18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra

18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra

To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine. The study population comprised 55 patients (mean age, 51.42 years; median age 52 years) wit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical radiology 2020-08, Vol.75 (8), p.643.e1-643.e10
Hauptverfasser: Usmani, S., Ahmed, N., Marafi, F., al kandari, F., Gnanasegaran, G., Van den Wyngaert, T.
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 643.e10
container_issue 8
container_start_page 643.e1
container_title Clinical radiology
container_volume 75
creator Usmani, S.
Ahmed, N.
Marafi, F.
al kandari, F.
Gnanasegaran, G.
Van den Wyngaert, T.
description To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine. The study population comprised 55 patients (mean age, 51.42 years; median age 52 years) with LSTV. All patients underwent integrated positron-emission tomography (PET)/computed tomography (CT) by injecting 0.06 mCi/kg of 18F-NaF. A three-point grading system was used to evaluate 18F-NaF uptake (grade 0, no uptake; grade 1, mild uptake; and grade 2, marked increase uptake. In total, 55 cases of LSTV (34 symptomatic and 21 asymptomatic) were included. Asymptomatic patients had no uptake in the majority of cases, i.e., grade 0 (n=18) and grade 1 (n=3), whereas symptomatic patients demonstrated focal increase tracer uptake of grade 2 (n=24), grade 1 (n=4), and grade 0 (n=6). There is a strong linear trend between the intensity of 18F-NaF uptake and presence of symptoms (p
doi_str_mv 10.1016/j.crad.2020.03.023
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2391974190</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009926020301240</els_id><sourcerecordid>2391974190</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1780-2211abe234b2feae082892669bcbdfb599ef69c9ecb2117a70d3be9b8f1396543</originalsourceid><addsrcrecordid>eNp9kEFLxDAQhYMouK7-AU89emmdJN22AS-y7Kqw4B4qeAtJOoUsbbMm7cL-e1PWs6fhwXszbz5CHilkFGjxfMiMV03GgEEGPAPGr8iC8mKVMia-r8kCAEQqWAG35C6Ewyxzli_InlbbNLjGTn3SdpPztsFEuwGT_aZO13VihySc--PoejVak3RTr11Q8VqXjF4NwY7WDVGc0I-ovbonN63qAj78zSX52m7q9Xu6-3z7WL_uUkPLCmItSpVGxnPNWlQIFativUJoo5tWr4TAthBGoNHRWaoSGq5R6KqlXBSrnC_J02Xv0bufCcMoexsMdp0a0E1BMi6oKHMqIFrZxWq8C8FjK4_e9sqfJQU545MHOeOTMz4JXEZ8MfRyCWF84mTRy2AsDgYb69GMsnH2v_gv-5Z45A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2391974190</pqid></control><display><type>article</type><title>18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra</title><source>Elsevier ScienceDirect Journals</source><creator>Usmani, S. ; Ahmed, N. ; Marafi, F. ; al kandari, F. ; Gnanasegaran, G. ; Van den Wyngaert, T.</creator><creatorcontrib>Usmani, S. ; Ahmed, N. ; Marafi, F. ; al kandari, F. ; Gnanasegaran, G. ; Van den Wyngaert, T.</creatorcontrib><description>To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine. The study population comprised 55 patients (mean age, 51.42 years; median age 52 years) with LSTV. All patients underwent integrated positron-emission tomography (PET)/computed tomography (CT) by injecting 0.06 mCi/kg of 18F-NaF. A three-point grading system was used to evaluate 18F-NaF uptake (grade 0, no uptake; grade 1, mild uptake; and grade 2, marked increase uptake. In total, 55 cases of LSTV (34 symptomatic and 21 asymptomatic) were included. Asymptomatic patients had no uptake in the majority of cases, i.e., grade 0 (n=18) and grade 1 (n=3), whereas symptomatic patients demonstrated focal increase tracer uptake of grade 2 (n=24), grade 1 (n=4), and grade 0 (n=6). There is a strong linear trend between the intensity of 18F-NaF uptake and presence of symptoms (p&lt;0.0001). The sensitivity and specificity of 18F-NaF uptake at LSTV as a cause of pain were 82% (95% confidence interval [CI]: 65–93%) and 86% (95% CI: 64–97%). The positive and negative predictive values were 90% (95% CI: 74–98%) and 75% (95% CI: 53–90%). 