Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life

•KA-SZ in P25 rat increased seizure severity, injury, and activated microglia at P39.•Short course (2-day) dexamethasone after KA-SZ decreased acute microglia activation.•Post-SZ dexamethasone decreased severity of seizures provoked at P39.•Post-SE dexamethasone decreased second SZ-induced microglia...

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Veröffentlicht in:	Neuroscience letters 2020-05, Vol.728, p.134953-134953, Article 134953
Hauptverfasser:	Fox, Patrick, Mithal, Divakar S., Somogyi, Jason R., Vien, Albert C., Sanchez, Russell M., Koh, Sookyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory dexamethasone Dexamethasone - pharmacology Disease Models, Animal epilepsy Epilepsy - chemically induced Epilepsy - drug therapy Hippocampus - drug effects Inflammation - immunology Kainic Acid - pharmacology Macrophage Activation - drug effects Male microglia Microglia - drug effects minocycline Neurons - drug effects Rats, Long-Evans Seizures - chemically induced Seizures - drug therapy two-hit model
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