Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study
Background If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD. Objectives To investigate whether the Timed Up and Go test is associated with PD. Methods We included 1,196,614 partic...
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| Veröffentlicht in: | Movement disorders 2020-07, Vol.35 (7), p.1263-1267 |
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| container_title | Movement disorders |
| container_volume | 35 |
| creator | Yoo, Jung Eun Jang, Wooyoung Shin, Dong Wook Jeong, Su‐Min Jung, Hee‐Won Youn, Jinyoung Han, Kyungdo Kim, Bongseong |
| description | Background
If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.
Objectives
To investigate whether the Timed Up and Go test is associated with PD.
Methods
We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into |
| doi_str_mv | 10.1002/mds.28055 |
| format | Article |
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If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.
Objectives
To investigate whether the Timed Up and Go test is associated with PD.
Methods
We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data.
Results
During the median follow‐up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20–1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63–2.92).
Conclusion
An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development. © 2020 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.28055</identifier><identifier>PMID: 32293759</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Basal ganglia ; Central nervous system diseases ; Cohort analysis ; Confidence intervals ; Humans ; Incidence ; mild parkinsonian signs ; Movement disorders ; Neurodegenerative diseases ; Parkinson Disease - diagnosis ; Parkinson Disease - epidemiology ; Parkinson's disease ; Postural Balance ; prodromal Parkinson's disease ; Retrospective Studies ; Time and Motion Studies ; Timed Up and Go test</subject><ispartof>Movement disorders, 2020-07, Vol.35 (7), p.1263-1267</ispartof><rights>2020 International Parkinson and Movement Disorder Society</rights><rights>2020 International Parkinson and Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-2c46557ceaf4200078be17ea8f7768889dca83a576df628e359539cc4a4715203</citedby><cites>FETCH-LOGICAL-c3535-2c46557ceaf4200078be17ea8f7768889dca83a576df628e359539cc4a4715203</cites><orcidid>0000-0003-3350-5032</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.28055$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.28055$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32293759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Jung Eun</creatorcontrib><creatorcontrib>Jang, Wooyoung</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Jeong, Su‐Min</creatorcontrib><creatorcontrib>Jung, Hee‐Won</creatorcontrib><creatorcontrib>Youn, Jinyoung</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Kim, Bongseong</creatorcontrib><title>Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>Background
If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.
Objectives
To investigate whether the Timed Up and Go test is associated with PD.
Methods
We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data.
Results
During the median follow‐up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20–1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63–2.92).
Conclusion
An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development. © 2020 International Parkinson and Movement Disorder Society</description><subject>Basal ganglia</subject><subject>Central nervous system diseases</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Humans</subject><subject>Incidence</subject><subject>mild parkinsonian signs</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Postural Balance</subject><subject>prodromal Parkinson's disease</subject><subject>Retrospective Studies</subject><subject>Time and Motion Studies</subject><subject>Timed Up and Go test</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1O5DAQgC0EggWu4AWQJQq4IuCfTOzQrRYOkIA7HUttGWciDLvxEieg7XiEe8Z7EgwLFEhUM8WnTzMfIVuc7XPGxMG0ivtCM4AlMuAgeaYFqGUyYFpDJrmGNbIe4x1jnAMvVsmaFKKUCsoBqcZ-ihW9nlHbVPQk0DHG7m3vbpH-9fGehpr-se29b2JodiM98hFtxEM6pJe286H5__zvyVcJxq4NcYau849IR-E2tB296vpqvklWajuJ-ON9bpDrX8fj0Wl2_vvkbDQ8z5wECZlweQGgHNo6F4wxpW-QK7S6VqrQWpeVs1paUEVVF0KjhBJk6Vxuc8VBMLlB9hbeWRse-vSImfrocDKxDYY-GiFLxgulcpXQnS_oXejbJl1nRC4ACiUKSNTPBeXSZ7HF2sxaP7Xt3HBmXtOblN68pU_s9ruxv0lJP8mP1gk4WABPfoLz703m4uhqoXwBTlqLtA</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Yoo, Jung Eun</creator><creator>Jang, Wooyoung</creator><creator>Shin, Dong Wook</creator><creator>Jeong, Su‐Min</creator><creator>Jung, Hee‐Won</creator><creator>Youn, Jinyoung</creator><creator>Han, Kyungdo</creator><creator>Kim, Bongseong</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3350-5032</orcidid></search><sort><creationdate>202007</creationdate><title>Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study</title><author>Yoo, Jung Eun ; Jang, Wooyoung ; Shin, Dong Wook ; Jeong, Su‐Min ; Jung, Hee‐Won ; Youn, Jinyoung ; Han, Kyungdo ; Kim, Bongseong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-2c46557ceaf4200078be17ea8f7768889dca83a576df628e359539cc4a4715203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Basal ganglia</topic><topic>Central nervous system diseases</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Humans</topic><topic>Incidence</topic><topic>mild parkinsonian signs</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Postural Balance</topic><topic>prodromal Parkinson's disease</topic><topic>Retrospective Studies</topic><topic>Time and Motion Studies</topic><topic>Timed Up and Go test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Jung Eun</creatorcontrib><creatorcontrib>Jang, Wooyoung</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Jeong, Su‐Min</creatorcontrib><creatorcontrib>Jung, Hee‐Won</creatorcontrib><creatorcontrib>Youn, Jinyoung</creatorcontrib><creatorcontrib>Han, Kyungdo</creatorcontrib><creatorcontrib>Kim, Bongseong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Jung Eun</au><au>Jang, Wooyoung</au><au>Shin, Dong Wook</au><au>Jeong, Su‐Min</au><au>Jung, Hee‐Won</au><au>Youn, Jinyoung</au><au>Han, Kyungdo</au><au>Kim, Bongseong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2020-07</date><risdate>2020</risdate><volume>35</volume><issue>7</issue><spage>1263</spage><epage>1267</epage><pages>1263-1267</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Background
If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.
Objectives
To investigate whether the Timed Up and Go test is associated with PD.
Methods
We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data.
Results
During the median follow‐up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20–1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63–2.92).
Conclusion
An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development. © 2020 International Parkinson and Movement Disorder Society</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32293759</pmid><doi>10.1002/mds.28055</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3350-5032</orcidid></addata></record> |
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| ispartof | Movement disorders, 2020-07, Vol.35 (7), p.1263-1267 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Basal ganglia Central nervous system diseases Cohort analysis Confidence intervals Humans Incidence mild parkinsonian signs Movement disorders Neurodegenerative diseases Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson's disease Postural Balance prodromal Parkinson's disease Retrospective Studies Time and Motion Studies Timed Up and Go test |
| title | Timed Up and Go Test and the Risk of Parkinson's Disease: A Nation‐wide Retrospective Cohort Study |
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