High-Density Lipoproteins and Acute Kidney Injury
High-density lipoprotein (HDL) particles, best known for their anti-atherosclerotic effects, also may play a beneficial role during acute renal stress. HDL from healthy human beings also shows anti-inflammatory and anti-oxidant capacities, promotes endothelial function and repair, and serves as a sy...
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| Veröffentlicht in: | Seminars in nephrology 2020-03, Vol.40 (2), p.232-242 |
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| creator | Smith, Loren E. |
| description | High-density lipoprotein (HDL) particles, best known for their anti-atherosclerotic effects, also may play a beneficial role during acute renal stress. HDL from healthy human beings also shows anti-inflammatory and anti-oxidant capacities, promotes endothelial function and repair, and serves as a systemic signaling mechanism facilitating rapid interorgan communication during times of physiologic stress. Higher concentrations of HDL are associated with less acute kidney injury after sepsis, cardiac and vascular surgery, and contrast-exposure during percutaneous coronary interventions. A better understanding of the interplay between HDL and the kidney both under homeostatic conditions and under acute physiologic stress could lead to the identification of novel risk factors and therapeutic targets for acute kidney injury prevention and treatment in the future. |
| doi_str_mv | 10.1016/j.semnephrol.2020.01.013 |
| format | Article |
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A better understanding of the interplay between HDL and the kidney both under homeostatic conditions and under acute physiologic stress could lead to the identification of novel risk factors and therapeutic targets for acute kidney injury prevention and treatment in the future.</description><identifier>ISSN: 0270-9295</identifier><identifier>EISSN: 1558-4488</identifier><identifier>DOI: 10.1016/j.semnephrol.2020.01.013</identifier><identifier>PMID: 32303285</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>acute kidney injury ; Acute Kidney Injury - etiology ; Acute Kidney Injury - metabolism ; Animals ; Cardiovascular Surgical Procedures ; Contrast Media - adverse effects ; contrast-induced AKI ; High-density lipoproteins ; Humans ; Ischemia - complications ; Ischemia - metabolism ; Kidney Tubules, Proximal - metabolism ; lipoproteins ; Lipoproteins, HDL - metabolism ; postoperative AKI ; Postoperative Complications - metabolism ; sepsis ; Sepsis - complications ; Sepsis - metabolism ; Signal Transduction ; Stress, Physiological</subject><ispartof>Seminars in nephrology, 2020-03, Vol.40 (2), p.232-242</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. 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A better understanding of the interplay between HDL and the kidney both under homeostatic conditions and under acute physiologic stress could lead to the identification of novel risk factors and therapeutic targets for acute kidney injury prevention and treatment in the future.</description><subject>acute kidney injury</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Animals</subject><subject>Cardiovascular Surgical Procedures</subject><subject>Contrast Media - adverse effects</subject><subject>contrast-induced AKI</subject><subject>High-density lipoproteins</subject><subject>Humans</subject><subject>Ischemia - complications</subject><subject>Ischemia - metabolism</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>lipoproteins</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>postoperative AKI</subject><subject>Postoperative Complications - metabolism</subject><subject>sepsis</subject><subject>Sepsis - complications</subject><subject>Sepsis - metabolism</subject><subject>Signal Transduction</subject><subject>Stress, Physiological</subject><issn>0270-9295</issn><issn>1558-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EoqXwF1COXBL8SuIcS3m0ohIXOFuOs6aOEqfYCVL-PanK44g00l5mdnY_hCKCE4JJdlsnAVoH-53vmoRiihNMJrETNCdpKmLOhThFc0xzHBe0SGfoIoQaY0pySs7RjFGGGRXpHJG1fd_F9-CC7cdoa_fd3nc9WBci5apoqYceomdbORijjasHP16iM6OaAFffc4HeHh9eV-t4-_K0WS23sWY57-NKKSYMY7oUPGVZSbOSU6ENpmkBRgPPQBiCMefUKIC0FEIobTLOaFnRPGULdHPcOx30MUDoZWuDhqZRDrohSMoKUuQZKw5WcbRq34Xgwci9t63yoyRYHoDJWv4BkwdgEpNJbIpef7cMZQvVb_CH0GS4Oxpg-vXTgpdBW3AaKutB97Lq7P8tX_TdgOc</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Smith, Loren E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202003</creationdate><title>High-Density Lipoproteins and Acute Kidney Injury</title><author>Smith, Loren E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-daa38f33cb84536b26b428cf0259efce46e8f100442faee5b888acf6432bd2753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acute kidney injury</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - metabolism</topic><topic>Animals</topic><topic>Cardiovascular Surgical Procedures</topic><topic>Contrast Media - adverse effects</topic><topic>contrast-induced AKI</topic><topic>High-density lipoproteins</topic><topic>Humans</topic><topic>Ischemia - complications</topic><topic>Ischemia - metabolism</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>lipoproteins</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>postoperative AKI</topic><topic>Postoperative Complications - metabolism</topic><topic>sepsis</topic><topic>Sepsis - complications</topic><topic>Sepsis - metabolism</topic><topic>Signal Transduction</topic><topic>Stress, Physiological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Loren E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Loren E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Density Lipoproteins and Acute Kidney Injury</atitle><jtitle>Seminars in nephrology</jtitle><addtitle>Semin Nephrol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>40</volume><issue>2</issue><spage>232</spage><epage>242</epage><pages>232-242</pages><issn>0270-9295</issn><eissn>1558-4488</eissn><abstract>High-density lipoprotein (HDL) particles, best known for their anti-atherosclerotic effects, also may play a beneficial role during acute renal stress. HDL from healthy human beings also shows anti-inflammatory and anti-oxidant capacities, promotes endothelial function and repair, and serves as a systemic signaling mechanism facilitating rapid interorgan communication during times of physiologic stress. Higher concentrations of HDL are associated with less acute kidney injury after sepsis, cardiac and vascular surgery, and contrast-exposure during percutaneous coronary interventions. A better understanding of the interplay between HDL and the kidney both under homeostatic conditions and under acute physiologic stress could lead to the identification of novel risk factors and therapeutic targets for acute kidney injury prevention and treatment in the future.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32303285</pmid><doi>10.1016/j.semnephrol.2020.01.013</doi><tpages>11</tpages></addata></record> |
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| ispartof | Seminars in nephrology, 2020-03, Vol.40 (2), p.232-242 |
| issn | 0270-9295 1558-4488 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | acute kidney injury Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Animals Cardiovascular Surgical Procedures Contrast Media - adverse effects contrast-induced AKI High-density lipoproteins Humans Ischemia - complications Ischemia - metabolism Kidney Tubules, Proximal - metabolism lipoproteins Lipoproteins, HDL - metabolism postoperative AKI Postoperative Complications - metabolism sepsis Sepsis - complications Sepsis - metabolism Signal Transduction Stress, Physiological |
| title | High-Density Lipoproteins and Acute Kidney Injury |
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