ZEB and Snail expression indicates epithelial-mesenchymal transition in canine melanoma

Melanoma progression is associated with the epithelial-mesenchymal transition (EMT) when tumor cells reduce E-cadherin and increase N-cadherin expression resulting in an escape from the microenvironment via loss of cellular adhesion and gain of motility. Transcription factor proteins Snail and ZEB t...

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Veröffentlicht in:	Research in veterinary science 2020-08, Vol.131, p.7-14
Hauptverfasser:	Veloso, Emerson Soares, Gonçalves, Ivy Nayra Nascimento, Silveira, Tatiany Luiza, Espirito Santo, Juliane Taynar, Figueiredo, Larissa Vieira, Varaschin, Mary Suzan, Cassali, Geovanni Dantas, Del Puerto, Helen Lima, Ferreira, Enio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Binding sites Cadherins Cell adhesion Cell membranes Correlation Cytoplasm Dogs E-cadherin Epithelium-mesenchymal transition Gene regulation Labeling Life Sciences & Biomedicine Medical prognosis Melanoma Mesenchyme Morphology N-Cadherin Nuclear transport Nuclei (cytology) Physical characteristics Polymers Proteins Science & Technology Skin cancer Snail protein Transcription factors Translocation Tumor cells Tumors Veterinary medicine Veterinary Sciences ZEB
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