mTORC1-Mediated Satellite Cell Differentiation Is Required for Lysine-Induced Skeletal Muscle Growth
Skeletal muscle is the primary source of protein for humans. However, the mechanisms of skeletal muscle growth, such as nutrition control, remain unknown. Moreover, the function of lysine (Lys) in controling skeletal muscle growth has gradually demonstrated that Lys is not only substantial for prote...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2020-04, Vol.68 (17), p.4884-4892 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Jin, Cheng-long Zhang, Zong-ming Song, Zhi-wen Gao, Chun-qi Yan, Hui-chao Wang, Xiu-qi |
| description | Skeletal muscle is the primary source of protein for humans. However, the mechanisms of skeletal muscle growth, such as nutrition control, remain unknown. Moreover, the function of lysine (Lys) in controling skeletal muscle growth has gradually demonstrated that Lys is not only substantial for protein synthesis but also a signaling molecule for satellite cell (SC) activation. In the current work, the number of differentiated SCs in the longissimus thoracis muscle and the fusion index of SCs were both governed by Lys supplementation. Meanwhile, the myogenic regulatory factors and the mammalian target of rapamycin complex 1 (mTORC1) pathway showed the same tendencies of changes as the differentiation of SCs. After Lys was resupplemented with rapamycin, the mTORC1 pathway was inhibited and the differentiation ability of SCs was suppressed. Collectively, the results showed that the mTORC1-pathway-mediated SC differentiation was required for Lys-promoted skeletal muscle growth. |
| doi_str_mv | 10.1021/acs.jafc.0c01275 |
| format | Article |
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However, the mechanisms of skeletal muscle growth, such as nutrition control, remain unknown. Moreover, the function of lysine (Lys) in controling skeletal muscle growth has gradually demonstrated that Lys is not only substantial for protein synthesis but also a signaling molecule for satellite cell (SC) activation. In the current work, the number of differentiated SCs in the longissimus thoracis muscle and the fusion index of SCs were both governed by Lys supplementation. Meanwhile, the myogenic regulatory factors and the mammalian target of rapamycin complex 1 (mTORC1) pathway showed the same tendencies of changes as the differentiation of SCs. After Lys was resupplemented with rapamycin, the mTORC1 pathway was inhibited and the differentiation ability of SCs was suppressed. Collectively, the results showed that the mTORC1-pathway-mediated SC differentiation was required for Lys-promoted skeletal muscle growth.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/acs.jafc.0c01275</identifier><identifier>PMID: 32275833</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Cell Differentiation ; Lysine - metabolism ; Mechanistic Target of Rapamycin Complex 1 - genetics ; Mechanistic Target of Rapamycin Complex 1 - metabolism ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Satellite Cells, Skeletal Muscle - cytology ; Satellite Cells, Skeletal Muscle - metabolism ; Swine</subject><ispartof>Journal of agricultural and food chemistry, 2020-04, Vol.68 (17), p.4884-4892</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a336t-cf76892319253e8ed63be65cf923e2c3b0c318147911458b0d4b22888558cbae3</citedby><cites>FETCH-LOGICAL-a336t-cf76892319253e8ed63be65cf923e2c3b0c318147911458b0d4b22888558cbae3</cites><orcidid>0000-0003-2033-9485</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.jafc.0c01275$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.jafc.0c01275$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32275833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Cheng-long</creatorcontrib><creatorcontrib>Zhang, Zong-ming</creatorcontrib><creatorcontrib>Song, Zhi-wen</creatorcontrib><creatorcontrib>Gao, Chun-qi</creatorcontrib><creatorcontrib>Yan, Hui-chao</creatorcontrib><creatorcontrib>Wang, Xiu-qi</creatorcontrib><title>mTORC1-Mediated Satellite Cell Differentiation Is Required for Lysine-Induced Skeletal Muscle Growth</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Skeletal muscle is the primary source of protein for humans. However, the mechanisms of skeletal muscle growth, such as nutrition control, remain unknown. Moreover, the function of lysine (Lys) in controling skeletal muscle growth has gradually demonstrated that Lys is not only substantial for protein synthesis but also a signaling molecule for satellite cell (SC) activation. In the current work, the number of differentiated SCs in the longissimus thoracis muscle and the fusion index of SCs were both governed by Lys supplementation. Meanwhile, the myogenic regulatory factors and the mammalian target of rapamycin complex 1 (mTORC1) pathway showed the same tendencies of changes as the differentiation of SCs. After Lys was resupplemented with rapamycin, the mTORC1 pathway was inhibited and the differentiation ability of SCs was suppressed. Collectively, the results showed that the mTORC1-pathway-mediated SC differentiation was required for Lys-promoted skeletal muscle growth.