18F-NaF PET/CT can be useful in evaluating back pain and 18F-NaF may be used as an adjunctive biological maker for assessing LSTV as a potential cause of pain. •LSTV is an established cause of low back pain especially in young patients.•18F-NaF PET-CT is a sensitive tool for detecting areas of abnormal bone turnover.•18F-NaF provide molecular knowledge of biomechanical alterations caused by LSTVs.•Strong linear trend between intensity of 18F-NaF uptake and presence of symptoms.•The grade of 18F-NaF uptake is a possible biological marker for symptomatic LSTV.</description><identifier>ISSN: 0009-9260</identifier><identifier>EISSN: 1365-229X</identifier><identifier>DOI: 10.1016/j.crad.2020.03.023</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><ispartof>Clinical radiology, 2020-08, Vol.75 (8), p.643.e1-643.e10</ispartof><rights>2020 The Royal College of Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1780-2211abe234b2feae082892669bcbdfb599ef69c9ecb2117a70d3be9b8f1396543</citedby><cites>FETCH-LOGICAL-c1780-2211abe234b2feae082892669bcbdfb599ef69c9ecb2117a70d3be9b8f1396543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.crad.2020.03.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Usmani, S.</creatorcontrib><creatorcontrib>Ahmed, N.</creatorcontrib><creatorcontrib>Marafi, F.</creatorcontrib><creatorcontrib>al kandari, F.</creatorcontrib><creatorcontrib>Gnanasegaran, G.</creatorcontrib><creatorcontrib>Van den Wyngaert, T.</creatorcontrib><title>18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra</title><title>Clinical radiology</title><description>To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine. The study population comprised 55 patients (mean age, 51.42 years; median age 52 years) with LSTV. All patients underwent integrated positron-emission tomography (PET)/computed tomography (CT) by injecting 0.06 mCi/kg of 18F-NaF. A three-point grading system was used to evaluate 18F-NaF uptake (grade 0, no uptake; grade 1, mild uptake; and grade 2, marked increase uptake. In total, 55 cases of LSTV (34 symptomatic and 21 asymptomatic) were included. Asymptomatic patients had no uptake in the majority of cases, i.e., grade 0 (n=18) and grade 1 (n=3), whereas symptomatic patients demonstrated focal increase tracer uptake of grade 2 (n=24), grade 1 (n=4), and grade 0 (n=6). There is a strong linear trend between the intensity of 18F-NaF uptake and presence of symptoms (p&lt;0.0001). The sensitivity and specificity of 18F-NaF uptake at LSTV as a cause of pain were 82% (95% confidence interval [CI]: 65–93%) and 86% (95% CI: 64–97%). The positive and negative predictive values were 90% (95% CI: 74–98%) and 75% (95% CI: 53–90%). 18F-NaF PET/CT can be useful in evaluating back pain and 18F-NaF may be used as an adjunctive biological maker for assessing LSTV as a potential cause of pain. •LSTV is an established cause of low back pain especially in young patients.•18F-NaF PET-CT is a sensitive tool for detecting areas of abnormal bone turnover.•18F-NaF provide molecular knowledge of biomechanical alterations caused by LSTVs.•Strong linear trend between intensity of 18F-NaF uptake and presence of symptoms.•The grade of 18F-NaF uptake is a possible biological marker for symptomatic LSTV.</description><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLxDAQhYMouK7-AU89emmdJN22AS-y7Kqw4B4qeAtJOoUsbbMm7cL-e1PWs6fhwXszbz5CHilkFGjxfMiMV03GgEEGPAPGr8iC8mKVMia-r8kCAEQqWAG35C6Ewyxzli_InlbbNLjGTn3SdpPztsFEuwGT_aZO13VihySc--PoejVak3RTr11Q8VqXjF4NwY7WDVGc0I-ovbonN63qAj78zSX52m7q9Xu6-3z7WL_uUkPLCmItSpVGxnPNWlQIFativUJoo5tWr4TAthBGoNHRWaoSGq5R6KqlXBSrnC_J02Xv0bufCcMoexsMdp0a0E1BMi6oKHMqIFrZxWq8C8FjK4_e9sqfJQU545MHOeOTMz4JXEZ8MfRyCWF84mTRy2AsDgYb69GMsnH2v_gv-5Z45A</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Usmani, S.</creator><creator>Ahmed, N.</creator><creator>Marafi, F.</creator><creator>al kandari, F.</creator><creator>Gnanasegaran, G.