Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies
Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. S...
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Veröffentlicht in: | International journal of cancer 2020-10, Vol.147 (8), p.2121-2130 |
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creator | Jiang, Yu‐Ting Gong, Ting‐Ting Zhang, Jia‐Yu Li, Xiu‐Qin Gao, Song Zhao, Yu‐Hong Wu, Qi‐Jun |
description | Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC.
What's new?
To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. Further studies are needed to disentangle the effects of specific causes of infertility in different histological subtypes of ovarian cancer. |
doi_str_mv | 10.1002/ijc.33012 |
format | Article |
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What's new?
To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. Further studies are needed to disentangle the effects of specific causes of infertility in different histological subtypes of ovarian cancer.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.33012</identifier><identifier>PMID: 32285933</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer ; Case-Control Studies ; Cohort analysis ; cohort studies ; Epidemiology ; Female ; Follow-Up Studies ; Humans ; Infertility ; Infertility - complications ; Infertility - pathology ; Invasiveness ; Medical research ; Meta-analysis ; Ovarian cancer ; Ovarian Neoplasms - etiology ; Ovarian Neoplasms - pathology ; Ovary - pathology ; Prospective Studies ; risk ; Risk assessment ; Risk Factors ; Sensitivity analysis</subject><ispartof>International journal of cancer, 2020-10, Vol.147 (8), p.2121-2130</ispartof><rights>2020 UICC</rights><rights>2020 UICC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-e323ee4c1774eba0efbcfe5b8c27938f3655b72c4da0a94e20f10e42ef299d2a3</citedby><cites>FETCH-LOGICAL-c3882-e323ee4c1774eba0efbcfe5b8c27938f3655b72c4da0a94e20f10e42ef299d2a3</cites><orcidid>0000-0001-9421-5114</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.33012$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.33012$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32285933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Yu‐Ting</creatorcontrib><creatorcontrib>Gong, Ting‐Ting</creatorcontrib><creatorcontrib>Zhang, Jia‐Yu</creatorcontrib><creatorcontrib>Li, Xiu‐Qin</creatorcontrib><creatorcontrib>Gao, Song</creatorcontrib><creatorcontrib>Zhao, Yu‐Hong</creatorcontrib><creatorcontrib>Wu, Qi‐Jun</creatorcontrib><title>Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC.
What's new?
To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. Further studies are needed to disentangle the effects of specific causes of infertility in different histological subtypes of ovarian cancer.</description><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cohort analysis</subject><subject>cohort studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infertility</subject><subject>Infertility - complications</subject><subject>Infertility - pathology</subject><subject>Invasiveness</subject><subject>Medical research</subject><subject>Meta-analysis</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - etiology</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovary - pathology</subject><subject>Prospective Studies</subject><subject>risk</subject><subject>Risk assessment</subject><subject>Risk Factors</subject><subject>Sensitivity analysis</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9LwzAYBvAgipvTg19AAl70UJc_7dp4kzF1MhBEzyFN32Bml86knezbG-30IHgKL_nx8L4PQqeUXFFC2Ngu9RXnhLI9NKRE5AlhNNtHw_hHkpzyyQAdhbAkhNKMpIdowBkrMsH5ED3NnQHf2tq2W6xchZuN8lY5rJXT4LG34e0azza2gjhj45sVdtYBXvsmrEG3dgNYN6-Nb3Fou8pCOEYHRtUBTnbvCL3czp6n98ni8W4-vVkkmhcFS4AzDpBqmucplIqAKbWBrCw0ywUvDJ9kWZkznVaKKJECI4YSSBkYJkTFFB-hiz43rvLeQWjlygYNda0cNF2QjBdiUoh4cqTnf-iy6byL20mW8ohSwvKoLnul423Bg5Frb1fKbyUl8qtoGYuW30VHe7ZL7MoVVL_yp9kIxj34sDVs_0-S84dpH_kJqjaHFQ</recordid><startdate>20201015</startdate><enddate>20201015</enddate><creator>Jiang, Yu‐Ting</creator><creator>Gong, Ting‐Ting</creator><creator>Zhang, Jia‐Yu</creator><creator>Li, Xiu‐Qin</creator><creator>Gao, Song</creator><creator>Zhao, Yu‐Hong</creator><creator>Wu, Qi‐Jun</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9421-5114</orcidid></search><sort><creationdate>20201015</creationdate><title>Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies</title><author>Jiang, Yu‐Ting ; Gong, Ting‐Ting ; Zhang, Jia‐Yu ; Li, Xiu‐Qin ; Gao, Song ; Zhao, Yu‐Hong ; Wu, Qi‐Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-e323ee4c1774eba0efbcfe5b8c27938f3655b72c4da0a94e20f10e42ef299d2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Cohort analysis</topic><topic>cohort studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infertility</topic><topic>Infertility - complications</topic><topic>Infertility - pathology</topic><topic>Invasiveness</topic><topic>Medical research</topic><topic>Meta-analysis</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - etiology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovary - pathology</topic><topic>Prospective Studies</topic><topic>risk</topic><topic>Risk assessment</topic><topic>Risk Factors</topic><topic>Sensitivity analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Yu‐Ting</creatorcontrib><creatorcontrib>Gong, Ting‐Ting</creatorcontrib><creatorcontrib>Zhang, Jia‐Yu</creatorcontrib><creatorcontrib>Li, Xiu‐Qin</creatorcontrib><creatorcontrib>Gao, Song</creatorcontrib><creatorcontrib>Zhao, Yu‐Hong</creatorcontrib><creatorcontrib>Wu, Qi‐Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Yu‐Ting</au><au>Gong, Ting‐Ting</au><au>Zhang, Jia‐Yu</au><au>Li, Xiu‐Qin</au><au>Gao, Song</au><au>Zhao, Yu‐Hong</au><au>Wu, Qi‐Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2020-10-15</date><risdate>2020</risdate><volume>147</volume><issue>8</issue><spage>2121</spage><epage>2130</epage><pages>2121-2130</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC.
What's new?
To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. Further studies are needed to disentangle the effects of specific causes of infertility in different histological subtypes of ovarian cancer.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32285933</pmid><doi>10.1002/ijc.33012</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9421-5114</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cancer Case-Control Studies Cohort analysis cohort studies Epidemiology Female Follow-Up Studies Humans Infertility Infertility - complications Infertility - pathology Invasiveness Medical research Meta-analysis Ovarian cancer Ovarian Neoplasms - etiology Ovarian Neoplasms - pathology Ovary - pathology Prospective Studies risk Risk assessment Risk Factors Sensitivity analysis |
title | Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies |
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