CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced by tumors, neutrophils, and granulocytic myeloid-derived suppressor cells (MDSCs) from cancer patients extrude their neutrophil ext...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-05, Vol.52 (5), p.856-871.e8
Hauptverfasser:	Teijeira, Álvaro, Garasa, Saray, Gato, María, Alfaro, Carlos, Migueliz, Itziar, Cirella, Assunta, de Andrea, Carlos, Ochoa, Maria Carmen, Otano, Itziar, Etxeberria, Iñaki, Andueza, Maria Pilar, Nieto, Celia P., Resano, Leyre, Azpilikueta, Arantza, Allegretti, Marcello, de Pizzol, Maria, Ponz-Sarvisé, Mariano, Rouzaut, Ana, Sanmamed, Miguel F., Schalper, Kurt, Carleton, Michael, Mellado, Mario, Rodriguez-Ruiz, María E., Berraondo, Pedro, Perez-Gracia, Jose L., Melero, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animals Arginine Arginine deiminase Blocking Cancer CD8 antigen Cell Line, Tumor Chemokines Chemotactic factors CXCR2 protein Cytotoxicity Cytotoxicity, Immunologic - immunology Deoxyribonucleic acid DNA Extracellular Traps - metabolism HT29 Cells Humans immune checkpoint blockade Immune checkpoint inhibitors Immune system Inhibitors Intravital Microscopy - methods Killer Cells, Natural - immunology Leukocytes (neutrophilic) Ligands Lymphocytes Lymphocytes T Metastases Metastasis Mice Natural killer cells Neoplasms, Experimental - immunology Neoplasms, Experimental - metabolism Neoplasms, Experimental - therapy neutrophil extracellular traps Neutrophils Receptors Receptors, Chemokine - agonists Receptors, Chemokine - immunology Receptors, Chemokine - metabolism Receptors, Interleukin-8A - agonists Receptors, Interleukin-8A - immunology Receptors, Interleukin-8A - metabolism Receptors, Interleukin-8B - agonists Receptors, Interleukin-8B - immunology Receptors, Interleukin-8B - metabolism Suppressor cells T-Lymphocytes, Cytotoxic - immunology Thrombosis Toxicity Tumor cells tumor-associated neutrophils Tumors
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