Role of pyroptosis in liver diseases
•Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can m...
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| Veröffentlicht in: | International immunopharmacology 2020-07, Vol.84, p.106489-106489, Article 106489 |
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| container_title | International immunopharmacology |
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| creator | Al Mamun, Abdullah Wu, Yanqing Jia, Chang Munir, Fahad Sathy, Kasfia Jahan Sarker, Tamanna Monalisa, Ilma Zhou, Kailiang Xiao, Jian |
| description | •Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can markedly inhibit pyroptosis, which can prevent the liver diseases.•So, Targeting pyroptosis can be a new potential therapeutic target for the treatment of liver diseases in the near future.
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future. |
| doi_str_mv | 10.1016/j.intimp.2020.106489 |
| format | Article |
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Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.106489</identifier><identifier>PMID: 32304992</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Apoptosis ; Caspase-1 ; Caspase-1, liver diseases ; Caspase-4 ; Caspases - metabolism ; Cell death ; Cytokines ; Humans ; Immune system ; Inflammasomes - metabolism ; Inflammation ; Intracellular Signaling Peptides and Proteins - metabolism ; Intracellular signalling ; Liver ; Liver diseases ; Liver Diseases - drug therapy ; Liver Diseases - etiology ; Liver Diseases - metabolism ; Liver Diseases - pathology ; Lysis ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; NLRP3 ; Non-alcoholic fatty liver disease ; Phosphate-Binding Proteins - metabolism ; Pore formation ; Pyroptosis ; Pyroptosis - physiology</subject><ispartof>International immunopharmacology, 2020-07, Vol.84, p.106489-106489, Article 106489</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-8a1385ab8f247c714779971e8f1b6d6edf755d0346ca450c5388e3a339718a883</citedby><cites>FETCH-LOGICAL-c390t-8a1385ab8f247c714779971e8f1b6d6edf755d0346ca450c5388e3a339718a883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.106489$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32304992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Mamun, Abdullah</creatorcontrib><creatorcontrib>Wu, Yanqing</creatorcontrib><creatorcontrib>Jia, Chang</creatorcontrib><creatorcontrib>Munir, Fahad</creatorcontrib><creatorcontrib>Sathy, Kasfia Jahan</creatorcontrib><creatorcontrib>Sarker, Tamanna</creatorcontrib><creatorcontrib>Monalisa, Ilma</creatorcontrib><creatorcontrib>Zhou, Kailiang</creatorcontrib><creatorcontrib>Xiao, Jian</creatorcontrib><title>Role of pyroptosis in liver diseases</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>•Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can markedly inhibit pyroptosis, which can prevent the liver diseases.•So, Targeting pyroptosis can be a new potential therapeutic target for the treatment of liver diseases in the near future.
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Caspase-1</subject><subject>Caspase-1, liver diseases</subject><subject>Caspase-4</subject><subject>Caspases - metabolism</subject><subject>Cell death</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Immune system</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Intracellular signalling</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver Diseases - drug therapy</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - metabolism</subject><subject>Liver Diseases - pathology</subject><subject>Lysis</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>NLRP3</subject><subject>Non-alcoholic fatty liver disease</subject><subject>Phosphate-Binding Proteins - metabolism</subject><subject>Pore formation</subject><subject>Pyroptosis</subject><subject>Pyroptosis - physiology</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0QKevDSNWnSJrkIsvgFC4LoOWTTKaS0TU3ahf33ZunqwYOnGYZn3hkehC4JXhJMirt6abvBtv0yw9l-VDAhj9CcCC5SwnF-HPu84GnOCzlDZyHUGMc5I6doRjOKmZTZHN28uwYSVyX9zrt-cMGGxHZJY7fgk9IG0AHCOTqpdBPg4lAX6PPp8WP1kq7fnl9XD-vUUImHVGhCRa43osoYN5wwzqXkBERFNkVZQFnxPC8xZYXRLMcmp0IA1ZRGSGgh6ALdTrm9d18jhEG1NhhoGt2BG4PKqCSSxxAa0es_aO1G38XvVMZYfEdgyiPFJsp4F4KHSvXettrvFMFqb1HVarKo9hbVZDGuXR3Cx00L5e_Sj7YI3E8ARBtbC14FY6EzUFoPZlCls_9f-AZdB4G9</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Al Mamun, Abdullah</creator><creator>Wu, Yanqing</creator><creator>Jia, Chang</creator><creator>Munir, Fahad</creator><creator>Sathy, Kasfia