COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation
We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operati...
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| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2020-08, Vol.144 (8), p.929-932 |
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| container_title | Archives of pathology & laboratory medicine (1976) |
| container_volume | 144 |
| creator | Lagana, Stephen M De Michele, Simona Lee, Michael J Emond, Jean C Griesemer, Adam D Tulin-Silver, Sheryl A Verna, Elizabeth C Martinez, Mercedes Lefkowitch, Jay H |
| description | We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted. |
| doi_str_mv | 10.5858/arpa.2020-0186-SA |
| format | Article |
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The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted.</description><identifier>ISSN: 0003-9985</identifier><identifier>ISSN: 1543-2165</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/arpa.2020-0186-SA</identifier><identifier>PMID: 32302212</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Alanine ; Alanine transaminase ; Alkaline phosphatase ; Apoptosis ; Aspartate aminotransferase ; Balloon treatment ; Biliary atresia ; Biopsy ; Cirrhosis ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 diagnostic tests ; Disease transmission ; Enzymes ; Fever ; Hepatitis ; Histology ; Inflammation ; Liver cirrhosis ; Liver diseases ; Liver transplantation ; Liver transplants ; Mitosis ; Morbidity ; Parenchyma ; Pediatrics ; Phosphatase ; Polymerase chain reaction ; Ribonucleic acid ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; Steatosis ; Tissue donation</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2020-08, Vol.144 (8), p.929-932</ispartof><rights>COPYRIGHT 2020 College of American Pathologists</rights><rights>Copyright College of American Pathologists Aug 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-9889d4670e230c7d065a15fecb19828ad172390910c4146a105b578973f04d413</citedby><cites>FETCH-LOGICAL-c508t-9889d4670e230c7d065a15fecb19828ad172390910c4146a105b578973f04d413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32302212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lagana, Stephen M</creatorcontrib><creatorcontrib>De Michele, Simona</creatorcontrib><creatorcontrib>Lee, Michael J</creatorcontrib><creatorcontrib>Emond, Jean C</creatorcontrib><creatorcontrib>Griesemer, Adam D</creatorcontrib><creatorcontrib>Tulin-Silver, Sheryl A</creatorcontrib><creatorcontrib>Verna, Elizabeth C</creatorcontrib><creatorcontrib>Martinez, Mercedes</creatorcontrib><creatorcontrib>Lefkowitch, Jay H</creatorcontrib><title>COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Apoptosis</subject><subject>Aspartate aminotransferase</subject><subject>Balloon treatment</subject><subject>Biliary atresia</subject><subject>Biopsy</subject><subject>Cirrhosis</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 diagnostic tests</subject><subject>Disease transmission</subject><subject>Enzymes</subject><subject>Fever</subject><subject>Hepatitis</subject><subject>Histology</subject><subject>Inflammation</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver transplantation</subject><subject>Liver transplants</subject><subject>Mitosis</subject><subject>Morbidity</subject><subject>Parenchyma</subject><subject>Pediatrics</subject><subject>Phosphatase</subject><subject>Polymerase chain reaction</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Steatosis</subject><subject>Tissue 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Hepatitis Complicating Recent Living Donor Liver Transplantation</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>144</volume><issue>8</issue><spage>929</spage><epage>932</epage><pages>929-932</pages><issn>0003-9985</issn><issn>1543-2165</issn><eissn>1543-2165</eissn><abstract>We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>32302212</pmid><doi>10.5858/arpa.2020-0186-SA</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9985 |
| ispartof | Archives of pathology & laboratory medicine (1976), 2020-08, Vol.144 (8), p.929-932 |
| issn | 0003-9985 1543-2165 1543-2165 |
| language | eng |
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| source | Allen Press Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alanine Alanine transaminase Alkaline phosphatase Apoptosis Aspartate aminotransferase Balloon treatment Biliary atresia Biopsy Cirrhosis Coronaviridae Coronaviruses COVID-19 COVID-19 diagnostic tests Disease transmission Enzymes Fever Hepatitis Histology Inflammation Liver cirrhosis Liver diseases Liver transplantation Liver transplants Mitosis Morbidity Parenchyma Pediatrics Phosphatase Polymerase chain reaction Ribonucleic acid RNA Severe acute respiratory syndrome coronavirus 2 Steatosis Tissue donation |
| title | COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation |
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