Oral spirochetes: Pathogenic mechanisms in periodontal disease
Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune resp...
Gespeichert in:
Veröffentlicht in: | Microbial pathogenesis 2020-07, Vol.144, p.104193-104193, Article 104193 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 104193 |
---|---|
container_issue | |
container_start_page | 104193 |
container_title | Microbial pathogenesis |
container_volume | 144 |
creator | Yousefi, Leila Leylabadlo, Hamed Ebrahimzadeh Pourlak, Tala Eslami, Hosein Taghizadeh, Sepehr Ganbarov, Khudaverdi Yousefi, Mehdi Tanomand, Asghar Yousefi, Bahman Kafil, Hossein Samadi |
description | Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens. |
doi_str_mv | 10.1016/j.micpath.2020.104193 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2391973310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0882401020304800</els_id><sourcerecordid>2391973310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-f0deb98464b56a314c0bccc42b065b899bbf94241d50bc727216c3bc19c66ce3</originalsourceid><addsrcrecordid>eNqFkEtLw0AQxxdRtFY_gpKjl9TZRx7rQZHiCwr10PuSnUzslubhbir47U1J9eppYOb_YH6MXXGYceDp7WZWO-yKfj0TIPY7xbU8YhMOOo25gPyYTSDPRayAwxk7D2EDAFpJfcrOpJCgMp1M2P3SF9sodM63uKaewl30PoS2H9Q4jGrCddG4UIfINVFH3rVl2_SDo3SBikAX7KQqtoEuD3PKVs9Pq_lrvFi-vM0fFzEqyfu4gpKszlWqbJIWkisEi4hKWEgTm2ttbaWVULxMhkMmMsFTlBa5xjRFklN2M8Z2vv3cUehN7QLSdls01O6CEVJznUnJYZAmoxR9G4KnynTe1YX_NhzMnpzZmAM5sydnRnKD7_pQsbM1lX-uX1SD4GEU0PDnlyNvAjpqkErnCXtTtu6fih8uRoGY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2391973310</pqid></control><display><type>article</type><title>Oral spirochetes: Pathogenic mechanisms in periodontal disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yousefi, Leila ; Leylabadlo, Hamed Ebrahimzadeh ; Pourlak, Tala ; Eslami, Hosein ; Taghizadeh, Sepehr ; Ganbarov, Khudaverdi ; Yousefi, Mehdi ; Tanomand, Asghar ; Yousefi, Bahman ; Kafil, Hossein Samadi</creator><creatorcontrib>Yousefi, Leila ; Leylabadlo, Hamed Ebrahimzadeh ; Pourlak, Tala ; Eslami, Hosein ; Taghizadeh, Sepehr ; Ganbarov, Khudaverdi ; Yousefi, Mehdi ; Tanomand, Asghar ; Yousefi, Bahman ; Kafil, Hossein Samadi</creatorcontrib><description>Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2020.104193</identifier><identifier>PMID: 32304795</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adhesins, Bacterial ; Aggressive Periodontitis ; Bacterial Proteins ; Bacterial Toxins ; Gingiva - microbiology ; Lipopolysaccharides ; Lipoproteins ; Oral infection ; Oral spirochetes ; Periodontitis ; Periodontitis - microbiology ; Spirochaetales - classification ; Spirochaetales - genetics ; Spirochaetales - pathogenicity ; Treponema denticola ; Treponema denticola - genetics ; Treponema denticola - pathogenicity ; Virulence Factors - genetics</subject><ispartof>Microbial pathogenesis, 2020-07, Vol.144, p.104193-104193, Article 104193</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-f0deb98464b56a314c0bccc42b065b899bbf94241d50bc727216c3bc19c66ce3</citedby><cites>FETCH-LOGICAL-c431t-f0deb98464b56a314c0bccc42b065b899bbf94241d50bc727216c3bc19c66ce3</cites><orcidid>0000-0001-6026-8795</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2020.104193$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32304795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousefi, Leila</creatorcontrib><creatorcontrib>Leylabadlo, Hamed Ebrahimzadeh</creatorcontrib><creatorcontrib>Pourlak, Tala</creatorcontrib><creatorcontrib>Eslami, Hosein</creatorcontrib><creatorcontrib>Taghizadeh, Sepehr</creatorcontrib><creatorcontrib>Ganbarov, Khudaverdi</creatorcontrib><creatorcontrib>Yousefi, Mehdi</creatorcontrib><creatorcontrib>Tanomand, Asghar</creatorcontrib><creatorcontrib>Yousefi, Bahman</creatorcontrib><creatorcontrib>Kafil, Hossein Samadi</creatorcontrib><title>Oral spirochetes: Pathogenic mechanisms in periodontal disease</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens.</description><subject>Adhesins, Bacterial</subject><subject>Aggressive Periodontitis</subject><subject>Bacterial Proteins</subject><subject>Bacterial Toxins</subject><subject>Gingiva - microbiology</subject><subject>Lipopolysaccharides</subject><subject>Lipoproteins</subject><subject>Oral infection</subject><subject>Oral spirochetes</subject><subject>Periodontitis</subject><subject>Periodontitis - microbiology</subject><subject>Spirochaetales - classification</subject><subject>Spirochaetales - genetics</subject><subject>Spirochaetales - pathogenicity</subject><subject>Treponema denticola</subject><subject>Treponema denticola - genetics</subject><subject>Treponema denticola - pathogenicity</subject><subject>Virulence Factors - genetics</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AQxxdRtFY_gpKjl9TZRx7rQZHiCwr10PuSnUzslubhbir47U1J9eppYOb_YH6MXXGYceDp7WZWO-yKfj0TIPY7xbU8YhMOOo25gPyYTSDPRayAwxk7D2EDAFpJfcrOpJCgMp1M2P3SF9sodM63uKaewl30PoS2H9Q4jGrCddG4UIfINVFH3rVl2_SDo3SBikAX7KQqtoEuD3PKVs9Pq_lrvFi-vM0fFzEqyfu4gpKszlWqbJIWkisEi4hKWEgTm2ttbaWVULxMhkMmMsFTlBa5xjRFklN2M8Z2vv3cUehN7QLSdls01O6CEVJznUnJYZAmoxR9G4KnynTe1YX_NhzMnpzZmAM5sydnRnKD7_pQsbM1lX-uX1SD4GEU0PDnlyNvAjpqkErnCXtTtu6fih8uRoGY</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Yousefi, Leila</creator><creator>Leylabadlo, Hamed Ebrahimzadeh</creator><creator>Pourlak, Tala</creator><creator>Eslami, Hosein</creator><creator>Taghizadeh, Sepehr</creator><creator>Ganbarov, Khudaverdi</creator><creator>Yousefi, Mehdi</creator><creator>Tanomand, Asghar</creator><creator>Yousefi, Bahman</creator><creator>Kafil, Hossein Samadi</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6026-8795</orcidid></search><sort><creationdate>202007</creationdate><title>Oral spirochetes: Pathogenic mechanisms in periodontal disease</title><author>Yousefi, Leila ; Leylabadlo, Hamed Ebrahimzadeh ; Pourlak, Tala ; Eslami, Hosein ; Taghizadeh, Sepehr ; Ganbarov, Khudaverdi ; Yousefi, Mehdi ; Tanomand, Asghar ; Yousefi, Bahman ; Kafil, Hossein Samadi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-f0deb98464b56a314c0bccc42b065b899bbf94241d50bc727216c3bc19c66ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adhesins, Bacterial</topic><topic>Aggressive Periodontitis</topic><topic>Bacterial Proteins</topic><topic>Bacterial Toxins</topic><topic>Gingiva - microbiology</topic><topic>Lipopolysaccharides</topic><topic>Lipoproteins</topic><topic>Oral infection</topic><topic>Oral spirochetes</topic><topic>Periodontitis</topic><topic>Periodontitis - microbiology</topic><topic>Spirochaetales - classification</topic><topic>Spirochaetales - genetics</topic><topic>Spirochaetales - pathogenicity</topic><topic>Treponema denticola</topic><topic>Treponema denticola - genetics</topic><topic>Treponema denticola - pathogenicity</topic><topic>Virulence Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousefi, Leila</creatorcontrib><creatorcontrib>Leylabadlo, Hamed Ebrahimzadeh</creatorcontrib><creatorcontrib>Pourlak, Tala</creatorcontrib><creatorcontrib>Eslami, Hosein</creatorcontrib><creatorcontrib>Taghizadeh, Sepehr</creatorcontrib><creatorcontrib>Ganbarov, Khudaverdi</creatorcontrib><creatorcontrib>Yousefi, Mehdi</creatorcontrib><creatorcontrib>Tanomand, Asghar</creatorcontrib><creatorcontrib>Yousefi, Bahman</creatorcontrib><creatorcontrib>Kafil, Hossein Samadi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousefi, Leila</au><au>Leylabadlo, Hamed Ebrahimzadeh</au><au>Pourlak, Tala</au><au>Eslami, Hosein</au><au>Taghizadeh, Sepehr</au><au>Ganbarov, Khudaverdi</au><au>Yousefi, Mehdi</au><au>Tanomand, Asghar</au><au>Yousefi, Bahman</au><au>Kafil, Hossein Samadi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral spirochetes: Pathogenic mechanisms in periodontal disease</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2020-07</date><risdate>2020</risdate><volume>144</volume><spage>104193</spage><epage>104193</epage><pages>104193-104193</pages><artnum>104193</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32304795</pmid><doi>10.1016/j.micpath.2020.104193</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6026-8795</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0882-4010 |
ispartof | Microbial pathogenesis, 2020-07, Vol.144, p.104193-104193, Article 104193 |
issn | 0882-4010 1096-1208 |
language | eng |
recordid | cdi_proquest_miscellaneous_2391973310 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Adhesins, Bacterial Aggressive Periodontitis Bacterial Proteins Bacterial Toxins Gingiva - microbiology Lipopolysaccharides Lipoproteins Oral infection Oral spirochetes Periodontitis Periodontitis - microbiology Spirochaetales - classification Spirochaetales - genetics Spirochaetales - pathogenicity Treponema denticola Treponema denticola - genetics Treponema denticola - pathogenicity Virulence Factors - genetics |
title | Oral spirochetes: Pathogenic mechanisms in periodontal disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T01%3A40%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oral%20spirochetes:%20Pathogenic%20mechanisms%20in%20periodontal%20disease&rft.jtitle=Microbial%20pathogenesis&rft.au=Yousefi,%20Leila&rft.date=2020-07&rft.volume=144&rft.spage=104193&rft.epage=104193&rft.pages=104193-104193&rft.artnum=104193&rft.issn=0882-4010&rft.eissn=1096-1208&rft_id=info:doi/10.1016/j.micpath.2020.104193&rft_dat=%3Cproquest_cross%3E2391973310%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2391973310&rft_id=info:pmid/32304795&rft_els_id=S0882401020304800&rfr_iscdi=true |