Pharmacological targeting of immune checkpoint A2aR improves function of anti-CD19 CAR T cells in vitro

•Adenosine-enriched tumor microenvironment limits the efficacy of CAR T cell therapy.•CAR-mediated activation augments A2aR expression in the huCAR19 T cells in vitro.•Pharmacological targeting of A2aR boosts proliferation and cytokine production of huCAR19 T cells in vitro. In spite of impressive r...

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Veröffentlicht in:	Immunology letters 2020-07, Vol.223, p.44-52
Hauptverfasser:	Fallah-Mehrjardi, Keyvan, Mirzaei, Hamid Reza, Masoumi, Elham, Jafarzadeh, Leila, Rostamian, Hosein, Khakpoor-Koosheh, Mohammad, Alishah, Khadijeh, Noorbakhsh, Farshid, Hadjati, Jamshid
Format:	Artikel
Sprache:	eng
Schlagworte:	A2aR Adenosine Chimeric antigen receptor T cells Tumor microenvironment
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