Cobalt-Catalyzed Regioselective Carboamidation of Alkynes with Imides Enabled by Cleavage of C–N and C–C Bonds
Through the oxidative addition of cobalt into the N–C(O) bond of phthalimide and the subsequent decarbonylation, we describe an efficient cobalt-catalyzed intermolecular decarbonylative carboamidation of alkynes. High regioselectivities have been achieved for unsymmetrical alkynes (including aryl–a...
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| Veröffentlicht in: | Organic letters 2020-05, Vol.22 (9), p.3386-3391 |
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| container_title | Organic letters |
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| creator | Min, Xiang-Ting Ji, Ding-Wei Zheng, Hao Chen, Bing-Zhi Hu, Yan-Cheng Wan, Boshun Chen, Qing-An |
| description | Through the oxidative addition of cobalt into the N–C(O) bond of phthalimide and the subsequent decarbonylation, we describe an efficient cobalt-catalyzed intermolecular decarbonylative carboamidation of alkynes. High regioselectivities have been achieved for unsymmetrical alkynes (including aryl–alkyl or aryl–aryl) to deliver polysubstituted isoquinolones. To facilitate step economy, a three-component decarbonylative carboamidation of alkynes with phthalic anhydrides and amines has been demonstrated using the current cobalt catalysis. |
| doi_str_mv | 10.1021/acs.orglett.0c00875 |
| format | Article |
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Lett</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>22</volume><issue>9</issue><spage>3386</spage><epage>3391</epage><pages>3386-3391</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>Through the oxidative addition of cobalt into the N–C(O) bond of phthalimide and the subsequent decarbonylation, we describe an efficient cobalt-catalyzed intermolecular decarbonylative carboamidation of alkynes. High regioselectivities have been achieved for unsymmetrical alkynes (including aryl–alkyl or aryl–aryl) to deliver polysubstituted isoquinolones. 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| title | Cobalt-Catalyzed Regioselective Carboamidation of Alkynes with Imides Enabled by Cleavage of C–N and C–C Bonds |
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