</creator><creator>Van den Wyngaert, T.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra</title><author>Usmani, S. ; Ahmed, N. ; Marafi, F. ; al kandari, F. ; Gnanasegaran, G. ; Van den Wyngaert, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1780-2211abe234b2feae082892669bcbdfb599ef69c9ecb2117a70d3be9b8f1396543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usmani, S.</creatorcontrib><creatorcontrib>Ahmed, N.</creatorcontrib><creatorcontrib>Marafi, F.</creatorcontrib><creatorcontrib>al kandari, F.</creatorcontrib><creatorcontrib>Gnanasegaran, G.</creatorcontrib><creatorcontrib>Van den Wyngaert, T.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usmani, S.</au><au>Ahmed, N.</au><au>Marafi, F.</au><au>al kandari, F.</au><au>Gnanasegaran, G.</au><au>Van den Wyngaert, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra</atitle><jtitle>Clinical radiology</jtitle><date>2020-08</date><risdate>2020</risdate><volume>75</volume><issue>8</issue><spage>643.e1</spage><epage>643.e10</epage><pages>643.e1-643.e10</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><abstract>To analyse the relationship between 18F-labelled sodium fluoride (NaF) uptake and lumbar back pain in patients with lumbosacral transitional vertebra (LSTV) a congenital malformation of the lumbosacral spine. The study population comprised 55 patients (mean age, 51.42 years; median age 52 years) with LSTV. All patients underwent integrated positron-emission tomography (PET)/computed tomography (CT) by injecting 0.06 mCi/kg of 18F-NaF. A three-point grading system was used to evaluate 18F-NaF uptake (grade 0, no uptake; grade 1, mild uptake; and grade 2, marked increase uptake. In total, 55 cases of LSTV (34 symptomatic and 21 asymptomatic) were included. Asymptomatic patients had no uptake in the majority of cases, i.e., grade 0 (n=18) and grade 1 (n=3), whereas symptomatic patients demonstrated focal increase tracer uptake of grade 2 (n=24), grade 1 (n=4), and grade 0 (n=6). There is a strong linear trend between the intensity of 18F-NaF uptake and presence of symptoms (p&lt;0.0001). The sensitivity and specificity of 18F-NaF uptake at LSTV as a cause of pain were 82% (95% confidence interval [CI]: 65–93%) and 86% (95% CI: 64–97%). The positive and negative predictive values were 90% (95% CI: 74–98%) and 75% (95% CI: 53–90%). 18F-NaF PET/CT can be useful in evaluating back pain and 18F-NaF may be used as an adjunctive biological maker for assessing LSTV as a potential cause of pain. •LSTV is an established cause of low back pain especially in young patients.•18F-NaF PET-CT is a sensitive tool for detecting areas of abnormal bone turnover.•18F-NaF provide molecular knowledge of biomechanical alterations caused by LSTVs.•Strong linear trend between intensity of 18F-NaF uptake and presence of symptoms.•The grade of 18F-NaF uptake is a possible biological marker for symptomatic LSTV.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.crad.2020.03.023</doi></addata></record>
fulltext fulltext
identifier ISSN: 0009-9260
ispartof Clinical radiology, 2020-08, Vol.75 (8), p.643.e1-643.e10
issn 0009-9260
1365-229X
language eng
recordid cdi_proquest_miscellaneous_2391974190
source Elsevier ScienceDirect Journals
title 18F-sodium fluoride bone PET-CT in symptomatic lumbosacral transitional vertebra
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T06%3A24%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=18F-sodium%20fluoride%20bone%20PET-CT%20in%20symptomatic%20lumbosacral%20transitional%20vertebra&rft.jtitle=Clinical%20radiology&rft.au=Usmani,%20S.&rft.date=2020-08&rft.volume=75&rft.issue=8&rft.spage=643.e1&rft.epage=643.e10&rft.pages=643.e1-643.e10&rft.issn=0009-9260&rft.eissn=1365-229X&rft_id=info:doi/10.1016/j.crad.2020.03.023&rft_dat=%3Cproquest_cross%3E2391974190%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2391974190&rft_id=info:pmid/&rft_els_id=S0009926020301240&rfr_iscdi=true