Eicosapentaenoic Acid-Enriched Phosphoethanolamine Plasmalogens Alleviated Atherosclerosis by Remodeling Gut Microbiota to Regulate Bile Acid Metabolism in LDLR–/– Mice

Eicosapentaenoic acid (EPA)-enriched phosphoethanolamine plasmalogens (EPA-PlsEtns) might be retained in the intestine rich in gut microbiota for a long time after treatment. It reminded us that EPA-PlsEtns might affect intestinal microbiota composition and its metabolites, which have been identifie...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2020-05, Vol.68 (19), p.5339-5348
Hauptverfasser:	Ding, Lin, Zhang, Ling-Yu, Shi, Hao-Hao, Wang, Cheng-Cheng, Jiang, Xiao-Ming, Xue, Chang-Hu, Yanagita, Teruyoshi, Zhang, Tian-Tian, Wang, Yu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - drug therapy Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - microbiology Bile Acids and Salts - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Eicosapentaenoic Acid - administration & dosage Ethanolamines - administration & dosage Ethanolamines - analysis Gastrointestinal Microbiome - drug effects Humans Male Mice Mice, Knockout Plasmalogens - administration & dosage Plasmalogens - analysis Receptors, LDL - genetics Receptors, LDL - metabolism
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