Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress

Although iron disequilibrium has been observed frequently in high-fat diet (HFD) related insulin resistance (IR) the exact mechanism still obscure. Herein, we explore the potential mechanism, focusing on hepatic ferritinophagy flow. Male C57/6J mice were administered with HFD or low-fat diet (LFD) f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Food and chemical toxicology 2020-06, Vol.140, p.111329-111329, Article 111329
Hauptverfasser:	Jiang, Chunjie, Zhang, Shanshan, Li, Dan, Chen, Li, Zhao, Ying, Mei, Guibin, Liu, Jingjing, Tang, Yuhan, Gao, Chao, Yao, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Diet, High-Fat Endoplasmic Reticulum Stress Ferritinophagy flux Ferritins - metabolism Hep G2 Cells Hepatic insulin resistance High-fat diet Humans Insulin Resistance Liver - metabolism Male Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - metabolism Nuclear receptor coactivator 4
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!