Predictors of response to medications for asthma in pediatric patients: A systematic review of the literature
Objectives There has been no systematic review of studies aimed to predict differential responses to medication regimens for asthma controller therapies in pediatric patients. The aim of the present study was to summarize those identifying biomarkers for the different asthma controller therapies. Me...
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| Veröffentlicht in: | Pediatric pulmonology 2020-06, Vol.55 (6), p.1320-1331 |
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| container_title | Pediatric pulmonology |
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| creator | Rodriguez‐Martinez, Carlos E. Sossa‐Briceño, Monica P. Castro‐Rodriguez, Jose A. |
| description | Objectives
There has been no systematic review of studies aimed to predict differential responses to medication regimens for asthma controller therapies in pediatric patients. The aim of the present study was to summarize those identifying biomarkers for the different asthma controller therapies.
Methods
Studies published by June 2019 that report phenotypic or genotypic characteristics or biomarkers that could potentially serve as response predictors to asthma controller therapies in pediatric patients were included. The quality of studies was assessed using the Cochrane Risk of Bias tool and the Newcastle‐Ottawa Scale tool.
Results
Of 385 trials identified, 30 studies were included. Children with asthma and a positive family history of asthma, with more severe disease, of the white race, with allergy biomarkers, nonobese, with lower lung function, high bronchial hyperresponsiveness to methacholine, or having variants in the FCER2 and CRHR1 gene respond better to inhaled corticosteroids (ICS). Younger age ( |
| doi_str_mv | 10.1002/ppul.24782 |
| format | Article |
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There has been no systematic review of studies aimed to predict differential responses to medication regimens for asthma controller therapies in pediatric patients. The aim of the present study was to summarize those identifying biomarkers for the different asthma controller therapies.
Methods
Studies published by June 2019 that report phenotypic or genotypic characteristics or biomarkers that could potentially serve as response predictors to asthma controller therapies in pediatric patients were included. The quality of studies was assessed using the Cochrane Risk of Bias tool and the Newcastle‐Ottawa Scale tool.
Results
Of 385 trials identified, 30 studies were included. Children with asthma and a positive family history of asthma, with more severe disease, of the white race, with allergy biomarkers, nonobese, with lower lung function, high bronchial hyperresponsiveness to methacholine, or having variants in the FCER2 and CRHR1 gene respond better to inhaled corticosteroids (ICS). Younger age (<10 years), short disease duration (<4 years), high cotinine and urinary leukotriene E4 (LTE4) levels, and 5/5 ALOX5 were associated with a better response to leukotriene receptor antagonist (LTRA). For patients that remain symptomatic, white Hispanics were more likely to respond to LTRA, blacks to ICS, white non‐Hispanics to LTRA or LABA, and children without a history of eczema, regardless of race or ethnicity to LABA set‐up therapy. In severe persistent asthma, those with atopy and body mass index greater than or equal 25 were more likely to benefit from omalizumab.
Conclusion
Several phenotypic characteristics, biomarkers, or pharmacogenomics markers could be useful for predicting the best drug for asthma treatment.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.24782</identifier><identifier>PMID: 32297708</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Asthma ; Biomarkers ; Monoclonal antibodies ; pediatric asthma ; Pediatrics ; personalized medicine ; pharmacogenomics ; pulmonary response ; Systematic review</subject><ispartof>Pediatric pulmonology, 2020-06, Vol.55 (6), p.1320-1331</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-2645271d84733ac59b0fa1b6b64cdb85ef06c752d47ef77e5b25d1e2664967053</citedby><cites>FETCH-LOGICAL-c3572-2645271d84733ac59b0fa1b6b64cdb85ef06c752d47ef77e5b25d1e2664967053</cites><orcidid>0000-0002-0708-4281 ; 0000-0003-2560-6693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.24782$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.24782$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32297708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez‐Martinez, Carlos E.</creatorcontrib><creatorcontrib>Sossa‐Briceño, Monica P.</creatorcontrib><creatorcontrib>Castro‐Rodriguez, Jose A.</creatorcontrib><title>Predictors of response to medications for asthma in pediatric patients: A systematic review of the literature</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Objectives
There has been no systematic review of studies aimed to predict differential responses to medication regimens for asthma controller therapies in pediatric patients. The aim of the present study was to summarize those identifying biomarkers for the different asthma controller therapies.
Methods
Studies published by June 2019 that report phenotypic or genotypic characteristics or biomarkers that could potentially serve as response predictors to asthma controller therapies in pediatric patients were included. The quality of studies was assessed using the Cochrane Risk of Bias tool and the Newcastle‐Ottawa Scale tool.
Results
Of 385 trials identified, 30 studies were included. Children with asthma and a positive family history of asthma, with more severe disease, of the white race, with allergy biomarkers, nonobese, with lower lung function, high bronchial hyperresponsiveness to methacholine, or having variants in the FCER2 and CRHR1 gene respond better to inhaled corticosteroids (ICS). Younger age (<10 years), short disease duration (<4 years), high cotinine and urinary leukotriene E4 (LTE4) levels, and 5/5 ALOX5 were associated with a better response to leukotriene receptor antagonist (LTRA). For patients that remain symptomatic, white Hispanics were more likely to respond to LTRA, blacks to ICS, white non‐Hispanics to LTRA or LABA, and children without a history of eczema, regardless of race or ethnicity to LABA set‐up therapy. In severe persistent asthma, those with atopy and body mass index greater than or equal 25 were more likely to benefit from omalizumab.
