High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke

High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke

BACKGROUND AND PURPOSE—Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. METHODS—We used data from PROSCIS-B (Prospective...

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Veröffentlicht in:Stroke (1970) 2020-05, Vol.51 (5), p.1604-1607
Hauptverfasser: Broersen, Leonie H.A., Siegerink, Bob, Sperber, Pia S., von Rennenberg, Regina, Piper, Sophie K., Nolte, Christian H., Heuschmann, Peter U., Endres, Matthias, Scheitz, Jan F., Liman, Thomas G.
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container_end_page 1607
container_issue 5
container_start_page 1604
container_title Stroke (1970)
container_volume 51
creator Broersen, Leonie H.A.
Siegerink, Bob
Sperber, Pia S.
von Rennenberg, Regina
Piper, Sophie K.
Nolte, Christian H.
Heuschmann, Peter U.
Endres, Matthias
Scheitz, Jan F.
Liman, Thomas G.
description BACKGROUND AND PURPOSE—Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. METHODS—We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination
doi_str_mv 10.1161/STROKEAHA.119.028410
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METHODS—We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination &lt;27; Telephone Interview for Cognitive Status–modified &lt;32). Association of hs-cTnT with cognitive function over time was estimated using a linear mixed model. RESULTS—We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time. CONCLUSIONS—In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up. REGISTRATION—URLhttps://www.clinicaltrials.gov; Unique identifierNCT01363856.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.119.028410</identifier><identifier>PMID: 32279621</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><ispartof>Stroke (1970), 2020-05, Vol.51 (5), p.1604-1607</ispartof><rights>American Heart Association, Inc.</rights><rights>2020 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4980-4b27c72b4bb1d69fe90eee199ee8e671c54af052752c0992fa2fe264e99e43113</citedby><cites>FETCH-LOGICAL-c4980-4b27c72b4bb1d69fe90eee199ee8e671c54af052752c0992fa2fe264e99e43113</cites><orcidid>0000-0002-8454-9142 ; 0000-0001-5835-4627 ; 0000-0001-5577-1775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32279621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broersen, Leonie H.A.</creatorcontrib><creatorcontrib>Siegerink, Bob</creatorcontrib><creatorcontrib>Sperber, Pia S.</creatorcontrib><creatorcontrib>von Rennenberg, Regina</creatorcontrib><creatorcontrib>Piper, Sophie K.</creatorcontrib><creatorcontrib>Nolte, Christian H.</creatorcontrib><creatorcontrib>Heuschmann, Peter U.</creatorcontrib><creatorcontrib>Endres, Matthias</creatorcontrib><creatorcontrib>Scheitz, Jan F.</creatorcontrib><creatorcontrib>Liman, Thomas G.</creatorcontrib><title>High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Our study aim was to assess whether high-sensitivity cardiac troponin T (hs-cTnT), a specific biomarker for myocardial injury, is associated with cognitive function in patients after mild-to-moderate first-ever ischemic stroke. METHODS—We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination &lt;27; Telephone Interview for Cognitive Status–modified &lt;32). Association of hs-cTnT with cognitive function over time was estimated using a linear mixed model. RESULTS—We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time. CONCLUSIONS—In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up. 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METHODS—We used data from PROSCIS-B (Prospective Cohort With Incident Stroke Berlin). Cognitive function was assessed by Mini-Mental-State-Examination at baseline, and Telephone Interview for Cognitive Status–modified after 1 to 3 years of follow-up. Patients were categorized according to hs-cTnT quartiles. We performed generalized linear regression to calculate risk ratios of cognitive impairment (Mini-Mental-State-Examination &lt;27; Telephone Interview for Cognitive Status–modified &lt;32). Association of hs-cTnT with cognitive function over time was estimated using a linear mixed model. RESULTS—We included 555 patients (mean age, 67 years, 62% male, median National Institutes of Health Stroke Scale 2 [interquartile range, 1–5], hs-cTnT above upper reference limit 40%, baseline cognitive impairment 28%). Baseline Mini-Mental-State-Examination score and rate of cognitive impairment were lower in patients in the highest versus lowest hs-cTnT quartile (median Mini-Mental-State-Examination 27 versus 29, and 15.3% versus 43.0%, adjusted risk ratio, 1.76 [95% CI, 1.07–2.90], respectively). If anything, cognition seemed to improve in all groups, yet Telephone Interview for Cognitive Status–modified scores were consistently lower in patients within the highest versus lowest hs-cTnT quartile (adjusted β, −1.33 [95% CI, −2.65 to −0.02]), without difference in the rate of change over time. CONCLUSIONS—In patients with mild-to-moderate first-ever ischemic stroke without dementia, higher hs-cTnT was associated with higher prevalence of cognitive impairment at baseline and lower Telephone Interview for Cognitive Status–modified during 3-year follow-up. REGISTRATION—URLhttps://www.clinicaltrials.gov; Unique identifierNCT01363856.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>32279621</pmid><doi>10.1161/STROKEAHA.119.028410</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8454-9142</orcidid><orcidid>https://orcid.org/0000-0001-5835-4627</orcidid><orcidid>https://orcid.org/0000-0001-5577-1775</orcidid><oa>free_for_read</oa></addata></record>
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title High-Sensitivity Cardiac Troponin T and Cognitive Function in Patients With Ischemic Stroke
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