Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (COVID-19) 1 – 4 . Currently, there are no targeted therapeutic agents for the treatment of this dise...

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Veröffentlicht in:	Nature (London) 2020-06, Vol.582 (7811), p.289-293
Hauptverfasser:	Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang, Rao, Zihe, Yang, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 631/326/596 631/326/596/4130 631/535/1266 82/16 82/29 82/58 82/80 82/83 Antiviral activity Antiviral agents Binding sites CAD Chemical compounds Clinical trials Computer aided design Coronaviridae Coronaviruses COVID-19 Crystal structure Drug development Drug screening Drugs Enzymes Health services High-throughput screening Humanities and Social Sciences Hydrogen bonds Infectious diseases Inhibitors Lead compounds Middle East respiratory syndrome multidisciplinary Pharmacology Polypeptides Public health Respiratory diseases Science Science (multidisciplinary) Screening Severe acute respiratory syndrome coronavirus 2 Therapeutic targets Transcription Vaccines Viral diseases
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