Jahan</creator><creator>Sarker, Tamanna</creator><creator>Monalisa, Ilma</creator><creator>Zhou, Kailiang</creator><creator>Xiao, Jian</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>Role of pyroptosis in liver diseases</title><author>Al Mamun, Abdullah ; Wu, Yanqing ; Jia, Chang ; Munir, Fahad ; Sathy, Kasfia Jahan ; Sarker, Tamanna ; Monalisa, Ilma ; Zhou, Kailiang ; Xiao, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-8a1385ab8f247c714779971e8f1b6d6edf755d0346ca450c5388e3a339718a883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Caspase-1</topic><topic>Caspase-1, liver diseases</topic><topic>Caspase-4</topic><topic>Caspases - metabolism</topic><topic>Cell death</topic><topic>Cytokines</topic><topic>Humans</topic><topic>Immune system</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Intracellular signalling</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver Diseases - drug therapy</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - metabolism</topic><topic>Liver Diseases - pathology</topic><topic>Lysis</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</topic><topic>NLRP3</topic><topic>Non-alcoholic fatty liver disease</topic><topic>Phosphate-Binding Proteins - metabolism</topic><topic>Pore formation</topic><topic>Pyroptosis</topic><topic>Pyroptosis - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Mamun, Abdullah</creatorcontrib><creatorcontrib>Wu, Yanqing</creatorcontrib><creatorcontrib>Jia, Chang</creatorcontrib><creatorcontrib>Munir, Fahad</creatorcontrib><creatorcontrib>Sathy, Kasfia Jahan</creatorcontrib><creatorcontrib>Sarker, Tamanna</creatorcontrib><creatorcontrib>Monalisa, Ilma</creatorcontrib><creatorcontrib>Zhou, Kailiang</creatorcontrib><creatorcontrib>Xiao, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Mamun, Abdullah</au><au>Wu, Yanqing</au><au>Jia, Chang</au><au>Munir, Fahad</au><au>Sathy, Kasfia Jahan</au><au>Sarker, Tamanna</au><au>Monalisa, Ilma</au><au>Zhou, Kailiang</au><au>Xiao, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of pyroptosis in liver diseases</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>84</volume><spage>106489</spage><epage>106489</epage><pages>106489-106489</pages><artnum>106489</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•Pyroptosis is known as programmed cell death.•There are two types of signaling pathways, such as caspase-1, and caspase-4/5/11 mediated pathways, involved in pyroptosis.•Pyroptosis plays crucial roles in the pathogenesis and progression of various liver diseases.•NLRP3 inflammasome inhibitors can markedly inhibit pyroptosis, which can prevent the liver diseases.•So, Targeting pyroptosis can be a new potential therapeutic target for the treatment of liver diseases in the near future.
Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is exceptional from other types of cell death programs. Particularly, pyroptosis is characterized by Gasdermin family-mediated pore formation and subsequently cellular lysis, also release of several pro-inflammatory intracellular cytokines. In terms of mechanism, there are two signaling pathways involved in pyroptosis, including caspase-1, and caspase-4/5/11 mediated pathways. However, pyroptosis plays important roles in immune defense mechanisms. Recent studies have demonstrated that pyroptosis plays significant roles in the development of liver diseases. In our review, we have focused on the role of pyroptosis based on the molecular and pathophysiological mechanisms in the development of liver diseases. We have also highlighted targeting of pyroptosis for the therapeutic implications in liver diseases in the near future.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32304992</pmid><doi>10.1016/j.intimp.2020.106489</doi><tpages>1</tpages></addata></record> |
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| subjects | Animals Apoptosis Caspase-1 Caspase-1, liver diseases Caspase-4 Caspases - metabolism Cell death Cytokines Humans Immune system Inflammasomes - metabolism Inflammation Intracellular Signaling Peptides and Proteins - metabolism Intracellular signalling Liver Liver diseases Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - metabolism Liver Diseases - pathology Lysis NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Non-alcoholic fatty liver disease Phosphate-Binding Proteins - metabolism Pore formation Pyroptosis Pyroptosis - physiology |
| title | Role of pyroptosis in liver diseases |
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