging Magnetic Resonance Imaging Male Medical diagnosis Medical imaging Medicine Medicine & Public Health Middle Aged Nodules Original Article Reproducibility of Results Sensitivity and Specificity Surgery |
| title | Comparison of the diagnostic performance of imaging criteria for HCCs ≤ 3.0 cm on gadoxetate disodium-enhanced MRI |
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