A domino annulation approach to 3,4-diacylpyrrolo[1,2-]pyrazines: decoration of pyrazine units

A new one-pot, sequential three-component access to 3,4-diacylpyrrolo[1,2- a ]pyrazine was achieved from the reaction of an α-haloketone, azide, and N -substituted pyrrole-2-carboxaldehyde under mild reaction conditions, through which a polysubstitution pattern on the pyrazine moiety of the scaffold...

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Veröffentlicht in:	Organic & biomolecular chemistry 2020-05, Vol.18 (17), p.3324-3333
Hauptverfasser:	Dagar, Anuradha, Seo, Yohan, Namkung, Wan, Kim, Ikyon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenosquamous Anticancer properties Antitumor activity Breast cancer Cancer Chemical reactions Crystallography Indoles NMR Nuclear magnetic resonance Pyrazine Pyrazines Squamous cell carcinoma Synthesis
Online-Zugang:	Volltext
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