Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation
•AMPAr and LVDCCs are necessary for ORM consolidation and reconsolidation.•CaMKII is necessary for ORM consolidation but not reconsolidation.•There is a link between AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and AMPAr and LVDCCs on ORM consolidation and...
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| Veröffentlicht in: | Neuroscience 2020-05, Vol.435, p.112-123 |
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| creator | Furini, Cristiane R.G. Nachtigall, Eduarda G. Behling, Jonny A.K. Assis Brasil, Eduardo S. Saenger, Bruna F. Narvaes, Rodrigo F. de Carvalho Myskiw, Jociane Izquierdo, Ivan |
| description | •AMPAr and LVDCCs are necessary for ORM consolidation and reconsolidation.•CaMKII is necessary for ORM consolidation but not reconsolidation.•There is a link between AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and CaMKII on ORM consolidation.
Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can be again susceptible, allowing modification, updating and strengthening and to be re-stabilized they need a new process referred to as memory reconsolidation. However, the molecular mechanisms of recognition memory consolidation and reconsolidation are not fully understood. Also, considering that the study of the link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, molecular mechanisms in the hippocampus involved on object recognition memory (ORM) consolidation and reconsolidation. We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the molecular mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation. |
| doi_str_mv | 10.1016/j.neuroscience.2020.03.047 |
| format | Article |
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Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can be again susceptible, allowing modification, updating and strengthening and to be re-stabilized they need a new process referred to as memory reconsolidation. However, the molecular mechanisms of recognition memory consolidation and reconsolidation are not fully understood. Also, considering that the study of the link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, molecular mechanisms in the hippocampus involved on object recognition memory (ORM) consolidation and reconsolidation. We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the molecular mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2020.03.047</identifier><identifier>PMID: 32272151</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>AMPA receptors ; Animals ; BDNF ; CaMKII ; Hippocampus ; L-VDCCs calcium channels ; Male ; Memory ; Memory Consolidation ; ORM consolidation ; ORM reconsolidation ; Rats ; Rats, Wistar ; Recognition, Psychology</subject><ispartof>Neuroscience, 2020-05, Vol.435, p.112-123</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-2556d1016355ea6c6f44ca3730c46239f023cfffc999b79a234acc5db28698a13</citedby><cites>FETCH-LOGICAL-c380t-2556d1016355ea6c6f44ca3730c46239f023cfffc999b79a234acc5db28698a13</cites><orcidid>0000-0001-8827-7968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030645222030213X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32272151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furini, Cristiane R.G.</creatorcontrib><creatorcontrib>Nachtigall, Eduarda G.</creatorcontrib><creatorcontrib>Behling, Jonny A.K.</creatorcontrib><creatorcontrib>Assis Brasil, Eduardo S.</creatorcontrib><creatorcontrib>Saenger, Bruna F.</creatorcontrib><creatorcontrib>Narvaes, Rodrigo F.</creatorcontrib><creatorcontrib>de Carvalho Myskiw, Jociane</creatorcontrib><creatorcontrib>Izquierdo, Ivan</creatorcontrib><title>Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>•AMPAr and LVDCCs are necessary for ORM consolidation and reconsolidation.•CaMKII is necessary for ORM consolidation but not reconsolidation.•There is a link between AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and CaMKII on ORM consolidation.
Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can be again susceptible, allowing modification, updating and strengthening and to be re-stabilized they need a new process referred to as memory reconsolidation. However, the molecular mechanisms of recognition memory consolidation and reconsolidation are not fully understood. Also, considering that the study of the link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, molecular mechanisms in the hippocampus involved on object recognition memory (ORM) consolidation and reconsolidation. We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the molecular mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation.</description><subject>AMPA receptors</subject><subject>Animals</subject><subject>BDNF</subject><subject>CaMKII</subject><subject>Hippocampus</subject><subject>L-VDCCs calcium channels</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Consolidation</subject><subject>ORM consolidation</subject><subject>ORM reconsolidation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recognition, Psychology</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1r2zAUhsXoWNNsf6GYXfXGnqwPf-yupN0aSCiM7Voox8erUltyJTuQfz-lSUsupxvBy3O-HkK-5jTLaV5822YWJ-8CGLSAGaOMZpRnVJQfyCyvSp6WUogLMqOcFqmQjF2SqxC2ND4p-CdyyRkrWS7zGXleuw5h6rRP1ghP2prQh8TY5MEMgwPdD1NIlnbnuh02ibPJ42aLMCa_ENxfa0YTozX2zu-ThbPBdabRr6G2zSt0ln0mH1vdBfxy-ufkz4_734uHdPX4c7m4XaXAKzqmTMqiORzKpURdQNEKAZqXnIIoGK9byji0bQt1XW_KWjMuNIBsNqwq6krnfE5ujn0H714mDKPqTQDsOm3RTUExXlUVE7IsI_r9iEL0GTy2avCm136vcqoOO6itOpetDrIV5SrKjsXXpznTpsfmvfTNbgTujgDGa3cGvTq1aYyPElXjzP_M-Qf2H5kU</recordid><startdate>20200521</startdate><enddate>20200521</enddate><creator>Furini, Cristiane R.G.</creator><creator>Nachtigall, Eduarda G.</creator><creator>Behling, Jonny A.K.</creator><creator>Assis Brasil, Eduardo S.</creator><creator>Saenger, Bruna F.</creator><creator>Narvaes, Rodrigo F.</creator><creator>de Carvalho Myskiw, Jociane</creator><creator>Izquierdo, Ivan</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8827-7968</orcidid></search><sort><creationdate>20200521</creationdate><title>Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation</title><author>Furini, Cristiane R.G. ; Nachtigall, Eduarda G. ; Behling, Jonny A.K. ; Assis Brasil, Eduardo S. ; Saenger, Bruna F. ; Narvaes, Rodrigo F. ; de Carvalho Myskiw, Jociane ; Izquierdo, Ivan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-2556d1016355ea6c6f44ca3730c46239f023cfffc999b79a234acc5db28698a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>AMPA receptors</topic><topic>Animals</topic><topic>BDNF</topic><topic>CaMKII</topic><topic>Hippocampus</topic><topic>L-VDCCs calcium channels</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Consolidation</topic><topic>ORM consolidation</topic><topic>ORM reconsolidation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recognition, Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furini, Cristiane R.G.</creatorcontrib><creatorcontrib>Nachtigall, Eduarda G.</creatorcontrib><creatorcontrib>Behling, Jonny A.K.</creatorcontrib><creatorcontrib>Assis Brasil, Eduardo S.</creatorcontrib><creatorcontrib>Saenger, Bruna F.</creatorcontrib><creatorcontrib>Narvaes, Rodrigo F.</creatorcontrib><creatorcontrib>de Carvalho Myskiw, Jociane</creatorcontrib><creatorcontrib>Izquierdo, Ivan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furini, Cristiane R.G.</au><au>Nachtigall, Eduarda G.</au><au>Behling, Jonny A.K.</au><au>Assis Brasil, Eduardo S.</au><au>Saenger, Bruna F.</au><au>Narvaes, Rodrigo F.</au><au>de Carvalho Myskiw, Jociane</au><au>Izquierdo, Ivan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2020-05-21</date><risdate>2020</risdate><volume>435</volume><spage>112</spage><epage>123</epage><pages>112-123</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>•AMPAr and LVDCCs are necessary for ORM consolidation and reconsolidation.•CaMKII is necessary for ORM consolidation but not reconsolidation.•There is a link between AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and AMPAr and LVDCCs on ORM consolidation and reconsolidation.•There is a link between BDNF and CaMKII on ORM consolidation.
Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can be again susceptible, allowing modification, updating and strengthening and to be re-stabilized they need a new process referred to as memory reconsolidation. However, the molecular mechanisms of recognition memory consolidation and reconsolidation are not fully understood. Also, considering that the study of the link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, molecular mechanisms in the hippocampus involved on object recognition memory (ORM) consolidation and reconsolidation. We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the molecular mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>32272151</pmid><doi>10.1016/j.neuroscience.2020.03.047</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-8827-7968</orcidid></addata></record> |
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| subjects | AMPA receptors Animals BDNF CaMKII Hippocampus L-VDCCs calcium channels Male Memory Memory Consolidation ORM consolidation ORM reconsolidation Rats Rats, Wistar Recognition, Psychology |
| title | Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation |
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