MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion
Previous researches have indicated that miR-4317 was aberrantly expressed in several tumors. However, the potential role of miR-4317 in breast cancer is still unclear. The aim of this study was to investigate the potential role of miR-4317 in breast cancer. The relative expression levels of miR-4317...
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| Veröffentlicht in: | Clinical and experimental medicine 2020-08, Vol.20 (3), p.417-425 |
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| creator | Sheng, Yuwei Hu, Rong Zhang, Yi Luo, Wenjie |
| description | Previous researches have indicated that miR-4317 was aberrantly expressed in several tumors. However, the potential role of miR-4317 in breast cancer is still unclear. The aim of this study was to investigate the potential role of miR-4317 in breast cancer. The relative expression levels of miR-4317 were detected in breast cancer tissues and cell lines using qRT-PCR analysis. The Kaplan–Meier survival curve and multivariate Cox regression analyses were used to investigate the prognostic significance of miR-4317 in breast cancer. CCK-8 and Transwell assays were performed to evaluate the effects of miR-4317 on cell proliferation, migration, and invasion. The results showed that miR-4317 expression was decreased in breast cancer tissues and cell lines. Downregulation of miR-4317 was significantly associated with lymph node metastasis, TNM stage, and poor prognosis. Overexpression of miR-4317 inhibited proliferation, migration, and invasion of breast cancer cells, while downregulation of miR-4317 exhibited the opposite effects. MYD88 may be a direct target of miR-4317. The results suggest miR-4317 may play a tumor suppressor role in breast cancer and inhibit proliferation, migration, and invasion of breast cancer cells by targeting MYD88. The findings provide novel evidence of miR-4317 as a potential prognostic biomarker and therapeutic target for breast cancer. |
| doi_str_mv | 10.1007/s10238-020-00625-4 |
| format | Article |
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However, the potential role of miR-4317 in breast cancer is still unclear. The aim of this study was to investigate the potential role of miR-4317 in breast cancer. The relative expression levels of miR-4317 were detected in breast cancer tissues and cell lines using qRT-PCR analysis. The Kaplan–Meier survival curve and multivariate Cox regression analyses were used to investigate the prognostic significance of miR-4317 in breast cancer. CCK-8 and Transwell assays were performed to evaluate the effects of miR-4317 on cell proliferation, migration, and invasion. The results showed that miR-4317 expression was decreased in breast cancer tissues and cell lines. Downregulation of miR-4317 was significantly associated with lymph node metastasis, TNM stage, and poor prognosis. Overexpression of miR-4317 inhibited proliferation, migration, and invasion of breast cancer cells, while downregulation of miR-4317 exhibited the opposite effects. MYD88 may be a direct target of miR-4317. The results suggest miR-4317 may play a tumor suppressor role in breast cancer and inhibit proliferation, migration, and invasion of breast cancer cells by targeting MYD88. The findings provide novel evidence of miR-4317 as a potential prognostic biomarker and therapeutic target for breast cancer.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-020-00625-4</identifier><identifier>PMID: 32279128</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Breast cancer ; Cell growth ; Cell migration ; Cell proliferation ; Cholecystokinin ; Hematology ; Internal Medicine ; Lymph nodes ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; miRNA ; MyD88 protein ; Oncology ; Original Article ; Prognosis ; Therapeutic applications ; Tumor cell lines ; Tumor suppressor genes ; Tumors</subject><ispartof>Clinical and experimental medicine, 2020-08, Vol.20 (3), p.417-425</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a04adfed21e378ce710ccf74dcd205e5cec0079477bb69c240cc263f48832553</citedby><cites>FETCH-LOGICAL-c375t-a04adfed21e378ce710ccf74dcd205e5cec0079477bb69c240cc263f48832553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10238-020-00625-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10238-020-00625-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32279128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheng, Yuwei</creatorcontrib><creatorcontrib>Hu, Rong</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Luo, Wenjie</creatorcontrib><title>MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><addtitle>Clin Exp Med</addtitle><description>Previous researches have indicated that miR-4317 was aberrantly expressed in several tumors. However, the potential role of miR-4317 in breast cancer is still unclear. The aim of this study was to investigate the potential role of miR-4317 in breast cancer. The relative expression levels of miR-4317 were detected in breast cancer