Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease
Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic...
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| creator | Sabogal-Guáqueta, Angélica María Arias-Londoño, Julián David Gutierrez-Vargas, Johanna Sepulveda-Falla, D. Glatzel, M. Villegas-Lanau, Andrés Cardona-Gómez, Gloria Patricia |
| description | Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic signatures could provide powerful tools to manage these diseases. Therefore, the main goal of this study was to compare the postmortem frontal cortex gray matter, white matter and cerebrospinal fluid (CSF) between a cognitively healthy group and CADASIL and SAD groups. We evaluated 352 individual lipids, belonging to 13 lipid classes/subclasses, using mass spectrometry, and the lipid profiles were subjected to multivariate analysis to discriminate between the dementia groups (CADASIL and SAD) and healthy controls. The main lipid molecular species showing greater discrimination by partial least squares-discriminant analysis (PLS-DA) and a higher significance multivariate correlation (sMC) index were as follows: phosphatidylserine (PS) PS(44:7) and lysophosphatidylethanolamine (LPE) LPE(18:2) in gray matter (GM); phosphatidylethanolamine (PE) PE(32:2) and phosphatidylcholine PC PC(44:6) in white matter (WM), and ether PE (ePE) ePE(38:2) and ether PC (ePC) ePC(34:3) in CSF. Common phospholipid molecular species were obtained in both dementias, such as PS(44:7) and lyso PC (LPC) LPC(22:5) in GM, PE(32:2) in WM and phosphatidic acid (PA) PA(38:5) and PC(42:7) in CFS. Our exploratory study suggests that phospholipids (PLs) involved in neurotransmission alteration, connectivity impairment and inflammation response in GM, WM and CSF are a transversal phenomenon affecting dementias such as CADASIL and SAD independent of the etiopathogenesis, thus providing a possible common prodromal phospholipidic biomarker of dementia.
•Dendrite retraction and microgliosis are common in CADASIL and SAD.•PS (44:7) disbalance in the frontal cerebral cortex from dementia groups•PE (32:2) shows convergent deficiency in the white matter of the CADASIL and SAD.•Common changes in phospholipid profiles in CSF of dementia groups |
| doi_str_mv | 10.1016/j.bbadis.2020.165797 |
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•Dendrite retraction and microgliosis are common in CADASIL and SAD.•PS (44:7) disbalance in the frontal cerebral cortex from dementia groups•PE (32:2) shows convergent deficiency in the white matter of the CADASIL and SAD.•Common changes in phospholipid profiles in CSF of dementia groups</description><identifier>ISSN: 0925-4439</identifier><identifier>EISSN: 1879-260X</identifier><identifier>DOI: 10.1016/j.bbadis.2020.165797</identifier><identifier>PMID: 32302650</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Autopsy ; Biomarkers ; Biomarkers - analysis ; CADASIL - diagnosis ; CADASIL - metabolism ; CADASIL - pathology ; Case-Control Studies ; Cerebrospinal fluid ; Dementia ; Discriminant Analysis ; Female ; Frontal Lobe - metabolism ; Frontal Lobe - pathology ; Gray matter ; Gray Matter - metabolism ; Gray Matter - pathology ; Humans ; Least-Squares Analysis ; Male ; Middle Aged ; Multivariate Analysis ; Parenchymal Tissue - metabolism ; Parenchymal Tissue - pathology ; Phospholipids ; Phospholipids - chemistry ; Phospholipids - classification ; Phospholipids - isolation & purification ; Phospholipids - metabolism ; White matter ; White Matter - metabolism ; White Matter - pathology</subject><ispartof>Biochimica et biophysica acta. Molecular basis of disease, 2020-08, Vol.1866 (8), p.165797-165797, Article 165797</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-ea4fdd6ca65e2c43e9eff0a6587f1d017d9dec57bbb66ee532a316ca9d28a66b3</citedby><cites>FETCH-LOGICAL-c408t-ea4fdd6ca65e2c43e9eff0a6587f1d017d9dec57bbb66ee532a316ca9d28a66b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbadis.2020.165797$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32302650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabogal-Guáqueta, Angélica María</creatorcontrib><creatorcontrib>Arias-Londoño, Julián David</creatorcontrib><creatorcontrib>Gutierrez-Vargas, Johanna</creatorcontrib><creatorcontrib>Sepulveda-Falla, D.</creatorcontrib><creatorcontrib>Glatzel, M.