A high-resolution measurement of nucleotide sugars by using ion-pair reverse chromatography and tandem columns

N-Linked glycosylation is a cellular process transferring sugars from glycosyl donors to proteins or lipids. Biopharmaceutical products widely produced by culturing mammalian cells such as Chinese hamster ovary (CHO) cells are typically glycosylated during biosynthesis. For some biologics, the N-lin...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2020-06, Vol.412 (15), p.3683-3693
Hauptverfasser:	Sha, Sha, Handelman, Garry, Agarabi, Cyrus, Yoon, Seongkyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Analytical Chemistry Animals Biochemistry Biological products Biopharmaceuticals Biosynthesis Cells Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science CHO Cells Chromatography Chromatography, Reverse-Phase - methods Cricetulus Dextrose Flow rates Flow velocity Food Science Galactose Glucose Glycan Glycosylation High resolution Ion pairs Isomerism Isomers Laboratory Medicine Lipids Mammalian cells Measurement Monitoring/Environmental Analysis Nucleoside Diphosphate Sugars - analysis Nucleoside Diphosphate Sugars - isolation & purification Nucleotides Proteins Quality management Research Paper Separation Sugar
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