Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images
In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated. In 57 patients operated for hyperparathyroidism, the parathyroid gl...
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| Veröffentlicht in: | Annals of diagnostic pathology 2020-06, Vol.46, p.151492-151492, Article 151492 |
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| container_title | Annals of diagnostic pathology |
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| creator | Yazgan, Aylin Kılıç Topaloğlu, Oya Çuhacı, Fatma Neslihan Özdemir, Didem Alkan, Afra Kılıç, Mehmet Ersoy, Reyhan Çakır, Bekir |
| description | In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.
In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. The lesion slides were scanned. The WSI was rendered digital. The histopathological slide images scanned with USG images were matched. With the İmage J program, the areas of cell types and morphological changes were measured.
In parathyroid neoplasms, hypoechoic areas were found to be matched with 21% [55.3%] chief cell, 2 [5.0%] oncocytic cell and 8%[20.0%] cystic morphology. Of the 57 patients, 26 [45.61%] had a cystic area. It was seen that hyperechogenic areas match more connective tissue areas than chef cell [p |
| doi_str_mv | 10.1016/j.anndiagpath.2020.151492 |
| format | Article |
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In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. The lesion slides were scanned. The WSI was rendered digital. The histopathological slide images scanned with USG images were matched. With the İmage J program, the areas of cell types and morphological changes were measured.
In parathyroid neoplasms, hypoechoic areas were found to be matched with 21% [55.3%] chief cell, 2 [5.0%] oncocytic cell and 8%[20.0%] cystic morphology. Of the 57 patients, 26 [45.61%] had a cystic area. It was seen that hyperechogenic areas match more connective tissue areas than chef cell [p < 0.05]. There was less clear cell in hyperechogenic areas than iso-hyperechogenic areas [p < 0.05]. The ratio of fat tissue echogenicity was lower in hypoechoic areas than hyperechoic [p < 0.05]. There was a positive correlation between PTH and the entire tissue area [r = 0.377, p = 0.004]. A positive directional moderate linear relationship was found between blood calcium level and parathyroid adenoma [rho = 0.530, p = 0.009] and percentage [rho = 0.416, p = 0.048]. When atypical adenomas and adenoma cases were compared, no significant difference was found between the cystic and chief cell areas [p > 0.05].
The hypoechogenicity seen in USG was observed to be compatible with chief cell, hyperechogenic areas in USG were compatible with connective tissue and fat tissue. As the cystic area increased, blood calcium levels were higher in adenomas. We think that the results of this study will be guiding to evaluate the reflections of the detailed morphometric studies.
•The hyperechogen areas seen in USG was observed to be compatible with connective and fat tissue.•Macro and micro cystic changes are common in parathyroid adenomas.•As the cystic area increased, blood calcium levels were higher in adenomas.•The relationship between the role of calcium in the cell and cystic formation is open to research.</description><identifier>ISSN: 1092-9134</identifier><identifier>EISSN: 1532-8198</identifier><identifier>DOI: 10.1016/j.anndiagpath.2020.151492</identifier><identifier>PMID: 32302921</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>cystic ; echogenicity ; Parathyroid ; parathyroid adenoma ; ultrasound ; whole slide imaging</subject><ispartof>Annals of diagnostic pathology, 2020-06, Vol.46, p.151492-151492, Article 151492</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-cfe35717b404160716bdbc46637f4c43240310efdccba3ee1c6a1ad6fc736e783</citedby><cites>FETCH-LOGICAL-c377t-cfe35717b404160716bdbc46637f4c43240310efdccba3ee1c6a1ad6fc736e783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anndiagpath.2020.151492$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32302921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yazgan, Aylin Kılıç</creatorcontrib><creatorcontrib>Topaloğlu, Oya</creatorcontrib><creatorcontrib>Çuhacı, Fatma Neslihan</creatorcontrib><creatorcontrib>Özdemir, Didem</creatorcontrib><creatorcontrib>Alkan, Afra</creatorcontrib><creatorcontrib>Kılıç, Mehmet</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Çakır, Bekir</creatorcontrib><title>Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images</title><title>Annals of diagnostic pathology</title><addtitle>Ann Diagn Pathol</addtitle><description>In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.
In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. The lesion slides were scanned. The WSI was rendered digital. The histopathological slide images scanned with USG images were matched. With the İmage J program, the areas of cell types and morphological changes were measured.
In parathyroid neoplasms, hypoechoic areas were found to be matched with 21% [55.3%] chief cell, 2 [5.0%] oncocytic cell and 8%[20.0%] cystic morphology. Of the 57 patients, 26 [45.61%] had a cystic area. It was seen that hyperechogenic areas match more connective tissue areas than chef cell [p < 0.05]. There was less clear cell in hyperechogenic areas than iso-hyperechogenic areas [p < 0.05]. The ratio of fat tissue echogenicity was lower in hypoechoic areas than hyperechoic [p < 0.05]. There was a positive correlation between PTH and the entire tissue area [r = 0.377, p = 0.004]. A positive directional moderate linear relationship was found between blood calcium level and parathyroid adenoma [rho = 0.530, p = 0.009] and percentage [rho = 0.416, p = 0.048]. When atypical adenomas and adenoma cases were compared, no significant difference was found between the cystic and chief cell areas [p > 0.05].
The hypoechogenicity seen in USG was observed to be compatible with chief cell, hyperechogenic areas in USG were compatible with connective tissue and fat tissue. As the cystic area increased, blood calcium levels were higher in adenomas. We think that the results of this study will be guiding to evaluate the reflections of the detailed morphometric studies.