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>Lysine - metabolism</subject><subject>Mechanistic Target of Rapamycin Complex 1 - genetics</subject><subject>Mechanistic Target of Rapamycin Complex 1 - metabolism</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Satellite Cells, Skeletal Muscle - cytology</subject><subject>Satellite Cells, Skeletal Muscle - metabolism</subject><subject>Swine</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqWwMyGPDKT4USfOiAKUSq0qlTJHjnMtXPIodiLUf49LCxuLr-R7vk-6B6FrSsaUMHqvtB9vlNFjoglliThBQyoYiQSl8hQNSWAiKWI6QBfebwghUiTkHA04C7DkfIjKer1cZTRaQGlVByV-DW9V2Q5wFiZ-tMaAg6YLW9s2eObxCj576wJqWofnO28biGZN2et9-gMq6FSFF73XFeCpa7-690t0ZlTl4eo4R-jt-WmdvUTz5XSWPcwjxXncRdoksUwZpykTHCSUMS8gFtqEP2CaF0RzKukkSSmdCFmQclIwJqUUQupCAR-h20Pv1rWfPfgur63X4QzVQNv7nPEAM5pyElByQLVrvXdg8q2ztXK7nJJ87zYPbvO92_zoNkRuju19UUP5F_iVGYC7A_ATbXvXhGP_7_sGY1GETg</recordid><startdate>20200429</startdate><enddate>20200429</enddate><creator>Jin, Cheng-long</creator><creator>Zhang, Zong-ming</creator><creator>Song, Zhi-wen</creator><creator>Gao, Chun-qi</creator><creator>Yan, Hui-chao</creator><creator>Wang, Xiu-qi</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2033-9485</orcidid></search><sort><creationdate>20200429</creationdate><title>mTORC1-Mediated Satellite Cell Differentiation Is Required for Lysine-Induced Skeletal Muscle Growth</title><author>Jin, Cheng-long ; Zhang, Zong-ming ; Song, Zhi-wen ; Gao, Chun-qi ; Yan, Hui-chao ; Wang, Xiu-qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a336t-cf76892319253e8ed63be65cf923e2c3b0c318147911458b0d4b22888558cbae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>Lysine - metabolism</topic><topic>Mechanistic Target of Rapamycin Complex 1 - genetics</topic><topic>Mechanistic Target of Rapamycin Complex 1 - metabolism</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Satellite Cells, Skeletal Muscle - cytology</topic><topic>Satellite Cells, Skeletal Muscle - metabolism</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Cheng-long</creatorcontrib><creatorcontrib>Zhang, Zong-ming</creatorcontrib><creatorcontrib>Song, Zhi-wen</creatorcontrib><creatorcontrib>Gao, Chun-qi</creatorcontrib><creatorcontrib>Yan, Hui-chao</creatorcontrib><creatorcontrib>Wang, Xiu-qi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Cheng-long</au><au>Zhang, Zong-ming</au><au>Song, Zhi-wen</au><au>Gao, Chun-qi</au><au>Yan, Hui-chao</au><au>Wang, Xiu-qi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mTORC1-Mediated Satellite Cell Differentiation Is Required for Lysine-Induced Skeletal Muscle Growth</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2020-04-29</date><risdate>2020</risdate><volume>68</volume><issue>17</issue><spage>4884</spage><epage>4892</epage><pages>4884-4892</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><abstract>Skeletal muscle is the primary source of protein for humans. However, the mechanisms of skeletal muscle growth, such as nutrition control, remain unknown. Moreover, the function of lysine (Lys) in controling skeletal muscle growth has gradually demonstrated that Lys is not only substantial for protein synthesis but also a signaling molecule for satellite cell (SC) activation. In the current work, the number of differentiated SCs in the longissimus thoracis muscle and the fusion index of SCs were both governed by Lys supplementation. Meanwhile, the myogenic regulatory factors and the mammalian target of rapamycin complex 1 (mTORC1) pathway showed the same tendencies of changes as the differentiation of SCs. 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| subjects | Animals Cell Differentiation Lysine - metabolism Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Satellite Cells, Skeletal Muscle - cytology Satellite Cells, Skeletal Muscle - metabolism Swine |
| title | mTORC1-Mediated Satellite Cell Differentiation Is Required for Lysine-Induced Skeletal Muscle Growth |
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