Tyrosine kinase inhibitors induce alternative spliced BCR‐ABLIns35bp variant via inhibition of RNA polymerase II on genomic BCR‐ABL

To elucidate dynamic changes in native BCR‐ABL and alternatively spliced tyrosine kinase inhibitor (TKI)‐resistant but function‐dead BCR‐ABLIns35bp variant, following commencement or discontinuation of TKI therapy, each transcript was serially quantified in patients with chronic myeloid leukemia (CM...

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Veröffentlicht in:	Cancer science 2020-07, Vol.111 (7), p.2361-2373
Hauptverfasser:	Yuda, Junichiro, Odawara, Jun, Minami, Mariko, Muta, Tsuyoshi, Kohno, Kentaro, Tanimoto, Kazuki, Eto, Tetsuya, Shima, Takahiro, Kikushige, Yoshikane, Kato, Koji, Takenaka, Katsuto, Iwasaki, Hiromi, Minami, Yosuke, Ohkawa, Yasuyuki, Akashi, Koichi, Miyamoto, Toshihiro
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	alternative splicing BCR‐ABL BCR‐ABLIns35bp chronic myeloid leukemia MRD
Online-Zugang:	Volltext
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