Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction

Abstract Background Aberrant activation of epidermal growth factor receptor (EGFR) signaling pathway is associated with the pathogenesis of pulmonary hypertension (PH). However, the effect of icotinib, a first generation of EGFR tyrosine kinase inhibitor (EGFR-TKI), on PH remains to be elucidated. M...

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Veröffentlicht in:	American journal of hypertension 2020-08, Vol.33 (8), p.775-783
Hauptverfasser:	Peng, Li-Yao, Yu, Min, Yang, Ming-Xia, Liu, Ping, Zhou, Hong, Huang, Wen, Kong, Hui, Xie, Wei-Ping
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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