•The hyperechogen areas seen in USG was observed to be compatible with connective and fat tissue.•Macro and micro cystic changes are common in parathyroid adenomas.•As the cystic area increased, blood calcium levels were higher in adenomas.•The relationship between the role of calcium in the cell and cystic formation is open to research.</description><subject>cystic</subject><subject>echogenicity</subject><subject>Parathyroid</subject><subject>parathyroid adenoma</subject><subject>ultrasound</subject><subject>whole slide imaging</subject><issn>1092-9134</issn><issn>1532-8198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u1DAURi0EoqXwCsjdscnga3viybIatYBUxAbWlmPfpB5l4tQ3aTVvj0czRV2y8ifr3L_D2DWIFQiov-5WbhxDdP3k5oeVFLL8r0E38g27hLWS1QaazduSRSOrBpS-YB-IdkIA6LV5zy6UVEI2Ei5Z-ummKY49Tx2fXC79DjnFwEdM0-BoT7x1hIGnkfcZD5y8G5Avw5wdpWUMPO5dj8RdiQ-R5nRcKQ2pjwXkzyUipyEGPIMf2bvODYSfzu8V-3N3-3v7vbr_9e3H9ua-8sqYufIdqrUB02qhoRYG6ja0Xte1Mp32WkktFAjsgvetU4jgawcu1J03qkazUVfsy6nvlNPjgjTbfSSPw-DKZQtZqZriCMRGF7Q5oT4nooydnXJZNh8sCHv0bXf2lW979G1Pvkvt5_OYpd1j-Ff5IrgA2xOA5diniNmSjzh6DDGjn21I8T_G_AVJ1pmO</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Yazgan, Aylin Kılıç</creator><creator>Topaloğlu, Oya</creator><creator>Çuhacı, Fatma Neslihan</creator><creator>Özdemir, Didem</creator><creator>Alkan, Afra</creator><creator>Kılıç, Mehmet</creator><creator>Ersoy, Reyhan</creator><creator>Çakır, Bekir</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200601</creationdate><title>Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images</title><author>Yazgan, Aylin Kılıç ; Topaloğlu, Oya ; Çuhacı, Fatma Neslihan ; Özdemir, Didem ; Alkan, Afra ; Kılıç, Mehmet ; Ersoy, Reyhan ; Çakır, Bekir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-cfe35717b404160716bdbc46637f4c43240310efdccba3ee1c6a1ad6fc736e783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cystic</topic><topic>echogenicity</topic><topic>Parathyroid</topic><topic>parathyroid adenoma</topic><topic>ultrasound</topic><topic>whole slide imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yazgan, Aylin Kılıç</creatorcontrib><creatorcontrib>Topaloğlu, Oya</creatorcontrib><creatorcontrib>Çuhacı, Fatma Neslihan</creatorcontrib><creatorcontrib>Özdemir, Didem</creatorcontrib><creatorcontrib>Alkan, Afra</creatorcontrib><creatorcontrib>Kılıç, Mehmet</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Çakır, Bekir</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yazgan, Aylin Kılıç</au><au>Topaloğlu, Oya</au><au>Çuhacı, Fatma Neslihan</au><au>Özdemir, Didem</au><au>Alkan, Afra</au><au>Kılıç, Mehmet</au><au>Ersoy, Reyhan</au><au>Çakır, Bekir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images</atitle><jtitle>Annals of diagnostic pathology</jtitle><addtitle>Ann Diagn Pathol</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>46</volume><spage>151492</spage><epage>151492</epage><pages>151492-151492</pages><artnum>151492</artnum><issn>1092-9134</issn><eissn>1532-8198</eissn><abstract>In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.
In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. The lesion slides were scanned. The WSI was rendered digital. The histopathological slide images scanned with USG images were matched. With the İmage J program, the areas of cell types and morphological changes were measured.
In parathyroid neoplasms, hypoechoic areas were found to be matched with 21% [55.3%] chief cell, 2 [5.0%] oncocytic cell and 8%[20.0%] cystic morphology. Of the 57 patients, 26 [45.61%] had a cystic area. It was seen that hyperechogenic areas match more connective tissue areas than chef cell [p < 0.05]. There was less clear cell in hyperechogenic areas than iso-hyperechogenic areas [p < 0.05]. The ratio of fat tissue echogenicity was lower in hypoechoic areas than hyperechoic [p < 0.05]. There was a positive correlation between PTH and the entire tissue area [r = 0.377, p = 0.004]. A positive directional moderate linear relationship was found between blood calcium level and parathyroid adenoma [rho = 0.530, p = 0.009] and percentage [rho = 0.416, p = 0.048]. When atypical adenomas and adenoma cases were compared, no significant difference was found between the cystic and chief cell areas [p > 0.05].
The hypoechogenicity seen in USG was observed to be compatible with chief cell, hyperechogenic areas in USG were compatible with connective tissue and fat tissue. As the cystic area increased, blood calcium levels were higher in adenomas. We think that the results of this study will be guiding to evaluate the reflections of the detailed morphometric studies.
•The hyperechogen areas seen in USG was observed to be compatible with connective and fat tissue.•Macro and micro cystic changes are common in parathyroid adenomas.•As the cystic area increased, blood calcium levels were higher in adenomas.•The relationship between the role of calcium in the cell and cystic formation is open to research.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32302921</pmid><doi>10.1016/j.anndiagpath.2020.151492</doi><tpages>1</tpages></addata></record> |
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| subjects | cystic echogenicity Parathyroid parathyroid adenoma ultrasound whole slide imaging |
| title | Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images |
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