Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

Human toll-like receptor 8 (TLR8) activation induces a potent T helper-1 (Th1) cell response critical for defense against intracellular pathogens, including protozoa. The receptor harbors two distinct binding sites, uridine and di- and/or trinucleotides, but the RNases upstream of TLR8 remain poorly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-04, Vol.52 (4), p.591-605.e6
Hauptverfasser:	Ostendorf, Thomas, Zillinger, Thomas, Andryka, Katarzyna, Schlee-Guimaraes, Thais Marina, Schmitz, Saskia, Marx, Samira, Bayrak, Kübra, Linke, Rebecca, Salgert, Sarah, Wegner, Julia, Grasser, Tatjana, Bauersachs, Sonja, Soltesz, Leon, Hübner, Marc P., Nastaly, Maximilian, Coch, Christoph, Kettwig, Matthias, Roehl, Ingo, Henneke, Marco, Hoerauf, Achim, Barchet, Winfried, Gärtner, Jutta, Schlee, Martin, Hartmann, Gunther, Bartok, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation antibacterial immunity Antiviral drugs antiviral immunity Bacteria bacterial RNA Binding sites Erythrocytes immune sensing of nucleic acids Immune system immunity to protozoa innate immunity Ligands Lymphocytes T Pathogens Proteins Protozoa Receptors Ribonuclease T2 Ribonucleic acid RNA RNA metabolism RNase2 RNaseA RnaseT2 Supplements TLR8 Toll-like receptors Uridine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!