Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes

Oxidative stress (OS) contributes to Osteoarthritis (OA) pathogenesis and its effects are worsened by the impairment of homeostatic mechanisms such as autophagy in OA chondrocytes. Rescue of an efficient autophagic flux could therefore reduce the bulk of damaged molecules, and at the same time impro...

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Veröffentlicht in:	Free radical biology & medicine 2020-06, Vol.153, p.159-172
Hauptverfasser:	D'Adamo, Stefania, Cetrullo, Silvia, Guidotti, Serena, Silvestri, Ylenia, Minguzzi, Manuela, Santi, Spartaco, Cattini, Luca, Filardo, Giuseppe, Flamigni, Flavio, Borzì, Rosa Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Chondrocytes Osteoarthritis Oxidative stress Spermidine
Online-Zugang:	Volltext
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