tissues and cell lines using qRT-PCR analysis. The Kaplan–Meier survival curve and multivariate Cox regression analyses were used to investigate the prognostic significance of miR-4317 in breast cancer. CCK-8 and Transwell assays were performed to evaluate the effects of miR-4317 on cell proliferation, migration, and invasion. The results showed that miR-4317 expression was decreased in breast cancer tissues and cell lines. Downregulation of miR-4317 was significantly associated with lymph node metastasis, TNM stage, and poor prognosis. Overexpression of miR-4317 inhibited proliferation, migration, and invasion of breast cancer cells, while downregulation of miR-4317 exhibited the opposite effects. MYD88 may be a direct target of miR-4317. The results suggest miR-4317 may play a tumor suppressor role in breast cancer and inhibit proliferation, migration, and invasion of breast cancer cells by targeting MYD88. The findings provide novel evidence of miR-4317 as a potential prognostic biomarker and therapeutic target for breast cancer.</description><subject>Breast cancer</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cholecystokinin</subject><subject>Hematology</subject><subject>Internal Medicine</subject><subject>Lymph nodes</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>miRNA</subject><subject>MyD88 protein</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Therapeutic applications</subject><subject>Tumor cell lines</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UcFO3DAUtCpQWaA_wAFZ4tJDA_azvXaOK9QWpC1IiLvlOC-L0SZZ7KRS_x6HLK3EoSe_pzczHs0QcsbZJWdMXyXOQJiCASsYW4Iq5Cey4KrkRanAHOxnY0p2RI5TemaMKyPYZ3IkAHTJwSzI8Cv42D_crQopuKa7iHXwQ6LDE-al33R9Con2Da0iujRQ7zqPkbqupqF7ClWYsGPbR-pxu50o29BgdEPou2-0DZv3cWb8dilvp-SwcduEX_bvCXn88f3x-qZY3_-8vV6tCy-0GgrHpKsbrIGj0Maj5sz7Rsva18AUKo8-x1BKratqWXqQ-QxL0UhjBCglTsjXWTa7ehkxDbYNabLpOuzHZHN4JUxJTtCLD9DnfoxdNmdBgpRLJQVkFMyoHFlKERu7i6F18Y_lzE5Cdq7E5krsWyVWZtL5XnqsWqz_Ut47yAAxA1I-dRuM__7-j-wrkSuWpA</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Sheng, Yuwei</creator><creator>Hu, Rong</creator><creator>Zhang, Yi</creator><creator>Luo, Wenjie</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion</title><author>Sheng, Yuwei ; Hu, Rong ; Zhang, Yi ; Luo, Wenjie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a04adfed21e378ce710ccf74dcd205e5cec0079477bb69c240cc263f48832553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Breast cancer</topic><topic>Cell growth</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Cholecystokinin</topic><topic>Hematology</topic><topic>Internal Medicine</topic><topic>Lymph nodes</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>miRNA</topic><topic>MyD88 protein</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Therapeutic applications</topic><topic>Tumor cell lines</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheng, Yuwei</creatorcontrib><creatorcontrib>Hu, Rong</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Luo, Wenjie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheng, Yuwei</au><au>Hu, Rong</au><au>Zhang, Yi</au><au>Luo, Wenjie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion</atitle><jtitle>Clinical and experimental medicine</jtitle><stitle>Clin Exp Med</stitle><addtitle>Clin Exp Med</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>20</volume><issue>3</issue><spage>417</spage><epage>425</epage><pages>417-425</pages><issn>1591-8890</issn><eissn>1591-9528</eissn><abstract>Previous researches have indicated that miR-4317 was aberrantly expressed in several tumors. However, the potential role of miR-4317 in breast cancer is still unclear. The aim of this study was to investigate the potential role of miR-4317 in breast cancer. The relative expression levels of miR-4317 were detected in breast cancer tissues and cell lines using qRT-PCR analysis. The Kaplan–Meier survival curve and multivariate Cox regression analyses were used to investigate the prognostic significance of miR-4317 in breast cancer. CCK-8 and Transwell assays were performed to evaluate the effects of miR-4317 on cell proliferation, migration, and invasion. The results showed that miR-4317 expression was decreased in breast cancer tissues and cell lines. Downregulation of miR-4317 was significantly associated with lymph node metastasis, TNM stage, and poor prognosis. Overexpression of miR-4317 inhibited proliferation, migration, and invasion of breast cancer cells, while downregulation of miR-4317 exhibited the opposite effects. MYD88 may be a direct target of miR-4317. 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| subjects | Breast cancer Cell growth Cell migration Cell proliferation Cholecystokinin Hematology Internal Medicine Lymph nodes Medical prognosis Medicine Medicine & Public Health Metastases miRNA MyD88 protein Oncology Original Article Prognosis Therapeutic applications Tumor cell lines Tumor suppressor genes Tumors |
| title | MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion |
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