</creatorcontrib><creatorcontrib>Villegas-Lanau, Andrés</creatorcontrib><creatorcontrib>Cardona-Gómez, Gloria Patricia</creatorcontrib><title>Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease</title><title>Biochimica et biophysica acta. Molecular basis of disease</title><addtitle>Biochim Biophys Acta Mol Basis Dis</addtitle><description>Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic signatures could provide powerful tools to manage these diseases. Therefore, the main goal of this study was to compare the postmortem frontal cortex gray matter, white matter and cerebrospinal fluid (CSF) between a cognitively healthy group and CADASIL and SAD groups. We evaluated 352 individual lipids, belonging to 13 lipid classes/subclasses, using mass spectrometry, and the lipid profiles were subjected to multivariate analysis to discriminate between the dementia groups (CADASIL and SAD) and healthy controls. The main lipid molecular species showing greater discrimination by partial least squares-discriminant analysis (PLS-DA) and a higher significance multivariate correlation (sMC) index were as follows: phosphatidylserine (PS) PS(44:7) and lysophosphatidylethanolamine (LPE) LPE(18:2) in gray matter (GM); phosphatidylethanolamine (PE) PE(32:2) and phosphatidylcholine PC PC(44:6) in white matter (WM), and ether PE (ePE) ePE(38:2) and ether PC (ePC) ePC(34:3) in CSF. Common phospholipid molecular species were obtained in both dementias, such as PS(44:7) and lyso PC (LPC) LPC(22:5) in GM, PE(32:2) in WM and phosphatidic acid (PA) PA(38:5) and PC(42:7) in CFS. Our exploratory study suggests that phospholipids (PLs) involved in neurotransmission alteration, connectivity impairment and inflammation response in GM, WM and CSF are a transversal phenomenon affecting dementias such as CADASIL and SAD independent of the etiopathogenesis, thus providing a possible common prodromal phospholipidic biomarker of dementia.
•Dendrite retraction and microgliosis are common in CADASIL and SAD.•PS (44:7) disbalance in the frontal cerebral cortex from dementia groups•PE (32:2) shows convergent deficiency in the white matter of the CADASIL and SAD.•Common changes in phospholipid profiles in CSF of dementia groups</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Autopsy</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>CADASIL - diagnosis</subject><subject>CADASIL - metabolism</subject><subject>CADASIL - pathology</subject><subject>Case-Control Studies</subject><subject>Cerebrospinal fluid</subject><subject>Dementia</subject><subject>Discriminant Analysis</subject><subject>Female</subject><subject>Frontal Lobe - metabolism</subject><subject>Frontal Lobe - pathology</subject><subject>Gray matter</subject><subject>Gray Matter - metabolism</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Least-Squares Analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Parenchymal Tissue - metabolism</subject><subject>Parenchymal Tissue - pathology</subject><subject>Phospholipids</subject><subject>Phospholipids - chemistry</subject><subject>Phospholipids - classification</subject><subject>Phospholipids - isolation & purification</subject><subject>Phospholipids - metabolism</subject><subject>White matter</subject><subject>White Matter - metabolism</subject><subject>White Matter - pathology</subject><issn>0925-4439</issn><issn>1879-260X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdtq3DAQhkVoSTaHNwhBd-2NtzrY8qoXhWWbtoGFBNJC7oQOY6zFtlzJ27J5gD53tDjtZXWj0zfzz8yP0DUlS0qo-LBbGqOdT0tGWH4SVS3rE7Sgq1oWTJCnN2hBJKuKsuTyDJ2ntCN5iZqcojPOOGGiIgv0ZxP6Pgw4JzK604MF7Ac8tYBN1Pk06giDbQ-9xqHBDnoYJq_TR_zQhjS2ofOjd3iMofEdYD3o7pB8wgam3wAD3qw_rx_vtvnD4TSGmAu2eN09t-B7iO_SURd0gkv0ttFdgqvX_QL9-HL7ffOt2N5_vdust4UtyWoqQJeNc8JqUQGzJQcJTUPybVU31BFaO-nAVrUxRgiAijPNacalYysthOEX6P2cN1f8cw9pUr1PFrrcOYR9UoxLKmvGK5rRckZtDClFaNQYfa_jQVGijg6onZodUEcH1OxADrt5VdibHty_oL8jz8CnGYDc5y8PUSXr84zB-Qh2Ui74_yu8AB8ym6s</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Sabogal-Guáqueta, Angélica María</creator><creator>Arias-Londoño, Julián David</creator><creator>Gutierrez-Vargas, Johanna</creator><creator>Sepulveda-Falla, D.</creator><creator>Glatzel, M.</creator><creator>Villegas-Lanau, Andrés</creator><creator>Cardona-Gómez, Gloria Patricia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease</title><author>Sabogal-Guáqueta, Angélica María ; Arias-Londoño, Julián David ; Gutierrez-Vargas, Johanna ; Sepulveda-Falla, D. ; Glatzel, M. ; Villegas-Lanau, Andrés ; Cardona-Gómez, Gloria Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-ea4fdd6ca65e2c43e9eff0a6587f1d017d9dec57bbb66ee532a316ca9d28a66b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Autopsy</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>CADASIL - diagnosis</topic><topic>CADASIL - metabolism</topic><topic>CADASIL - pathology</topic><topic>Case-Control Studies</topic><topic>Cerebrospinal fluid</topic><topic>Dementia</topic><topic>Discriminant Analysis</topic><topic>Female</topic><topic>Frontal