Aggressive morphologic variants of mantle cell lymphoma characterized with high genomic instability showing frequent chromothripsis, CDKN2A/B loss, and TP53 mutations: A multi‐institutional study

Aggressive morphologic variants of mantle cell lymphoma (MCL), including blastoid and pleomorphic (B/P‐MCL), are rare and associated with poor clinical outcomes. The genomic landscape of these variants remains incompletely explored. In this multi‐institutional study, we describe recurrent mutations...

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Veröffentlicht in:	Genes chromosomes & cancer 2020-08, Vol.59 (8), p.484-494
Hauptverfasser:	Streich, Lukas, Sukhanova, Madina, Lu, Xinyan, Chen, Yi‐Hua, Venkataraman, Girish, Mathews, Stephanie, Zhang, Shanxiang, Kelemen, Katalin, Segal, Jeremy, Gao, Juehua, Gordon, Leo, Chen, Qing, Behdad, Amir
Format:	Artikel
Sprache:	eng
Schlagworte:	blastoid Chromosome 17 Chromosome rearrangements chromothripsis Copy number Genomic instability Lymphoma Mantle cell lymphoma Mutation Next-generation sequencing Notch1 protein p53 Protein pleomorphic Single-nucleotide polymorphism
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