The mechanisms of baicalin ameliorate obesity and hyperlipidemia through a network pharmacology approach

Obesity is one of the main causes of human cardiovascular and cerebrovascular diseases. Baicalin, a bioactive flavonoid isolated from the herbal medicine Scutellaria baicalensis Georgi, is reported to ameliorate obesity and hyperlipidemia. However, its mechanism remains unclear. Here, we used networ...

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Veröffentlicht in:	European journal of pharmacology 2020-07, Vol.878, p.173103-173103, Article 173103
Hauptverfasser:	Wang, Zi-Yuan, Jiang, Zheng-Meng, Xiao, Ping-Ting, Jiang, Ying-Qun, Liu, Wen-Jin, Liu, E-Hu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Obesity Agents - pharmacology Baicalin Caspase 3 - genetics Caspase 3 - metabolism Drug Discovery Flavonoids - pharmacology Gene Expression Regulation Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Hep G2 Cells Herbal Medicine Humans Hyperlipidemia Hyperlipidemias - drug therapy Hypolipidemic Agents - pharmacology Models, Molecular Molecular Structure Network pharmacology NF-kappa B p50 Subunit - genetics NF-kappa B p50 Subunit - metabolism Obesity Obesity - drug therapy Plant Extracts - pharmacology Protein Binding Protein Conformation Signal Transduction Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Structure-Activity Relationship Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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