Disparities between Antibody Occupancy, Orientation, and Cytotoxicity in Immunotherapy

We report fusion proteins designed to bind spatially distinct epitopes on the extracellular portion of HER2, a breast cancer biomarker and established therapeutic target, and recruit IgG (either anti‐His6 or serum IgG) to the cell surface. When the proteins were incubated with anti‐His6 antibody and...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2020-09, Vol.21 (17), p.2435-2439
Hauptverfasser:	Ta, Angeline N., Tennyson, Rachel L., Aceveda, Diane C., McNaughton, Brian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biomarkers Breast cancer Cell surface Cytotoxicity Epitopes ErbB-2 protein Fusion protein Immunoglobulin G Immunotherapy Nanobodies Occupancy Proteins Recruitment Toxicity
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