Enhanced reactivity of twisted amides inside a molecular cage

When an amide group is distorted from its planar conformation, the conjugation between the nitrogen lone pair and the π * orbital of the carbonyl is disrupted and the reactivity towards nucleophiles is enhanced. Although there are several reports on the synthesis of activated twisted amides, amide a...

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Veröffentlicht in:	Nature chemistry 2020-06, Vol.12 (6), p.574-578
Hauptverfasser:	Takezawa, Hiroki, Shitozawa, Kosuke, Fujita, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	639/638 639/638/403 639/638/541 639/638/911 Activation Amides Analytical Chemistry Biochemistry Cages Carbonyl compounds Carbonyls Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Conformation Conjugation Crystals Distortion Hydrolysis Inorganic Chemistry Nucleophiles Organic Chemistry Physical Chemistry Reactivity Self-assembly Single crystals Twisting X-ray diffraction
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