Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies

Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. S...

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Veröffentlicht in:International journal of cancer 2020-10, Vol.147 (8), p.2121-2130
Hauptverfasser: Jiang, Yu‐Ting, Gong, Ting‐Ting, Zhang, Jia‐Yu, Li, Xiu‐Qin, Gao, Song, Zhao, Yu‐Hong, Wu, Qi‐Jun
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container_end_page 2130
container_issue 8
container_start_page 2121
container_title International journal of cancer
container_volume 147
creator Jiang, Yu‐Ting
Gong, Ting‐Ting
Zhang, Jia‐Yu
Li, Xiu‐Qin
Gao, Song
Zhao, Yu‐Hong
Wu, Qi‐Jun
description Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC. What's new? To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. Further studies are needed to disentangle the effects of specific causes of infertility in different histological subtypes of ovarian cancer.
doi_str_mv 10.1002/ijc.33012
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We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC. What's new? To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. 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Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC. What's new? To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. 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Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC. What's new? To date, the epidemiological studies exploring the relationship between infertility and the risk of ovarian cancer have been inconclusive. For the first time, here the authors conducted a meta‐analysis of nine prospective cohort studies comprising 10 383 ovarian cancer cases and 6 278 830 participants. The findings suggest that infertility in women is associated with a 51% increased risk of ovarian cancer. 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subjects Cancer
Case-Control Studies
Cohort analysis
cohort studies
Epidemiology
Female
Follow-Up Studies
Humans
Infertility
Infertility - complications
Infertility - pathology
Invasiveness
Medical research
Meta-analysis
Ovarian cancer
Ovarian Neoplasms - etiology
Ovarian Neoplasms - pathology
Ovary - pathology
Prospective Studies
risk
Risk assessment
Risk Factors
Sensitivity analysis
title Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies
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