Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity

Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of sensitivity to anticancer agents has not been well explored in colorectal cancer. We established a platform for pharmacogenomic profiling of p...

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Veröffentlicht in:	Clinical cancer research 2020-08, Vol.26 (15), p.4107-4119
Hauptverfasser:	Bruun, Jarle, Kryeziu, Kushtrim, Eide, Peter W, Moosavi, Seyed H, Eilertsen, Ina A, Langerud, Jonas, Røsok, Bård, Totland, Max Z, Brunsell, Tuva H, Pellinen, Teijo, Saarela, Jani, Bergsland, Christian H, Palmer, Hector G, Brudvik, Kristoffer W, Guren, Tormod, Dienstmann, Rodrigo, Guren, Marianne G, Nesbakken, Arild, Bjørnbeth, Bjørn Atle, Sveen, Anita, Lothe, Ragnhild A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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