Lobe - metabolism</topic><topic>Frontal Lobe - pathology</topic><topic>Gray matter</topic><topic>Gray Matter - metabolism</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Least-Squares Analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Parenchymal Tissue - metabolism</topic><topic>Parenchymal Tissue - pathology</topic><topic>Phospholipids</topic><topic>Phospholipids - chemistry</topic><topic>Phospholipids - classification</topic><topic>Phospholipids - isolation & purification</topic><topic>Phospholipids - metabolism</topic><topic>White matter</topic><topic>White Matter - metabolism</topic><topic>White Matter - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabogal-Guáqueta, Angélica María</creatorcontrib><creatorcontrib>Arias-Londoño, Julián David</creatorcontrib><creatorcontrib>Gutierrez-Vargas, Johanna</creatorcontrib><creatorcontrib>Sepulveda-Falla, D.</creatorcontrib><creatorcontrib>Glatzel, M.</creatorcontrib><creatorcontrib>Villegas-Lanau, Andrés</creatorcontrib><creatorcontrib>Cardona-Gómez, Gloria Patricia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta. Molecular basis of disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabogal-Guáqueta, Angélica María</au><au>Arias-Londoño, Julián David</au><au>Gutierrez-Vargas, Johanna</au><au>Sepulveda-Falla, D.</au><au>Glatzel, M.</au><au>Villegas-Lanau, Andrés</au><au>Cardona-Gómez, Gloria Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease</atitle><jtitle>Biochimica et biophysica acta. Molecular basis of disease</jtitle><addtitle>Biochim Biophys Acta Mol Basis Dis</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>1866</volume><issue>8</issue><spage>165797</spage><epage>165797</epage><pages>165797-165797</pages><artnum>165797</artnum><issn>0925-4439</issn><eissn>1879-260X</eissn><abstract>Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic signatures could provide powerful tools to manage these diseases. Therefore, the main goal of this study was to compare the postmortem frontal cortex gray matter, white matter and cerebrospinal fluid (CSF) between a cognitively healthy group and CADASIL and SAD groups. We evaluated 352 individual lipids, belonging to 13 lipid classes/subclasses, using mass spectrometry, and the lipid profiles were subjected to multivariate analysis to discriminate between the dementia groups (CADASIL and SAD) and healthy controls. The main lipid molecular species showing greater discrimination by partial least squares-discriminant analysis (PLS-DA) and a higher significance multivariate correlation (sMC) index were as follows: phosphatidylserine (PS) PS(44:7) and lysophosphatidylethanolamine (LPE) LPE(18:2) in gray matter (GM); phosphatidylethanolamine (PE) PE(32:2) and phosphatidylcholine PC PC(44:6) in white matter (WM), and ether PE (ePE) ePE(38:2) and ether PC (ePC) ePC(34:3) in CSF. Common phospholipid molecular species were obtained in both dementias, such as PS(44:7) and lyso PC (LPC) LPC(22:5) in GM, PE(32:2) in WM and phosphatidic acid (PA) PA(38:5) and PC(42:7) in CFS. Our exploratory study suggests that phospholipids (PLs) involved in neurotransmission alteration, connectivity impairment and inflammation response in GM, WM and CSF are a transversal phenomenon affecting dementias such as CADASIL and SAD independent of the etiopathogenesis, thus providing a possible common prodromal phospholipidic biomarker of dementia.
•Dendrite retraction and microgliosis are common in CADASIL and SAD.•PS (44:7) disbalance in the frontal cerebral cortex from dementia groups•PE (32:2) shows convergent deficiency in the white matter of the CADASIL and SAD.•Common changes in phospholipid profiles in CSF of dementia groups</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32302650</pmid><doi>10.1016/j.bbadis.2020.165797</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - metabolism Alzheimer Disease - pathology Autopsy Biomarkers Biomarkers - analysis CADASIL - diagnosis CADASIL - metabolism CADASIL - pathology Case-Control Studies Cerebrospinal fluid Dementia Discriminant Analysis Female Frontal Lobe - metabolism Frontal Lobe - pathology Gray matter Gray Matter - metabolism Gray Matter - pathology Humans Least-Squares Analysis Male Middle Aged Multivariate Analysis Parenchymal Tissue - metabolism Parenchymal Tissue - pathology Phospholipids Phospholipids - chemistry Phospholipids - classification Phospholipids - isolation & purification Phospholipids - metabolism White matter White Matter - metabolism White Matter - pathology |
| title | Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease |
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