High Estrogen Level Modifies Postoperative Hyperalgesia via GPR30 and MMP-9 in Dorsal Root Ganglia Neurons

The cycling of sex hormones is one of the factors affecting pain in females, and the mechanisms are not fully understood. G-protein coupled estrogen receptor 30 (GPR30) is the estrogen receptor known to be involved in mechanical hyperalgesia. Studies have demonstrated that matrix metalloproteinase-9...

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Veröffentlicht in:	Neurochemical research 2020-07, Vol.45 (7), p.1661-1673
Hauptverfasser:	Jiang, Ming, Liu, Yue, Wu, Hao, Ma, Zhengliang, Gu, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Benzodioxoles - pharmacology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Critical components Cysteine Dorsal root ganglia Estrogens Estrogens - metabolism Female Ganglia Ganglia, Spinal - metabolism Gelatinase B Hormone replacement therapy Hormones Hyperalgesia Hyperalgesia - etiology Hyperalgesia - metabolism Hyperalgesia - prevention & control Hypersensitivity IL-1β Inflammation Injection Matrix metalloproteinase Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Metalloproteinase Neurochemistry Neurology Neurons Neurosciences Original Paper Ovariectomy Ovariectomy - adverse effects Oxidation Pain Pain perception Pain, Postoperative - etiology Pain, Postoperative - metabolism Pain, Postoperative - prevention & control Quinolines - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - metabolism Sex hormones
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