Conclusion
Several phenotypic characteristics, biomarkers, or pharmacogenomics markers could be useful for predicting the best drug for asthma treatment.</description><subject>Asthma</subject><subject>Biomarkers</subject><subject>Monoclonal antibodies</subject><subject>pediatric asthma</subject><subject>Pediatrics</subject><subject>personalized medicine</subject><subject>pharmacogenomics</subject><subject>pulmonary response</subject><subject>Systematic review</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1P5SAUhokZo3fUjT9gQjIbM0kVKB9ldsaoY3IT70LXDaWnEdOWDlDN_fdSr87CxawIvE8e4LwInVJyTglhF9M09-eMq4rtoRUlWheEa_kNrSolRCErWR6i7zE-E5IzTQ_QYcmYVopUKzRsArTOJh8i9h0OECc_RsDJ42EJTHJ5jzsfsInpaTDYjXjKiUnBWTzlHMYUf-NLHLcxwZAPbNa8OHhdhOkJcO8SBJPmAMdovzN9hJOP9Qg93lw_XP0p1ve3d1eX68KWQrGCSS6Yom3FVVkaK3RDOkMb2Uhu26YS0BFplWAtV9ApBaJhoqXApMz_VkSUR-hs552C_ztDTPXgooW-NyP4Odas1CTfIXWV0Z9f0Gc_hzG_bqG0qijnPFO_dpQNPsYAXT0FN5iwrSmplxLqpYT6vYQM__hQzk0e4j_0c-oZoDvg1fWw_Y-q3mwe1zvpG18nkn0</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Rodriguez‐Martinez, Carlos E.</creator><creator>Sossa‐Briceño, Monica P.</creator><creator>Castro‐Rodriguez, Jose A.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0708-4281</orcidid><orcidid>https://orcid.org/0000-0003-2560-6693</orcidid></search><sort><creationdate>202006</creationdate><title>Predictors of response to medications for asthma in pediatric patients: A systematic review of the literature</title><author>Rodriguez‐Martinez, Carlos E. ; Sossa‐Briceño, Monica P. ; Castro‐Rodriguez, Jose A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3572-2645271d84733ac59b0fa1b6b64cdb85ef06c752d47ef77e5b25d1e2664967053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Asthma</topic><topic>Biomarkers</topic><topic>Monoclonal antibodies</topic><topic>pediatric asthma</topic><topic>Pediatrics</topic><topic>personalized medicine</topic><topic>pharmacogenomics</topic><topic>pulmonary response</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez‐Martinez, Carlos E.</creatorcontrib><creatorcontrib>Sossa‐Briceño, Monica P.</creatorcontrib><creatorcontrib>Castro‐Rodriguez, Jose A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez‐Martinez, Carlos E.</au><au>Sossa‐Briceño, Monica P.</au><au>Castro‐Rodriguez, Jose A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of response to medications for asthma in pediatric patients: A systematic review of the literature</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>55</volume><issue>6</issue><spage>1320</spage><epage>1331</epage><pages>1320-1331</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Objectives
There has been no systematic review of studies aimed to predict differential responses to medication regimens for asthma controller therapies in pediatric patients. The aim of the present study was to summarize those identifying biomarkers for the different asthma controller therapies.
Methods
Studies published by June 2019 that report phenotypic or genotypic characteristics or biomarkers that could potentially serve as response predictors to asthma controller therapies in pediatric patients were included. The quality of studies was assessed using the Cochrane Risk of Bias tool and the Newcastle‐Ottawa Scale tool.
Results
Of 385 trials identified, 30 studies were included. Children with asthma and a positive family history of asthma, with more severe disease, of the white race, with allergy biomarkers, nonobese, with lower lung function, high bronchial hyperresponsiveness to methacholine, or having variants in the FCER2 and CRHR1 gene respond better to inhaled corticosteroids (ICS). Younger age (<10 years), short disease duration (<4 years), high cotinine and urinary leukotriene E4 (LTE4) levels, and 5/5 ALOX5 were associated with a better response to leukotriene receptor antagonist (LTRA). For patients that remain symptomatic, white Hispanics were more likely to respond to LTRA, blacks to ICS, white non‐Hispanics to LTRA or LABA, and children without a history of eczema, regardless of race or ethnicity to LABA set‐up therapy. In severe persistent asthma, those with atopy and body mass index greater than or equal 25 were more likely to benefit from omalizumab.
Conclusion
Several phenotypic characteristics, biomarkers, or pharmacogenomics markers could be useful for predicting the best drug for asthma treatment.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32297708</pmid><doi>10.1002/ppul.24782</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-0708-4281</orcidid><orcidid>https://orcid.org/0000-0003-2560-6693</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Asthma Biomarkers Monoclonal antibodies pediatric asthma Pediatrics personalized medicine pharmacogenomics pulmonary response Systematic review |
| title | Predictors of response to medications for asthma in pediatric patients: A systematic review of the literature |
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